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Blue light absorbent, blue-light prevention corneal contact lens containing blue light absorbent and manufacturing method of blue-light prevention corneal contact lens

A technology of contact lenses and blue light absorbers, applied in glasses/goggles, optics, optical components, etc., can solve problems such as loss, difficult biocompatibility evaluation of contact lenses, eye damage, etc., to avoid loss, improve Practicality, overcoming the effect of poor compatibility

Inactive Publication Date: 2016-01-20
HAICHANG CONTACT LENSES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above process shows that the blue light absorber incorporated earlier did not fully participate in the polymerization and was lost during post-processing
In addition, the above phenomenon can easily lead to the continuous release of residual polymer during the wearing process of the contact lens, causing damage to the eyes, making it difficult for the prepared contact lens to pass the biocompatibility evaluation.

Method used

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  • Blue light absorbent, blue-light prevention corneal contact lens containing blue light absorbent and manufacturing method of blue-light prevention corneal contact lens
  • Blue light absorbent, blue-light prevention corneal contact lens containing blue light absorbent and manufacturing method of blue-light prevention corneal contact lens
  • Blue light absorbent, blue-light prevention corneal contact lens containing blue light absorbent and manufacturing method of blue-light prevention corneal contact lens

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 contains PEG 200 Synthesis of Esterified and Acrylic Esterified Azo Blue Light Absorbers

[0034] Its structural formula is:

[0035]

[0036] The first step, the synthesis of diazonium salt

[0037] Under a nitrogen atmosphere, add 150mL of PEG200 / 1,4-dioxane / double distilled water (60 / 30 / 10) mixture into a 250mL three-necked flask, put it in an ice bath, and then add 5.23mL (0.0607 mol) concentrated hydrochloric acid, 4.156g (0.0303mol) carboxyaniline, then add NaNO dropwise 2 (2.30g, 0.0333mol) 10mL aqueous solution was stirred at 5°C for 1h, and a diazonium salt intermediate was formed.

[0038] The second step, the synthesis of azo compounds

[0039] Prepare 150 mL of PEG of phenol (8.5546 g, 0.0909 mol) and NaOH (1.33 g, 0.0333 mol) 500 / 1,4-dioxane / double distilled water (60 / 30 / 10) mixed solution, and then poured into the reacted first step diazonium salt solution, after the mixed solution was stirred for 15min, 350mL of water was added to adjust...

Embodiment 2

[0042] Example 2 contains PEG 200 Synthesis of Azo Blue Light Absorbers Esterified and Esterified with Hydroxyethyl Ethacrylate

[0043] Its structural formula is:

[0044]

[0045] The first step, the synthesis of azo compounds

[0046] Under nitrogen atmosphere, will contain carboxyaniline (0.2866g, 2.09mmol), NaNO 2 (0.19g, 2.85mmol), double distilled water (10mL) of concentrated hydrochloric acid (5mL) was added to tetrahydrofuran:pyridine (5:2) solution of benzoic acid (0.232g, 1.90mmol), stirred at 0°C for 15min, Then it was raised to room temperature, stirred for 48h, and the solvent was removed by rotary evaporation under reduced pressure. The obtained solid was dissolved in ethyl acetate (100mL), and the organic phase was washed with water (3*100mL). The combined organic layers were washed with anhydrous MgSO 4 After drying, the solvent was removed to obtain a red solid, which was recrystallized from dichloromethane-methanol to obtain a pure product.

[0047] T...

Embodiment 3

[0049] Example 3 contains PEG 200 Synthesis of Esterified and Acrylic Amidated Azo Blue Light Absorbers

[0050] Its structural formula is:

[0051]

[0052] The first step, the synthesis of amidated compounds

[0053] Add 2-phenylethylamine (3.96g, 0.0327mol) in 250mL three-necked flask to 100mL methanol solution, stir to make it dissolve completely, add methacrylic anhydride (5.089g, 0.033mol) dropwise in the reaction flask under stirring, After the dropwise addition, react at room temperature for 1 h, add 100 mL of 10% NaCl aqueous solution to it, then add 30 g of NaCl, filter out excess salt after stirring, and place the filtrate in the refrigerator overnight to obtain a white solid, which is mixed with 50:50 cold methanol : washed with water, the filtrate was placed in a refrigerator to obtain a white crystalline solid, combined solids, recrystallized with chloroform, filtered and dried in a vacuum oven to obtain amidated compounds.

[0054] The second step, the syn...

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PUM

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Abstract

The invention discloses blue light absorbent and belongs to the technical field of corneal contact lenses. The blue light absorbent is prepared from a compound in the following general formula (please see the general formula in the specification). The invention further discloses a blue-light prevention corneal contact lens containing the blue light absorbent and a manufacturing method of the blue-light prevention corneal contact lens. The novel blue light absorbent is adopted, and the defects that existing blue light absorbent is poor in intermiscibility, prone to running off, poor in biocompatibility and the like are overcome; due to the fact that unsaturated double bonds are contained in the novel blue light absorbent and the blue light absorbent can participate in polymerization of the lens, the running-off phenomenon occurring in the later-stage treatment and using processes of the blue light absorbent is effectively avoided, and the damage to the eyes due to release of the blue light absorbent in the wearing process is effectively prevented. By means of the preparing method of the corneal contact lens, the indexes such as the light transmittance, the oxygen permeation coefficient, the focal power definition and liposuction performance of the prepared lens are better than those achieved through an existing method, and good practicability is achieved.

Description

technical field [0001] The invention belongs to the technical field of corneal contact lenses, and in particular relates to a blue light absorbing agent, a blue light preventing corneal contact lens containing the blue light absorbing agent and a manufacturing method thereof. Background technique [0002] As the background light source of liquid crystal displays, blue light is widely used in various electronic products, such as computers, smart phones, tablet computers, and TV LED displays. With the popularization of these electronic products and penetration into every aspect of life, people's chances of exposure to blue light have increased dramatically. The damage caused by blue light to the human body, especially the eyes, has gradually attracted everyone's attention. In visible light, blue light is the light closest to ultraviolet light and has the highest energy. Its wavelength is between 400 and 500 nm, and it appears blue in the perception of human eyes. A large num...

Claims

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Application Information

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IPC IPC(8): C08G65/333C07C245/08C08F290/06C08F220/28C08F220/06C08F220/54C08F226/10C08F2/48G02C7/04
Inventor 王富和王志飞韩雪莲江道勇
Owner HAICHANG CONTACT LENSES
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