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Acid/base double stimulation responsive nanometer container and preparation method thereof

A stimuli-responsive, nano-container technology, applied in nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the problems of large volume of adamantane group and complex structure of viologen, and achieve small size, The effect of convenient preparation and simple structure

Inactive Publication Date: 2017-01-18
NANJING UNIV OF SCI & TECH
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Problems solved by technology

[0004] Ogshi et al. studied the host-guest properties of pillar[5]arene and viologen and pyridinium salt derivatives. The viologen moiety in the structure of dioctylviologen (C8BpyC8) can enter the cavity of pillar[5]arene, thereby interacting with pillar[5]arene. [5] Aromatics form host-guest complexes, but the structure of viologens is slightly complex, and some viologen structures such as adamantyl viologens (AdBpyAd) have too large adamantyl groups to enter the cavity of pillar [5] aromatics , cannot form host-guest complexes with pillar [5] arenes [T.Ogoshi, et al, Para-Bridged Symmetrical Pillar[5]arenes: Their Lewis Acid Catalyzed Synthesis and Host-Guest Property[J].J.Am.Chem. Soc.2008,130,5022-5023.】

Method used

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  • Acid/base double stimulation responsive nanometer container and preparation method thereof
  • Acid/base double stimulation responsive nanometer container and preparation method thereof
  • Acid/base double stimulation responsive nanometer container and preparation method thereof

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preparation example Construction

[0037] References for the preparation method of mesoporous silica nanospheres of the present invention [C D Ding; Y Liu; M DWang; T Wang; J J Fu; Superhydrophobic Coating Based on Mechanized Silica Nanoparticles for Reliable Protection of Magnesium Alloy[J].J. Am.Chem.Soc.,2016,4(21):8041-8052], the specific steps are as follows:

[0038] With 0.5g cetyltrimethylammonium bromide (CTAB), 1.75mL 2mol / L sodium hydroxide solution, 240mLH 2 O was added to a 500mL three-necked flask, heated to 80°C under vigorous stirring, and kept for 30 minutes to activate CTAB, and then 2.5mL tetraethyl orthosilicate (TEOS) was added dropwise. Under vigorous stirring, white precipitates gradually appeared in the reaction vessel. generate. React at 80°C for 2 hours, filter while hot, wash the solid with water and methanol several times, and dry it in vacuum. After drying, ultrasonically disperse the solid in a mixture of 100mL methanol and 5mL concentrated hydrochloric acid, stir the reaction so...

Embodiment 1

[0040] 1. Preparation of guest molecules

[0041] Weigh 0.6g of sodium hydroxide, measure 0.97mL of 6-chloro-1-n-hexanol and 5mL of water, and mix them in an ice bath. Weigh 1.5g of p-toluenesulfonyl chloride and dissolve it in 5mL of tetrahydrofuran, add it to the above mixed solution, and control the dropping time to 30min. After reacting for 2 h, it was extracted twice with dichloromethane, the collected organic phase was washed with water, and dried over anhydrous sodium sulfate. The solvent was removed by rotary evaporation, and dried under vacuum at 40°C. 1.5 g of yellow liquid was obtained as the product 6-p-toluenesulfonyl-1-chlorohexane.

[0042] The above product 6-p-toluenesulfonyl-1-chlorohexane (21.78mg 0.075mmol) 1-methylimidazole (4.1mg0.05mmol) was dissolved in 15mL toluene, and reacted at 90°C for 30h. After the reaction had cooled to room temperature, the product was washed with ethyl acetate (4×20 mL) and dried in vacuo. The white waxy product 1-methyl-3...

Embodiment 2

[0056] 1. Preparation of guest molecules

[0057] Weigh 1.2g of sodium hydroxide, measure 3.94mL of 6-chloro-1-n-hexanol and 10mL of water, and mix them in an ice bath. Weigh 3g of p-toluenesulfonyl chloride and dissolve it in 10mL of tetrahydrofuran, add it into the above mixed solution, and control the dropping time to 60min. After reacting for 2 hours, it was extracted twice with dichloromethane, and the collected organic phase was washed with water and dried over anhydrous sodium sulfate. The solvent was removed by rotary evaporation, and dried under vacuum at 40°C. 2.9 g of yellow liquid was obtained as the product 6-p-toluenesulfonyl-1-chlorohexane.

[0058] The above product 6-p-toluenesulfonyl-1-chlorohexane (43.56mg 0.15mmol) 1-methylimidazole (8.2mg0.1mmol) was dissolved in 20mL toluene, and reacted at 90°C for 36h. After the reaction had cooled to room temperature, the product was washed with ethyl acetate (4×40 mL) and dried in vacuo. The white waxy product 1-m...

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Abstract

The invention discloses an acid / base double stimulation responsive nanometer container and a preparation method thereof. According to the nanometer container, mesoporous nanometer silicon dioxide is adopted as a framework; a host-guest compound is formed based on host pillar[5]arene and a guest molecular chain 1,6-(1-(1-methyl)imida zolehexyl)hexamethylene diamine; a supramolecular valve is formed on the surface of a microsphere through modification; a metal corrosion inhibitor is loaded in the microsphere; under the action of pH stimulation, macrocyclic pillar[5]arene in the nanometer container can move, thereby achieving controllable release of the metal corrosion inhibitor; and after the metal corrosion inhibitor enters a coating, metal corrosion can be effectively inhibited. The nanometer container disclosed by the invention has the advantages that the function of response to various external stimuluses can be achieved; double response to acid / base stimulation can be achieved; and the prospect of application to the fields of drug delivery, intelligent anti-corrosive coating and the like is broad.

Description

technical field [0001] The invention relates to an acid / alkali dual-stimulus responsive nano container and a preparation method thereof, belonging to the technical field of nano materials. Background technique [0002] Mesoporous silica nanoparticles (MSNs) is a three-dimensional, layered solid material with hexagonal ordered mesopores. The rigid and stable structure makes it resistant to bacterial contamination. The pores can be loaded with molecules, and the loaded molecules can be protected in a stable framework to prevent denaturation caused by changes in the external environment. It has the advantages of good biocompatibility, chemical stability, light transmittance, and high specific surface area. , are used in catalysts, dye-doped imaging and remote sensing, adsorption, frequency conversion light emitting devices, detection, intelligent anti-corrosion coatings and other biological or medical diagnostic systems. [0003] In recent years, the study of supramolecular sw...

Claims

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Application Information

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IPC IPC(8): C23F11/14B82Y30/00B82Y40/00
CPCB82Y30/00B82Y40/00C23F11/149
Inventor 傅佳骏仝玲丁晨迪王明东宫光彩冯晶
Owner NANJING UNIV OF SCI & TECH
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