The invention belongs to the technical field of environmental functional material preparation, and relates to a preparation method and application of a photothermal
double stimulation response hydrogel containing alpha-
cyclodextrin. The method comprises the following steps: firstly preparing alpha-
cyclodextrin ester and acrylamido
azobenzene, adding the alpha-
cyclodextrin ester, the acrylamido
azobenzene,
methylene bisacrylamide and isopropylacrylamide into a
dimethyl sulfoxide solution, and performing ultrasonic shaking to obtain a
mixed solution B; adding 2,2'-azobis(2,4-dimethyl)valeronitrile into a
dimethyl sulfoxide solution to obtain a mixed liquid D; and finally, adding the mixed liquid D into the mixed liquid B, after mixing is completed, performing a reaction in a water bath to obtain the photothermal
double stimulation response hydrogel. According to the method provided by the invention, the cyclodextrin and the photo and temperature structure response units are introduced into the hydrogel prepared by the method, so that the hydrogel can load a large amount of
drug molecules, and when an external temperature and an illumination
wavelength are changed, the hydrogel can have responsive change of adjusting a release speed of the
drug molecules in time; and at the same time, the method is simple and convenient to operate, and the prepared hydrogel is safe and
environmentally friendly and has good stability.