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Hydrogel corneal contact lenses drug carrier

A hydrogel cornea and contact lens technology, which is applied in medical science, surgery, etc., can solve the problems of hydrogel elastic modulus drop, easy deformation, and inability to correct vision with corneal contact lenses, and achieve great social benefits and economic benefits. benefit effect

Active Publication Date: 2012-08-15
山东强力日化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, too much water content will cause the elastic modulus of the hydrogel to decrease and be easily deformed, which cannot meet the vision correction requirements of contact lenses. At the same time, hydrophilic monomers will also increase the protein adsorption of contact lenses. , increasing the chance of bacterial growth
In addition, traditional hydrogel contact lenses also lack ligands that interact with drugs

Method used

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  • Hydrogel corneal contact lenses drug carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Add hydroxyethyl methacrylate (HEMA) and N-vinylpyrrolidone (NVP) monomers to the container at a ratio of 7.4:2, and then add 1wt% hydroxyethyl methacrylate modified chitosan Acetic acid aqueous solution of sugar derivatives (CH, double bond graft rate 19%), wherein the quality of the chitosan derivatives is 0.4% of the total mass of HEMA and NVP (M 壳聚糖衍生物 :M HEMA+NVP ); Then add ammonium persulfate (APS), tetramethylethylenediamine (TMEDA) redox initiator that mol ratio is 1:1, wherein the quality of initiator is 0.5% (M of HEMA and NVP total mass APS+TMEDA :M HEMA+NVP ); the whole system adds or maintains the mass content of solvent water to 35% (M Water :M 总体 系 ). Stir the reaction system evenly and pour it into a mold, react at 60° C. for 1 hour, then soak in water for demoulding to obtain a terpolymer hydrogel.

[0053] The gel time of this hydrogel is 25±2min; the transparency is good, and there is no obvious deformation after swelling; the equilibrium water...

Embodiment 2

[0055] Add hydroxyethyl methacrylate (HEMA) and N-vinylpyrrolidone (NVP) monomers to the container at a ratio of 7.4:2, and then add 1wt% hydroxyethyl methacrylate modified chitosan Acetic acid aqueous solution of sugar derivatives (CH, double bond graft rate 25%), wherein the quality of the chitosan derivatives is 0.3% of the total mass of HEMA and NVP (M 壳聚糖衍生物 :M HEMA+NVP ); Then add ammonium persulfate (APS), tetramethylethylenediamine (TMEDA) redox initiator that mol ratio is 1:1, wherein the quality of initiator is 0.5% (M of HEMA and NVP total mass APS+TMEDA :M HEMA+NVP ); the whole system adds or maintains the mass content of solvent water to 35% (M Water :M 总体 系 ). Stir the reaction system evenly and pour it into a mold, react at 60° C. for 1 hour, then soak in water for demoulding to obtain a terpolymer hydrogel.

[0056] The gel time of this hydrogel is 25±2min; the transparency is good, and there is no obvious deformation after swelling; the equilibrium water...

Embodiment 3

[0058] Add hydroxyethyl methacrylate (HEMA) and N-vinylpyrrolidone (NVP) monomers to the container at a ratio of 7.4:2, and then add 2wt% hydroxyethyl methacrylate modified chitosan Acetic acid aqueous solution of sugar derivatives (CH, double bond graft rate 19%), wherein the quality of the chitosan derivatives is 0.4% of the total mass of HEMA and NVP (M 壳聚糖衍生物 :M HEMA+NVP ); Then add ammonium persulfate (APS), tetramethylethylenediamine (TMEDA) redox initiator that mol ratio is 1:1, wherein the quality of initiator is 0.5% (M of HEMA and NVP total mass APS+TMEDA :M HEMA+NVP ); the whole system adds or maintains the mass content of solvent water to 35% (M Water :M 总体 系 ).

[0059] Stir the reaction system evenly and pour it into a mold, react at 60° C. for 1 hour, then soak in water for demoulding to obtain a terpolymer hydrogel. The gel time of this hydrogel is 25±2min; the transparency is good, and there is no obvious deformation after swelling; the equilibrium water...

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Abstract

The invention discloses a hydrogel corneal contact lens drug carrier, which is prepared by polymerization of a double bond-containing chitosan derivative, hydroxyethyl methacrylate and N-vinyl pyrrolidone in the presence of an initiator. Terpolymer hydrogel provided by the invention has good water absorbing swelling and transparence after polymerization, no obvious deformation, good water retention properties, high oxygen permeability value, large amount of drug loading, and stronger anti-protein adsorption ability than that of bipolymer hydrogel. The performances of the novel hydrogel corneal contact lens drug carrier with good oxygen permeability and controlled release drug capabilities meet the basic requirements of corneal contact lens, the release of eyedrops can be controlled, and the social and economic benefits are greater.

Description

technical field [0001] The invention belongs to the technical field of new materials, and in particular relates to the synthesis of contact lenses and the loading and release of medicines in the lenses. Background technique [0002] The treatment of eye diseases is mainly done by drugs at present. In this process, too low drug concentration cannot play a therapeutic role; too high drug concentration will cause side effects and even damage normal tissues and organs. In addition, the therapeutic effect also depends on whether the drug can remain in the affected area for a sufficient time. Among the currently used ophthalmic preparations, more than 90% are eye drops or ointments, which stay in the eyes for only about 2 minutes, and only 1-7% of the drugs can be effectively used. Most of the drugs are discharged through the nasolacrimal duct or The nasal cavity enters the blood system, causing disadvantages such as inconvenient use, low utilization rate, and ineffective therap...

Claims

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Application Information

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IPC IPC(8): A61L31/04A61L31/16C08F290/10C08F220/28C08F226/10
Inventor 胡小红张国俊邱杰
Owner 山东强力日化有限公司
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