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Simultaneous interpenetrating silicon hydrogel and preparation method thereof

A silicon hydrogel and hydrogel technology, applied in the field of synchronous interpenetrating silicon hydrogel and its preparation, can solve the problems of no synchronous IPN silicon hydrogel, etc., achieve good biocompatibility, and simple preparation process Effect

Inactive Publication Date: 2014-12-03
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After searching the literature, we found that the current IPN materials prepared based on the chemical reaction between hydroxyl and isocyanate are limited to hydrophobic materials (polymethyl methacrylate), and there are no reports on synchronous IPN silicone hydrogels.

Method used

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  • Simultaneous interpenetrating silicon hydrogel and preparation method thereof
  • Simultaneous interpenetrating silicon hydrogel and preparation method thereof
  • Simultaneous interpenetrating silicon hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Weigh a certain amount of hydroxyl-containing siloxane (HPSO), add a certain proportion of polymerized monomer N,N-dimethylacrylamide, 3-(methacryloyloxy)propyltri(trimethylsiloxane)silane (TRIS), ethylene glycol dimethacrylate (EGDMA), isophorone diisocyanate (IPDI) as crosslinking agent, azobisisobutyronitrile (AIBN) as initiator, dibutyltin dilaurate (DBTDL) was used as a catalyst, and stirred evenly to obtain a transparent solution. After vacuum degassing, it was added dropwise into a mold, cured at 80°C for 24 h, opened the mold, put into warm water to remove the film, and extracted unreacted monomers at the same time.

[0039] Table 1. Synchronous interpenetrating silicon hydrogel formulations

[0040]

[0041] After swelling equilibrium, the properties of the prepared membranes were characterized.

[0042] Dehydration process such as figure 1 As shown, in the initial period of time, the water loss was rapid, and the water loss was basically complete after 25...

Embodiment 2

[0047] Weigh a certain amount of hydroxyl-containing siloxane (HPSO), add a certain proportion of polymerized monomers N-vinylpyrrolidone (NVP), 3-(methacryloyloxy)propyl tris(trimethylsiloxane) silane ( TRIS), ethylene glycol dimethacrylate (EGDMA), isophorone diisocyanate (IPDI) as crosslinking agent, azobisisobutyronitrile (AIBN) as initiator, dibutyltin dilaurate ( DBTDL) was used as a catalyst, and stirred evenly to obtain a transparent solution. After vacuum degassing, it was added dropwise into a mold, cured at 80 °C for 24 h, opened the mold, put into warm water for defilming, and extracted unreacted monomers at the same time.

[0048] After the swelling balance, the prepared membrane material was characterized. The prepared gel has good light transmission properties, the water content is 30% to 40%, and the mechanical properties are good.

Embodiment 3

[0050] Weigh a certain amount of hydroxyl-containing siloxane (HPSO), add a certain proportion of polymerized monomers polyethylene glycol methyl ether methacrylate (Mn=300), 3-(methacryloyloxy)propyl tri(trimethyl siloxane) silane (TRIS), ethylene glycol dimethacrylate (EGDMA), isophorone diisocyanate (IPDI) as crosslinking agent, azobisisobutyronitrile (AIBN) as initiator, the Dibutyltin dilaurate (DBTDL) was used as a catalyst, and stirred evenly to obtain a transparent solution. After vacuum degassing, it was added dropwise into a mold, cured at 80°C for 24 h, opened the mold, put into warm water to remove the film, and extracted the untreated reacting monomer.

[0051] After the swelling is balanced, the prepared gel has good light-transmitting properties, the water content is 30%-45%, and the mechanical properties are good.

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Abstract

The invention relates to a simultaneous interpenetrating silicon hydrogel and a preparation method thereof, and the synchronous forming of two networks can be triggered by simple light or heat. One network is a hydrophilic network, and obtained by free radical polymerization; the other network is obtained by a chemical reaction between polyisocyanate as a crosslinking agent and hydroxyl containing polysiloxane, and specifically, is prepared by mixing the hydroxyl containing polysiloxane, a polymerization monomer and the crosslinking agent, and adding an initiator, a catalyst and the like for one-step curing. The hydrophilic network gives the material water absorbing and ion permeation properties; and the organosilicone network gives the material high oxygen permeability. The simultaneous interpenetrating silicon hydrogel has good biocompatibility, and can be used for biomedical materials, such as a corneal contact lens, medical implant materials, artificial skin, a drug delivery carrier and the like.

Description

technical field [0001] The invention relates to a synchronous interpenetrating silicon hydrogel and a preparation method thereof, which is characterized in that there are two mutually independent polymer networks and is prepared by one-step heat or light curing. One of the networks is a hydrophilic network obtained by free radical polymerization; the other network is obtained by a chemical reaction between isocyanate and hydroxyl-containing polysiloxane. The hydrophilic network endows the material with water absorption properties and increases the ion permeability of the material. The silicone network endows the material with high oxygen permeability. The silicone hydrogel involved in this patent has good biocompatibility and can be used in medical biomaterials, such as corneal contact lenses, artificial skin, and drug delivery carriers. Background technique [0002] Silicone hydrogel materials have good biocompatibility, good thermal stability, low glass transition temper...

Claims

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Application Information

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IPC IPC(8): C08L75/04C08L43/04C08G18/61C08G77/38C08F230/08C08F220/54C08F226/10C08F220/28C08F226/02C08J3/28C08J3/24C08J3/075
Inventor 徐金库
Owner QILU UNIV OF TECH
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