297 results about "MRI - Magnetic resonance imaging" patented technology

The invention discloses a magnetic resonance imaging (MRI) based brain disease individual prediction method and a magnetic resonance imaging (MRI) based brain disease individual prediction system. The method comprises the following steps: 1: obtaining the MRI of the brain of a patient with mental diseases; 2: carrying out denoising and dimension reduction treatment on the MRI of the brain of the patient; 3: carrying out feature selection by utilizing a ReliefF algorithm; 4: adaptively obtaining a spatial brain area by using a spatial cluster analysis method; 5: removing redundant features by utilizing a correlation-based feature selection algorithm, thus obtaining an optimal feature subset; 6: carrying out multiple linear regression analysis based on the optimal feature subset to recognize potential biomarkers. The method has the beneficial effects that the embodiment of the invention integrates various machine learning methods and can rapidly and conveniently achieve quantitative and individual accurate prediction of the interest features of mental diseases, such as clinical indexes, based on various image data in different mode types, thus being beneficial to understanding the brain structures, function abnormity and potential pathogenesis of the diseases.

This invention provides a system and method for fusing and synthesizing a plurality of medical images defined by a plurality of imaging parameters that allow the visual enhancements of each image data set to be selectively combined with those of other image datasets. In this manner, a user-defined parameter set can be generated in the final response image dataset. This final response image dataset displays visual data represents a form particularly useful to the clinician. In an illustrative embodiment, the system for fusing and synthesizing the plurality of medical images provides an image fusion process/processor that fuses a plurality of magnetic resonance imaging (MRI) datasets. A first image dataset of the MRI datasets is defined by apparent diffusion coefficient (ADC) values. A second image dataset of the MRI datasets is defined by at least one parameter other than the ADC values. The image fusion processor generates a fused response image that visually displays a combination of image features generated by the ADC values combined with image features generated by the at least one parameter other than the ADC values. The fused response image can illustratively include at least one of color-enhanced regions of interest and intensity-enhanced regions of interest.

Methods, apparatuses, systems, and software for extended phase correction in phase sensitive Magnetic Resonance Imaging. A magnetic resonance image or images may be loaded into a memory. Two vector images A and B associated with the loaded image or images may be calculated either explicitly or implicitly so that a vector orientation by one of the two vector images at a pixel is substantially determined by a background or error phase at the pixel, and the vector orientation at the pixel by the other vector image is substantially different from that determined by the background or error phase at the pixel. A sequenced region growing phase correction algorithm may be applied to the vector images A and B to construct a new vector image V so that a vector orientation of V at each pixel is substantially determined by the background or error phase at the pixel. A phase corrected magnetic resonance image or images may be generated using the vector image V, and the phase corrected magnetic resonance image or images may be displayed or archived.

Due to the lack of internal anatomic detail with traditional magnetic resonance imaging, preoperative stereotactic planning for the treatment of tremor usually relies on indirect targeting based on atlas-derived coordinates. To overcome such disadvantages, a method is provided that allows for deep brain stimulation targeting based on brain connectivity. For example, probabilistic tractography-based thalamic segmentation for deep brain stimulator (DBS) targeting is suitable for the treatment of tremor.

The invention belongs to the field of prostate disease medical equipment and particularly relates to a method for improving a prostate tumor MRI (Magnetic Resonance Imaging) image identification rate based on a CAD (Computer-Aided Diagnosis) system. The method comprises the following steps: (1) collecting an MRI image of a prostate patient; (2) extracting MRI prostate tumor ROI region features; (3) carrying out feature-grade fusion on the ROI region features; and (4) identifying the fused features by classification through taking a neural network as a classification device. By virtue of the method, the capabilities of identifying the prostate benign and malignant tumors are at least improved by 10%, and the method has active meanings on the CAD of the MRI prostate tumors.

The invention discloses a novel integrated artificial intervertebral disc prosthesis, belongs to medicinal human implants and is used for treating degenerative lumbar diseases. The structure of the artificial intervertebral disc prosthesis is an integral structure, and consists of an upper endplate, a lower endplate, an elastic core, an elastic fiber bundle net, and a polymer gasket, wherein the upper endplate and the lower endplate are made of metal titanium; the elastic core, the elastic fiber bundle net and the polymer gasket are made of a medical polymer material; the elastic core has a structure which is clamped between the upper endplate and the lower endplate and has the elastically supporting function, and the elastic core is designed into a nucleus pulposus-like structure and has the characteristics of supporting and elastically buffering load; the upper endplate and the lower endplate are made of titanium alloy without influencing the magnetic resonance imaging, can develop under X-rays, are made according to physiologic intervertebral disc endplates in shape, are provided with anchorage points so as to conveniently weave fiber bundles, and are sprayed with hydroxyapatite and provided with keel to be favorable for bone ingrowth and prosthesis stabilization; the elastic fiber bundle net is weaved to be anchored on the endplates and weaved into the net outside the elastic core to play a role in connecting various components into a whole; the included angle between the net and the horizontal plane is an acute angle of 30+/-10 degrees so as to match the included angle between the fiber bundles of the human intervertebral disc and the endplates; and the polymer gasket is coated on the outer layer of the fiber bundle to prevent the soft tissue ingrowth and coat the fragments, so that the biocompatibility is improved. Under the ideal condition, the anterior-ventral median sternotomy can be made.

The invention belongs to the technical field of biomedical polymer material and nanobiomaterial, particularly relates to a magnetic nano-carrier with targeted hydrophobic drug delivery to tumor and a preparation method thereof. The magnetic nano-carrier is formed by encapsulating superparamagnetic nano-particles with amphiphilic segmented copolymer methoxy polye thylene glycol-poly(lactide- glycolide) (MePEG-PLGA) micelles. First, a large amount of MePEG-PLGA with good dispersion is synthesized by the improved solution polymerization process, and then the MePEG-PLGA is used as raw materials to encapsulate Fe3O4 nano-particles by the solvent evaporation process to obtain a magnetic nano drug carrier. The carrier is expected to solve the solubility problem of insoluble drugs, achieves slow release of drugs, and achieves the passive-targeting of the drugs by the EPR effect of tumor; Fe3O4 nano-particles are used in the active-targeting of the drugs to reduce the dosage and the side effect and improve the treatment efficiency; besides, the carrier can be used in the magnetic resonance imaging (MRI) of tumor.

The invention discloses a method for preparing a nanometer system for multi-model diagnosis and treatment integration. The method comprises the following steps: adopting an in-situ growth nanogold modified rare-earth upconversion nanoparticle method to perform ligand exchange modification on oil-soluble upconversion luminescence nanoparticles of citric acid with a core-shell structure to be water-soluble, and performing citric acid ligand modification on the surfaces of the nanoparticles; uniformly growing nanogold particles on the surface through an in-situ crystal growth method so as to obtain in-situ growth nanogold modified upconversion luminescence nanoparticles; and linking polyethylene glycol-adriamycin hydrochloride containing hydrazone bonds and thiol onto the nanogold surface, thereby obtaining the rare-earth upconversion nanometer system. The invention further provides the nanometer system and application thereof. The nanometer system provided by the invention is uniform in size, high in stability and high in biocompatibility, has the effects of chemotherapy and photo-thermal physiotherapy and can be applied to the fields of upconversion fluorescence imaging, magnetic resonance imaging, anti-cancer drug delivery, photo-thermal physiotherapy of cancers and the like.

The invention belongs to the technical field of nanometer materials, and particularly relates to a zinc oxide-gadolinium-drug composite nanoparticle, and a preparation method and application thereof. The composite nanoparticle comprises a zinc oxide nanocrystal core, a polymer shell, gadolinium (III) ions modified by coordinate bonds and surface-loaded anti-cancer drug molecules, has high stability, luminescence property and magnetic relaxation rate and can be applied to cell and small animal fluorescence imaging, magnetic resonance imaging, mouse tumor treatment and the like. The preparation method includes coating a zinc oxide nanoparticle with a polymer through two copolymerization reactions, coordinating a large quantity of carboxyl groups carried by the polymer with the gadolinium (III) ions to magnetize the nanoparticle, and loading the drug molecules onto the surface of the nanoparticle. A nanoparticle drug loading platform has a good fluorescence-magnetic resonance imaging function, high drug loading rate and high release rate, is low in toxicity and is completely degraded in mouse bodies without residues, thereby having better biosecurity and medication specificity than anti-cancer drugs.

According to one embodiment, a magnetic resonance imaging apparatus includes an acquiring unit and a generating unit. The acquiring unit performs compensation of a control waveform of a radio-frequency wave based on “an output waveform of a radio-frequency wave from an amplifier before the compensation” so that an intended output waveform of a radio-frequency wave for generating a spatially non-selective radio-frequency magnetic field is outputted from the amplifier, and acquires a magnetic resonance signal using the control waveform of a radio-frequency wave after the compensation. The generating unit generates image data based on the magnetic resonance signal.

The invention describes a method that provides a practical means of accurately estimating the electromagnetic fields and therefore the SAR (specific absorption rate) distributions of a subject in magnetic resonance imaging (MRI) scan. The disclosed method consists of several steps. If the coil information is unavailable during the patent imaging, the first step, generally performed before patient (or target) imaging, estimates the geometry of the radiofrequency (RF) coils. The second step estimates the patient-specific tissue volumes by deforming an appropriate reference with known tissue distribution from a database to the said target. Finally, the electromagnetic fields and the SAR distributions are calculated using numerical methods performed on the accurately estimated RF coils and patient-specific tissue volumes. The proposed method can be used for safe, accurate MR imaging at any magnetic field strengths, particular suitable for high-field applications.

The invention discloses a nanometer cluster medicine carrying thermosensitive liposome preparation and a making method and application thereof. The preparation is obtained after impurity removal of nanometer cluster medicine carrying thermosensitive liposome, wherein the nanometer cluster medicine carrying thermosensitive liposome contains a thermosensitive phosphatide component DPPC, a phosphatide component MPPC capable of promoting release, a phosphatide component DSPE-PEG2000 capable of promoting long circulation of the preparation, and a tumor treating medicine; and the liposome is prepared by a film dispersion method, the surface of the liposome is wrapped with a layer of gold nanometer clusters, or the inner part of the liposome is encapsulated with magnetic Fe3O4 nanoparticles. Thepreparation can be used as an antitumor carrier, is connected with an antibody, and is specifically targeted to tumors, through NIR illumination, the medicine is efficiently released at the positionsof the tumors, and through combination with the sensitization effect of thermotherapy and radiotherapy, the treatment effects are improved. The preparation can also be combined with the advantages ofgold and ferrum in the imaging respect of electronic computer tomoscan imaging (CT)/magnetic resonance imaging (MRI) and the like, and can perform medical diagnosis, so that the purpose of achieving multimode pinpoint diagnosis and treatment of the tumor can be realized.

A local radio frequency (RF) transmitting coil (26) of a magnetic resonance imaging system (5) has a plurality of coil elements (100). Each coil element (100) has an adjustable load (62) which is adjusted by a control unit (60) to adjust a transmitted B1field distribution. The load can be adjusted to shim for a uniform B1 field distribution. Non-uniform B1 field distributions can be selected to perform magnetic resonance sequences that use such B1 field distributions, such as parallel imaging. The B1 field distribution can be changed during the magnetic resonance sequence to track a moving region of interest, time division multiplex parallel imaging, and the like.