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Composite ferrite nanoparticles for synergistically enhancing liver specificity as well as preparation method and application thereof

A nanoparticle and ferrite technology, applied in nanotechnology, nanotechnology, nanomagnetism, etc. for materials and surface science, can solve problems such as fibrosis, human body risk, and T2 imaging artifacts

Pending Publication Date: 2020-10-27
XIAN SUPERMAG BIO NANOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] Existing reports have been used in liver contrast agents, including superparamagnetic iron oxide nanoparticle T2 contrast agents targeting liver macrophages, but T2 imaging has inherent low signal and is easily related to hemorrhage, calcification, and metal deposition in biological tissues. Low signal is confused, and T2 imaging itself is prone to artifacts, poor contrast and other problems; while gadolinium targeting liver cells is combined with T1 contrast agent, although the ethoxyphenyl functional group can specifically recognize liver cells and achieve liver specificity Contrast imaging, but gadolinium-based contrast agents are cleared through the kidneys, which can easily cause renal systemic fibrosis or even renal failure in patients, and gadolinium ions are easy to dissociate in the body and stay in the central nervous system for a long time, posing potential risks to the human body; the most important thing is The targeting efficiency of gadolinium-based contrast agents in the liver is less than 50%, which limits high-sensitivity imaging of the liver

Method used

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  • Composite ferrite nanoparticles for synergistically enhancing liver specificity as well as preparation method and application thereof
  • Composite ferrite nanoparticles for synergistically enhancing liver specificity as well as preparation method and application thereof
  • Composite ferrite nanoparticles for synergistically enhancing liver specificity as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A method for preparing composite ferrite nanoparticles that synergistically enhances liver specificity: 20 mg of nano manganese ferrite particles and 80 mg of dopamine-polyethylene glycol (Mw=1000)-ethoxybenzene molecules Disperse in 12ml of tetrahydrofuran solution, stir fully under argon atmosphere to obtain a uniform mixture, wherein the molar ratio of manganese to iron is 0.52; heat the mixture to 50°C and keep it for 5h for reaction, after the reaction is completed, naturally cool the mixture to room temperature; 10mL of ether was added to the mixed solution, stirred, precipitation occurred, and then centrifuged, and the product obtained by centrifuged was dissolved in deionized water to obtain composite ferrite nanoparticles containing manganese ions and ethoxyphenyl groups. The result Analysis showed a molar percentage of ethoxyphenyl to manganese ions of 46%.

Embodiment 2

[0025] A method for preparing composite ferrite nanoparticles that synergistically enhances liver specificity: disperse 20 mg of nano-manganese ferrite particles and 50 mg of 3-(4-ethoxyphenyl) propionic acid in 10 ml of tetrahydrofuran In the solution, stir fully under an argon atmosphere to obtain a homogeneous mixture, wherein the molar ratio of manganese to iron is 0.61; heat the mixture to 60°C for 4 hours, and cool the mixture to room temperature naturally after the reaction; take 10mL of ether and add it to the mixture In the process, precipitation occurs and then centrifuged, and the product obtained by centrifugation is dissolved in deionized water to obtain composite ferrite nanoparticles containing manganese ions and ethoxyphenyl groups. The analysis results show that ethoxyphenyl and manganese The molar percentage of ions is 39%.

Embodiment 3

[0027] A method for preparing composite ferrite nanoparticles that synergistically enhances liver specificity: disperse 20 mg of nano-manganese ferrite particles and 120 mg of dopamine-dextran (Mw=2000)-ethoxybenzene molecules in 12ml In tetrahydrofuran solution, stir fully under argon atmosphere to obtain a homogeneous mixture, in which the molar ratio of manganese to iron is 0.52; heat the mixture to 60°C for 5h, and cool the mixture to room temperature naturally after the reaction; take 10mL of acetone and add it to the mixture solution, precipitated and then centrifuged, and the centrifuged product was dissolved in deionized water to obtain composite ferrite nanoparticles containing manganese ions and ethoxyphenyl groups. The analysis results showed that ethoxyphenyl and The molar percentage of manganese ions is 28%.

[0028] A series of characterizations were carried out on the composite ferrite nanoparticles prepared in Example 1. Specifically, the composite ferrite nano...

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Abstract

The invention discloses composite ferrite nanoparticles for synergistically enhancing liver specificity. The composite ferrite nanoparticles contain manganese ions and ethoxyphenyl groups at the sametime, the mole percentage of the ethoxyphenyl groups and the manganese ions is 25-60%, the molar percentage of the manganese ions and iron ions in the ferrite nanoparticles is 40-80%, the particle size range of the composite ferrite nanoparticles with the manganese ions and the ethoxyphenyl groups on the surfaces is 0.2-5 nm, and the preferential particle size range is 2-4 nm. The invention also discloses a preparation method of the composite ferrite nanoparticles and an application of the composite ferrite nanoparticles in preparation of a T1 developer in magnetic resonance imaging. The composite ferrite nanoparticles provided by the invention enhance the hepatocyte specificity due to the synergistic effect of the manganese ions and the ethoxyphenyl groups, so that high-specificity T1 enhanced imaging of the liver in MRI imaging is realized.

Description

technical field [0001] The invention belongs to the technical field of material science and biomedicine, and specifically refers to a compound ferrite nanoparticle synergistically enhancing liver specificity, a preparation method and application thereof. Background technique [0002] Existing reports have been used in liver contrast agents, including superparamagnetic iron oxide nanoparticle T2 contrast agents targeting liver macrophages, but T2 imaging has inherent low signal and is easily related to hemorrhage, calcification, and metal deposition in biological tissues. Low signal is confused, and T2 imaging itself is prone to artifacts, poor contrast and other problems; while gadolinium targeting liver cells is combined with T1 contrast agent, although the ethoxyphenyl functional group can specifically recognize liver cells and achieve liver specificity Contrast imaging, but gadolinium-based contrast agents are cleared through the kidneys, which can easily cause renal syst...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18B82Y25/00B82Y30/00B82Y40/00
CPCA61K49/1833B82Y25/00B82Y30/00B82Y40/00A61K49/183B82Y5/00
Inventor 樊海明张欢彭明丽刘晓丽
Owner XIAN SUPERMAG BIO NANOTECH CO LTD
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