Preparation method and application of mesoporous calcium carbonate pharmaceutical composition modified by hyaluronic acid
A technology of hyaluronic acid modification and hyaluronic acid, applied in the field of medicine, can solve the problems of low tumor targeting and poor water dispersibility, and achieve the effects of simple preparation process, low production cost, and huge economic and social benefits.
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Embodiment 1
[0020] The preparation method of the mesoporous calcium carbonate pharmaceutical composition modified by hyaluronic acid of the present invention comprises the following steps:
[0021] (1) Add 0.66g of CaCl 2 Dissolved in 1000ml water, configured as CaCl 2 solution; 0.63g of Na 2 CO 3 Dissolved in 1000ml water, configured as Na 2 CO 3 Solution: Dissolve 2.5g of soluble starch in 1000ml of water to form a soluble starch solution;
[0022] (2) The CaCl configured in step (1) 2 Mix 125ml of solution with 125ml of soluble starch solution, stir for 30min, then add 125ml of Na 2 CO 3 The solution was vigorously stirred for 15 minutes and left to stand for 24 hours; centrifuged at 12,000 rpm for 5-10 minutes to obtain a precipitate, which was redissolved in ultrapure water, then centrifuged and redissolved, and repeated twice, freeze-dried to obtain mesoporous calcium carbonate nanoparticles MCC;
[0023] (3) Ultrasonically disperse 170mg of mesoporous calcium carbonate nano...
Embodiment 2
[0028] The preparation method of the mesoporous calcium carbonate pharmaceutical composition modified by hyaluronic acid of the present invention comprises the following steps:
[0029] (1) Add 0.6g of CaCl 2 Dissolved in 1000ml water, configured as CaCl 2 solution; 0.6g of Na 2 CO 3 Dissolved in 1000ml water, configured as Na 2 CO 3 Solution: Dissolve 2 g of soluble starch in 1000 ml of water to form a soluble starch solution;
[0030] (2) The CaCl configured in step (1) 2 Mix 100ml of solution with 100ml of soluble starch solution, stir for 20min, then add 100ml of Na 2 CO 3The solution was vigorously stirred for 10 minutes and left to stand for 22 hours; centrifuged at 12,000 rpm for 5 minutes to obtain a precipitate, which was redissolved in ultrapure water, then centrifuged and redissolved, and repeated twice, freeze-dried to obtain mesoporous calcium carbonate nanoparticles MCC;
[0031] (3) Ultrasonic disperse 140mg of mesoporous calcium carbonate nanoparticles ...
Embodiment 3
[0036] The preparation method of the mesoporous calcium carbonate pharmaceutical composition modified by hyaluronic acid of the present invention comprises the following steps:
[0037] (1) Add 0.7g of CaCl 2 Dissolved in 1000ml water, configured as CaCl 2 solution; 0.7g of Na 2 CO 3 Dissolved in 1000ml water, configured as Na 2 CO 3 Solution: Dissolve 3 g of soluble starch in 1000 ml of water to form a soluble starch solution;
[0038] (2) The CaCl configured in step (1) 2 Mix 150ml of solution with 150ml of soluble starch solution, stir for 40min, then add 150ml of Na 2 CO 3 The solution was vigorously stirred for 20 minutes, and left to stand for 26 hours; centrifuged at 12,000 rpm for 10 minutes to obtain a precipitate, which was redissolved in ultrapure water, centrifuged and redissolved again, and so repeated 3 times, freeze-dried to obtain mesoporous calcium carbonate nanoparticles MCC;
[0039] (3) Ultrasonically disperse 200mg of mesoporous calcium carbonate n...
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