75 results about "Chemical signaling" patented technology

The invention relates to an experimental device for the jet etching simulation and electrochemical test of a high-temperature high-pressure loop, which belongs to the field of electrochemistry and is particularly applied to the simulation of scouring corrosion conditions of complex parts such as elbows, T joints and the like in pipelines for collecting and delivering petroleum, natural gases and the like to perform high-temperature high-pressure multiphase fluid pipeline part scouring corrosion simulation experiments and perform high-temperature high-pressure fluid scouring corrosion in-situ electrochemical signal tests under scouring condition. The device consists of an autoclave, a heating and heat preservation system, a loop water inlet, a three-electrode system, pipeline connecting flanges, a circulation loop, a high-temperature high-pressure fluid flow meter, a control valve, a fluid outlet, a regenerating pump, a circulating cooling system, a temperature measurement system, a loop water outlet, a spray nozzle, a sample fixture, a control cabinet, a signal transduction path, an external electrochemical workstation and an external high pressure gas cylinder. The device can well simulate the scouring corrosion conditions of a fluid medium in a gas pipeline and test electrochemical signals such as polarization curves, AC impedance and the like of working electrodes under high speed jet condition, and is significant for researches on high-temperature high-pressure fluid scouring corrosion behaviors, rules and mechanisms.

Vascular endothelial growth factor A (VEGFA) is a chemical signal produced by cells that stimulates the growth of new blood vessels, and overexpression of VEGFA can lead to undesirable physiological conditions. Through the identification of new siRNA and modifications that improve the silencing ability of these siRNA in vivo, therapeutic compositions and methods have been invented to address the problems associated with this overexpression.

The invention provides compositions and methods for signal activated RNA interference (saRNAi), preferably in vivo. The invention provides polynucleotides that switches between an inactive form and an active form upon covalent or non-covalent interaction with one or more specific chemical signals, such as disease-specific mRNA, miRNA, or other cellular RNA products with sequences that characterize diseased states of the cell. The interaction between the subject polynucleotides and the signals is preferably mediated by hybridization, which exposes, facilitates the formation, and / or allows the formation of a substrate that can be processed by proteins of the RNAi pathway (such as Dicer). The input and output of multiple different polynucleotides of the invention can form an in vivo signaling network. In addition, the multiple input signals can be integrated to modulate the activity of the subject polynucleotides.