212 results about "Corneal contact lens" patented technology

An improved corneal contact lens for use in orthokeratology wherein the lens has an anterior surface, posterior surface and includes a tear zone which defines a tear reservoir located on the posterior surface of the lens. The improvement involves providing at least one fenestration surface located in the tear zone which defines an opening extending through the contact lens from the anterior surface to the posterior surface. The openings in the tear zone relieve fluid pressure which was found to cause certain symptoms, such as lens adhesion, tightening and general wearing discomfort. The fenestrations in the tear zone provide enhanced wearing comfort without adversely affecting the cornea-shaping properties of the lens.

A corneal contact lens for use in treating myopia by controlled corneal molding. The lens includes a central zone having a central zone radius of curvature and a tear zone. The tear zone is located concentrically around the central zone and has a radius of curvature which is smaller than the central zone. A transition zone is provided between the central zone and the tear zone wherein the transition zone has at least one transition ring. The lens may also include a peripheral zone which is located concentrically around the tear zone wherein the peripheral zone includes multiple peripheral curves having radii of curvature equal to or greater than the central zone.

Disclosed is a device adapted to measure intraocular pressure comprising: a corneal contact lens having a pressure sensor mounted in a recess or cavity in the contact lens, and wherein the contact lens has a back surface which is formed so as to protrude in a desired portion beyond the profile of the adjacent part of the lens and thus to press against the cornea, which protruding portion experiences a reactive deformation which is detected directly or indirectly by the pressure sensor.

The invention discloses a high oxygen-permeability fluorosilicone hydrogel contact lens material and a preparation method thereof. The high oxygen-permeability fluorosilicone hydrogel contact lens material is obtained by crosslinking copolymerization of a fluorine-containing polysilicone monomer with hydrophilic groups and ends capped by methacrylate and one or more hydrophilic monomers and siloxane monomers initiated by ultraviolet light or heat. The content of a fluorosilicone amphiphilic monomer in the mixed monomers is 20%-60%. The preparation method comprises the following steps: evenly mixing the fluorosilicone amphiphilic monomer, the hydrophilic monomers, the siloxane monomers, a crosslinking agent, an initiator and a diluent, injecting the mixture into a mold, initiating polymerization by ultraviolet irradiation or heat, then demolding, removing unreacted monomers or oligomers, and immersing in water to obtain hydrogel. The hydrogel material has high oxygen permeability, wettability, proteinosis resistance and the like, and is a corneal contact lens with excellent properties.

The invention discloses a silicon hydrogel material having high oxygen permeability. The silicon hydrogel material is prepared, through a polymerization reaction, from following components including, by mass, 10-40 parts of an amphipathic macro-molecular silicon monomer, 10-30 parts of a small-molecular silicon monomer, 40-80 parts of a hydrophobic monomer, 0-30 parts of an organic solvent, and an initiator and a crosslinking agent. The silicon hydrogel material and a corneal contact lens have the high oxygen permeability, are low in cost and are easy to prepare.

The invention discloses a chitosan derivative with cross-linking polymerization and containing drug ligand. The chitosan derivative is a grafted substance formed by grafting a methacrylic acid substance and beta-cyclodextrin on a chitosan main chain, wherein the beta-cyclodextrin is grafted on the chitosan main chain through epoxy chloropropane; and the methacrylic acid substance is hydroxyethyl methylacrylate or methacrylic anhydride. The chitosan derivative provided by the invention has the beneficial effects that the processibility is good, and the controlled release of hydrophobic drugs can be realized; a hydrogel corneal contact lens prepared by the chitosan derivative has the advantages that the transparency is good, the water content, the water-retaining property and protein absorption capability are balanced, and the loading capability and the controlled release capability to the drugs are better than those of the existing material obviously. The chitosan derivative disclosed by the invention has the advantages that the synthetic route is simple, the operability is strong and the social and economic benefits are larger.

The present invention discloses a hydrophilic siloxane oligomer, the siloxane oligomer and various hydrophilic monomers can be well intermixed without a solvent for helping solubilization, a silicon hydrogel material with good light transmission can be prepared; a silicon hydrogel is also provided, the silicon hydrogel is prepared from 5 to 45 parts of the siloxane oligomer, 55 to 95 parts of a hydrophilic monomer, 0 to 20 parts of a small molecule silicon monomer, and an initiator and a crosslinking agent by polymerization reaction; the silicon hydrogel has a good hydrophilic property and oxygen permeability; meanwhile a corneal contact lens is also provided, the corneal contact lens is prepared from the silicon hydrogel material, and the corneal contact lens has good oxygen permeability, strong hydrophilicity and wearing comfortability.

Disclosed is a device adapted to measure intraocular pressure comprising: a corneal contact lens having a pressure sensor mounted in a recess or cavity in the contact lens, and wherein the contact lens has a back surface which is formed so as to protrude in a desired portion beyond the profile of the adjacent part of the lens and thus to press against the cornea, which protruding portion experiences a reactive deformation which is detected directly or indirectly by the pressure sensor.

The invention provides a design method for a cornea contact lens based on a wave front technology. The method is a technology for obtaining a surface type structure of the cornea contact lens according to an objective measurement data of eye vision light; according to actually measured corneal topography data, optimum spherical or circular fitting is processed for the cornea front surface by MATLAB software programming to design the surface type structure of an optical region on the back surface of the cornea contact lens. The spreading of the wave front that is transmitted to the cornea front surface from the exit pupil plane through a tear lens and a cornea contact lens medium is calculated according to the actually measured wave front aberration data of human eyes based on a diffractive angular spectrum theory so as to obtain the equivalent wave front aberration of the front surface of the cornea contact lens and then fit to figure out the optimum curved surface type of the optical region on the front surface of the cornea contact lens for correcting the wave front aberration of eye; and the optimum sphericity, column degree and parallactic angle of an astigmatism axis of the cornea contact lens are figured out for the cornea contact lens by calculating and fitting the designed surface type structures for optical region on the front and back surfaces of the cornea contact lens.

A pupil reduction corneal contact lens having a light-admitting central area surrounded by a light-blocking area. The central area can be clear or have a slight tint for reducing glare that would not reduce visual acuity to 20 / 25 or less. The lenses can be soft, gas-permeable or hard.

The invention discloses a 24-hour intraocular pressure monitoring sensor based on fiber gratings. The 24-hour intraocular pressure monitoring sensor based on the fiber gratings comprises a soft corneal contact lens, an optical fiber and a plurality of fiber gratings, wherein the corneal contact lens is spherical crown-shaped and used for fitting with the eyeball of a patient in a shape matching mode when wearing; the optical fiber is embedded in the lens layer of the corneal contact lens, the body is arrayed in an Achimedean spiral mode around the center of the contact lens, and the tail end thereof is led out to serve as an interaction port; the fiber gratings are arranged on the optical fiber at intervals, when the eyeball is deformed due to intraocular pressure undulation, the fiber gratings bear the corresponding stress change, and corresponding feedback optical wave signals are output through the tail port of the optical fiber. The 24-hour intraocular pressure monitoring sensor based on the fiber gratings is capable of realizing real-time high-precision measurement for the pressure of multiple sites according to the reflection wavelength change, and meanwhile, the 24-hour intraocular pressure monitoring sensor based on the fiber gratings has advantages of high sensitivity, large dynamic range, good stability, comfortable use, small volume, light weight and the like.

The invention discloses blue light absorbent and belongs to the technical field of corneal contact lenses. The blue light absorbent is prepared from a compound in the following general formula (please see the general formula in the specification). The invention further discloses a blue-light prevention corneal contact lens containing the blue light absorbent and a manufacturing method of the blue-light prevention corneal contact lens. The novel blue light absorbent is adopted, and the defects that existing blue light absorbent is poor in intermiscibility, prone to running off, poor in biocompatibility and the like are overcome; due to the fact that unsaturated double bonds are contained in the novel blue light absorbent and the blue light absorbent can participate in polymerization of the lens, the running-off phenomenon occurring in the later-stage treatment and using processes of the blue light absorbent is effectively avoided, and the damage to the eyes due to release of the blue light absorbent in the wearing process is effectively prevented. By means of the preparing method of the corneal contact lens, the indexes such as the light transmittance, the oxygen permeation coefficient, the focal power definition and liposuction performance of the prepared lens are better than those achieved through an existing method, and good practicability is achieved.

The invention discloses a corneal contact lens drug carrier with bionic characteristics. The carrier is formed by carrying out polymerization on a cyclodextrin derivative containing double bonds, phosphorylcholine, hydroxyethyl methacrylate and an initiator, wherein the average functionality of the double bonds in the cyclodextrin derivative containing the double bonds is 1.1-1.5; the mass of phosphorylcholine is 0.1-1% of the total mass of the cyclodextrin derivative containing the double bonds and hydroxyethyl methacrylate; the mass ratio of hydroxyethyl methacrylate to the cyclodextrin derivative containing the double bonds is (1-20): 1; the initiator comprises ammonia sulfate and tetramethyl ethylenediamine. The invention provides the novel corneal contact lens drug carrier with good oxygen permeation performance and drug controlled release capability; the obtained product is in accordance with the basic requirements of a corneal contact lens and is capable of controlling the release of eye ointment. The corneal contact lens drug carrier with bionic characteristics has higher social benefit and economic benefit.

The invention provides a corneal contact lens nursing composition containing mycose, and also relates to the compositions of the type. The composition comprises the following components in weight percent: 0.001-8% of mycose, 0.01-3% of isotonic regulator, 0.001-4% of buffering agent, 0.01-3% of lubricating moisturizing agent, 0.001-1% of complexing agent, 0.01-1% of surface active agent and 0.00001-0.15% of antimicrobial agent. The invention is used for the storage, sterilization, cleaning, lubrication, moisture preservation and dry resistance of the lens of the corneal contact lens and for the rehumidification of the lens, can relieve the dryness and acid bilges of the eyes, reduce the death rate of the corneal epithelial cell in a dry environment, and improve the restoration of the corneal epithelial and intradermal cells.

The invention relates to a corneal contact lens achieving controlled drug release. The corneal contact lens comprises a semipermeable membrane layer, a water-absorbing expansion layer, an impermeableelastic membrane layer and a drug storage layer which are arranged in sequence from bottom to top; the drug storage layer is provided with a storage cavity used for storing drugs and a microchannel allowing the drugs to flow out, the semipermeable membrane layer makes contact with the cornea, and allows water in tears to enter the water-absorbing expansion layer, the elastic membrane layer isolates the storage cavity of the drug storage layer and the water-absorbing expansion layer, when the water-absorbing expansion layer absorbs the water in the tears to expand, the storage cavity is compressed through the elastic membrane layer, and the drugs can be lowly released to the eye through the microchannel. Accordingly, drug release is conducted on the eye in a non-invasive mode, and pain of apatient in an operation is avoided; drug release is achieved through imbibition actuating, and can last for longer time, and more and diverse drugs can be stored.

The invention discloses a multi-base arc corneal contact lens, and belongs to correction control glasses. The multi-base arc corneal contact lens is a hard contact lens or a soft contact lens, wherein the diameter of an inner lens surface base arc area is 6.0-9.0mm; two or three base arcs are prepared; a side arc is prepared on the edge of an inner lens surface; a concentric circular contact lens or a monochromatic light contact lens is prepared on a refraction surface; a central area and a peripheral area are prepared on the concentric circular contact lens; the diameter of the central area is 0.8-3.0mm, and the refractive diopter is + / -0.00D to -20.00D; in a region with the diameter within 6.0-9.0mm in the peripheral area, three or four concentric arcs of which the width ranges from 0.2mm to 1.5mm are prepared; hybrid arcs of which the width is 0.2-1.0mm are prepared between two concentric arcs; the peripheral area is prepared in a manner of positive additional values relative to the central area; the positive additional values are gradually and uniformly increased at the concentric arcs.

Four-quadrant peripheral defocus contact lenses are corneal contact lenses. The surface shape of the contact lens of the present invention includes an optical zone and a fixed zone, the diameter of the optical zone is 6.0mm to 8.0mm, including 1 central zone and 4 quadrant zones, the diameter of the central zone is 0.8mm to 3.0mm, and the width of each quadrant zone is 1.0mm to 3.0mm mm, where the central area is prepared from 0.00D to ‑6.00D, the 4 quadrants are positively added relative to the central area, the upper quadrant is positively added +0.05D to +1.00D, and the lower quadrant is positively added Prepare +0.07D to +2.00D, prepare +0.09D to +3.00D in the positive quadrant area of ​​the temporal side, and prepare +0.11D to +3.50D in the positive quadrant area of ​​the nasal side, and prepare 4 diopters with different diopters For the quadrant area, prepare the full quadrant area aspheric surface, defocus the temporal nasal quadrant area or adjust the hysteresis defocus contact lens.

The invention discloses a contact lens for treating xerophthalmia. The contact lens is a ball coronary-shaped corneal contact lens (1) which is mainly composed of a soft layer (7) and a hard layer (8), wherein the two parts are made in manners of plane bonding and hot-press molding; a micro-fluid channel (3) and a hollow cavity (4) are formed inside the contact lens; the hollow cavity (4) is filled with a liquid medicine (5); one end of the micro-fluid channel (3) is communicated with the hollow cavity (4); and the other end of the micro-fluid channel (3) is communicated with a liquid outlet (2), and thus the micro-fluid channel (3) is communicated with outside of the corneal contact lens (1). Through reasonable arrangement and improvement of materials of contact lenses and internal structures of lens pieces, the contact lens is used as a medicine delivery system, and compared with a conventional treatment mode of eye drops, the contact lens has the advantages that multiple inconveniences of conventional eye drop treatment modes are overcome, the biological utilization rates of medicines are effectively increased, the retention times of the medicines on corneas are prolonged, and automatic and long-lasting medicine administration treatment on patients suffering from xerophthalmia is achieved.

The invention relates to a corneal contact lens comprehensive detector and a focusing evaluating algorithm of the corneal contact lens comprehensive detector. The corneal contact lens comprehensive detector comprises an optical imaging device, an electronic ocular, an objective table, a lifting device, a digital dial indicator, a singlechip and a tablet personal computer and corresponding measuring control software, wherein a collimation light pipe is arranged between the ocular and an objective lens; an LED (light-emitting diode) oblique incidence lighting device and a dark filed lighting device are also respectively arranged above and below the objective table; a digital dial indicator probe is contacted with the objective table, and a digital signal is output to a controller; the lifting device comprises a vertical arm fixed on a base, guide rails and a stepping motor arranged on the vertical arm, and a gear and rack transmission device which realizes the variable speed lifting by switching an electromagnetic clutch, and the stepping motor and the electromagnetic clutch are controlled by a controller. The corneal contact lens comprehensive detector and the focusing evaluating algorithm of the corneal contact lens comprehensive detector provided by the invention have the advantages that a lens surface quality detection function and a lens diameter measuring function are also integrated, the intelligent measurement of a lens is realized, and the detection efficiency and measurement accuracy are improved.

The invention discloses a hydrogel corneal contact lens drug carrier, which is prepared by polymerization of a double bond-containing chitosan derivative, hydroxyethyl methacrylate and N-vinyl pyrrolidone in the presence of an initiator. Terpolymer hydrogel provided by the invention has good water absorbing swelling and transparence after polymerization, no obvious deformation, good water retention properties, high oxygen permeability value, large amount of drug loading, and stronger anti-protein adsorption ability than that of bipolymer hydrogel. The performances of the novel hydrogel corneal contact lens drug carrier with good oxygen permeability and controlled release drug capabilities meet the basic requirements of corneal contact lens, the release of eyedrops can be controlled, and the social and economic benefits are greater.

The invention discloses an intraocular tension testing method and an intraocular tension testing device based on a magnetic interaction. The method comprises the following steps: (1) wearing a corneal contact lens embedded with an inner magnetic disk to make the inner magnetic disk closely contact with the corneas; (2) placing another outer magnetic disk in front of the eyes perpendicular to the inner magnetic disk to make the two magnetic disks form a mutually repulsion force field; and (3) with the movement of the outer magnetic disk, picking up a repulsive force curve by a pressure sensor, and calculating the intraocular tension value through the inflexion point or the slope change of the curve. In the technical scheme of the invention, the outer magnetic disk is driven to move forward or backward by a built-in straight-line motion mechanism to adjust the repulsive force between the outer magnetic disk and the inner magnetic disk so as to realizing pressure application without contacting, and the measuring head can not directly contact with the eyeballs, thereby causing no pain; the invention does not require the testing of a doctor, the patient can operate individually, and the device can automatically calculate and store the measured intraocular tension value. When the invention is used, the intraocular tension can be tested by the method of calculating and obtaining the intraocular tension value through the curve of the repulsive force between the inner magnetic disk in the corneal contact lens and the moving outer magnetic disk, and the testing result can be accurate and reliable by performing the intraocular tension testing for five times and taking the average value.

The invention relates to a comfortable corneal contact lens for treating myopia and aims at providing the corneal contact lens with the characteristics of comfortableness, high permeability and difficult damage. The technical scheme is as follows: the corneal contact lens comprises a rigid lens and a soft edge, wherein the rigid lens is rotor-shaped and is made of breathable rigid materials; the soft edge is made of hydration polymer and covers the peripheral area of the rigid lens; and a tear area for containing tears is arranged between the rigid lens and the soft edge.

The invention relates to a simultaneous interpenetrating silicon hydrogel and a preparation method thereof, and the synchronous forming of two networks can be triggered by simple light or heat. One network is a hydrophilic network, and obtained by free radical polymerization; the other network is obtained by a chemical reaction between polyisocyanate as a crosslinking agent and hydroxyl containing polysiloxane, and specifically, is prepared by mixing the hydroxyl containing polysiloxane, a polymerization monomer and the crosslinking agent, and adding an initiator, a catalyst and the like for one-step curing. The hydrophilic network gives the material water absorbing and ion permeation properties; and the organosilicone network gives the material high oxygen permeability. The simultaneous interpenetrating silicon hydrogel has good biocompatibility, and can be used for biomedical materials, such as a corneal contact lens, medical implant materials, artificial skin, a drug delivery carrier and the like.

The invention belongs to the field of biomedical materials, and particularly relates to a drug-sustained-releasing type corneal contact lens hydrogel material, a preparing method and an application. The preparing method of the drug-sustained-releasing type corneal contact lens hydrogel material includes the following steps: synthesizing sulfated-beta-cyclodextrin; synthesizing aminated-beta-cyclodextrin; synthesizing beta-cyclodextrin functional hyaluronic acid; preparing the drug-sustained-releasing type corneal contact lens hydrogel material. According to the drug-sustained-releasing type corneal contact lens hydrogel material prepared with the preparing method, poly-hydroxyethyl methacrylate hydrogel serves as a base body, and the compound hydrogel material of an interpenetrating network structure is constructed by introducing the beta-cyclodextrin functional hyaluronic acid into the base body; the novel corneal contact lens material has the advantages that hydrophily is good, xerophthalmia is prevented, inflammations caused by tear protein adsorption are suppressed, and drugs are loaded and continuously released for a long time; the hydrogel material is suitable for long-time wearing and is of great significance in eye disease treatment.

The invention provides a corneal contact lens preserving liquid composition which is characterized by being composed of the following components in weight percent: 0.001-10% of mycose, 0.001-5% of lubricating moisturizing agent, 0.01-4% of isotonic regulator, 0.001-10% of buffering agent and 70-99.9% of pure water. The preparation method of the corneal contact lens preserving liquid composition is as follows: placing the above components into pure water in turn for dissolving; adjusting the pH value to a range of 6.5-7.8 with sodium hydroxide and hydrochloric acid, wherein the osmotic pressure is 280-320mosm / kg.H2O; and degerming and filtering the solution with 0.22mu m of degerming objects to obtain the product. The invention has the functions of preserving, lubricating and moisturizing the lens of corneal contact lens and can relieve the dryness of eyes.

The invention discloses a non-invasive ocular pressure detection sensor based on a micro-fluidic technology. The detection sensor comprises a corneal contact lens, a spiral inductor, a fringing capacitor and an inner ring capacitor, wherein cavities and a micro-fluidic channel are arranged in the corneal contact lens; the cavities and the micro-fluidic channel communicate and are used for keeping fluid, and the fluid is conveyed into the micro-fluidic channel; the amount of the fluid which is conveyed into the micro-fluidic channel is affected by ocular pressure , and capacitance of the inner ring capacitor varies with the amount of the fluid which is conveyed into the micro-fluidic channel; and a CLC loop is constituted by the fringing capacitor, the spiral inductor and the inner ring capacitor, so that the ocular pressure is detected. With the application of the ocular pressure detection sensor disclosed by the invention, the problem that the ocular pressure sensor is inconvenient for night supervision is effectively solved, and the fluctuation of the ocular pressure can be measured with high precision in a whole course within 24h; and the detection sensor has the advantages of being simple in structure, convenient to manufacture, high in sensitivity and broad in dynamic scope.

The invention provides a corneal contact lens cleaning device. The corneal contact lens cleaning device comprises a cleaning box body, wherein a transducing piece and two electrodes are arranged in the cleaning box body; the transducing piece is connected with an ultrasonic generating circuit, and the electrodes are connected with an electric field generating circuit. The corneal contact lens cleaning device has the advantages of scientific design, high practicability, reasonable structure, simplicity in operation and good cleaning effect. The invention further provides a cleaning method adopting the corneal contact lens cleaning device. With the adoption of the cleaning method, complete cleaning of the surface and the inside of a corneal contact lens is realized, and the corneal contact lens is disinfected by an acid-alkali solution produced through an electrolytic reaction while the corneal contact lens is cleaned; the cleaning method has the advantages of simplicity in operation and good cleaning effect.

The invention discloses a light-driven oxygen production type corneal contact lens, a preparation method and application thereof, and belongs to the technical field of corneal contact lenses. The light-driven oxygen production type corneal contact lens is composed of a flexible heterojunction photocatalytic electrode and a silicon-based hydrogel matrix. The preparation method includes: firstly, sputtering a p-type semiconductor and an n-type semiconductor to two faces of a flexible center interlayer through a magnetron sputtering method to prepare the flexible heterojunction photocatalytic electrode, then coating the flexible heterojunction photocatalytic electrode with a passivation layer and performing packaging into the silicon-based hydrogel matrix, and conducting machining and formingto obtain the light-driven oxygen generation type corneal contact lens. According to the invention, the oxygen supply mode that the traditional corneal contact lens carries oxygen with water or allows oxygen to permeate through a channel is changed into a self-oxygen-production oxygen supply mode, so that the wearing comfort and durability of the corneal contact lens are improved. The light-driven oxygen generation type corneal contact lens can absorb harmful light (ultraviolet light) or strong light (blue light and laser) to protect eyes; and the generated high active oxygen, hydrogen and the like have prevention and treatment effects on ophthalmic diseases (keratitis, conjunctivitis and glaucoma) caused by bacteria and viruses.