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Drug-sustained-releasing type corneal contact lens hydrogel material, preparing method and application

A technology of corneal contact lens and hydrogel, which is applied in the field of biomedical materials, can solve the problems of limited drug absorption ability of contact lens, can not meet the needs of practical application, and low water absorption rate of pHEMA, so as to prevent dry eye syndrome, which is of great significance and The effect of suppressing inflammation

Active Publication Date: 2015-12-02
GUANGZHOU YUEQING REGENERATION MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Initially, people wear the pHEMA contact lens on the eyeball after absorbing the drug solution to a saturated state, or wear the pHEMA contact lens on the eyeball and then add ordinary eye drops. The drug is first absorbed by the corneal contact lens on the eyeball, and then released into the In tears, but pure pHEMA has a low water absorption rate, the contact lens has limited ability to absorb drugs, and the phenomenon of "burst release" of drugs in the early stage is serious, so it cannot meet the needs of practical applications
Although people tried to improve the hydrophilicity and drug-loading capacity of contact lenses by copolymerizing HEMA monomers with methacrylic acid, methyl methacrylate, N-vinylpyrrolidone and other monomers, the effect was not ideal.

Method used

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  • Drug-sustained-releasing type corneal contact lens hydrogel material, preparing method and application
  • Drug-sustained-releasing type corneal contact lens hydrogel material, preparing method and application
  • Drug-sustained-releasing type corneal contact lens hydrogel material, preparing method and application

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Experimental program
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Effect test

Embodiment 1

[0059] (1) Slowly add 20 mL of 0.33 g / mL NaOH solution dropwise to 500 mL of β-CD suspension with a concentration of 0.12 g / mL, and the suspension slowly becomes clear; add 30 mL of paraformaldehyde with a concentration of 0.34 g / mL The acetonitrile solution of phenylsulfonyl chloride (p-TsCl) was added dropwise to the above clarified solution, and a white precipitate was gradually formed, and then the reaction was stirred for 2 h; the unreacted p-TsCl was separated by suction filtration under reduced pressure, and the filtrate was placed in 4 After standing in the refrigerator for 48h, a large amount of white precipitate was precipitated; the precipitate was collected by vacuum filtration again, and dried in vacuum for 48h to obtain the product Mono-6-O-Ts-β-CD;

[0060] in, figure 1 for Mono-6-O-Ts-β-CD 1 HNMR spectra, such as figure 1 As shown in the middle spectrum, the proton peaks of Mono-6-O-Ts-β-CD are assigned as follows: 2.42ppm (H-9'), 3.24~3.67ppm (H-2'~H-6'), 4....

Embodiment 2

[0068] (1) Slowly add 20 mL of 0.33 g / mL NaOH solution dropwise to 500 mL of β-CD suspension with a concentration of 0.12 g / mL, and the suspension slowly becomes clear; add 30 mL of paraformaldehyde with a concentration of 0.34 g / mL The acetonitrile solution of phenylsulfonyl chloride (p-TsCl) was added dropwise to the above clarified solution, and a white precipitate was gradually formed, and then the reaction was stirred for 4 h; the unreacted p-TsCl was separated by suction filtration under reduced pressure, and the filtrate was placed in 4 After standing in the refrigerator for 48h, a large amount of white precipitate was precipitated; the precipitate was collected by vacuum filtration again, and dried in vacuum for 48h to obtain the product Mono-6-O-Ts-β-CD;

[0069] (2) Dissolve 2.26 mmol of Mono-6-O-Ts-β-CD obtained in step (1) and 51.6 mmol of hexamethylenediamine (HDA) in 12 mL of dimethylformamide, and stir and react at 60°C for 8 h, Then an excess of cold acetone wa...

Embodiment 3

[0073] (1) Slowly add 20 mL of 0.33 g / mL NaOH solution dropwise to 500 mL of β-CD suspension with a concentration of 0.12 g / mL, and the suspension slowly becomes clear; add 30 mL of paraformaldehyde with a concentration of 0.34 g / mL The acetonitrile solution of phenylsulfonyl chloride (p-TsCl) was added dropwise to the above clear solution, and a white precipitate gradually formed. Then the reaction was stirred for 8 hours; the unreacted p-TsCl was separated by suction filtration under reduced pressure, and the filtrate was placed in a refrigerator at 4 °C for 48 hours, and a large amount of white precipitate was precipitated; The product Mono-6-O-Ts-β-CD was obtained;

[0074] (2) Dissolve 2.26 mmol of Mono-6-O-Ts-β-CD obtained in step (1) and 51.6 mmol of hexamethylenediamine (HDA) in 12 mL of dimethylformamide, and stir and react at 80°C for 2 h, Then an excess of cold acetone was added to separate out a white precipitate, and the white precipitate was isolated by suction ...

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Abstract

The invention belongs to the field of biomedical materials, and particularly relates to a drug-sustained-releasing type corneal contact lens hydrogel material, a preparing method and an application. The preparing method of the drug-sustained-releasing type corneal contact lens hydrogel material includes the following steps: synthesizing sulfated-beta-cyclodextrin; synthesizing aminated-beta-cyclodextrin; synthesizing beta-cyclodextrin functional hyaluronic acid; preparing the drug-sustained-releasing type corneal contact lens hydrogel material. According to the drug-sustained-releasing type corneal contact lens hydrogel material prepared with the preparing method, poly-hydroxyethyl methacrylate hydrogel serves as a base body, and the compound hydrogel material of an interpenetrating network structure is constructed by introducing the beta-cyclodextrin functional hyaluronic acid into the base body; the novel corneal contact lens material has the advantages that hydrophily is good, xerophthalmia is prevented, inflammations caused by tear protein adsorption are suppressed, and drugs are loaded and continuously released for a long time; the hydrogel material is suitable for long-time wearing and is of great significance in eye disease treatment.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and particularly relates to a drug sustained-release corneal contact lens hydrogel material, a preparation method and an application. Background technique [0002] Cataracts, glaucoma and other common eye diseases in the world seriously affect human health, and the annual treatment cost is as high as hundreds of billions of dollars. The current treatment methods are mainly intraocular topical administration, that is, conventional eye drops, but there are disadvantages of short drug residence time and low administration efficiency. At the same time, frequent dripping of high-concentration drugs may also have side effects on the human body. The ideal method is to use soft contact lenses to control the sustained release of the drug in the eye area for a long time. Although contact lenses based on polyhydroxyethyl methacrylate (pHEMA) hydrogel or silicone hydrogel have the advantages of high lig...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08J3/075C08G81/00C08B37/08C08B37/16C08F220/28C08F8/30A61L31/04A61L31/14G02C7/04
Inventor 赵剑豪李锐聪容建华
Owner GUANGZHOU YUEQING REGENERATION MEDICINE TECH CO LTD
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