36 results about "Abdominal wall defect" patented technology

The invention relates to the technical field of biological medical engineering, and discloses a biological repairing material for an abdominal wall defect and a preparation method of the biological repairing material. The method comprises the following steps: (1) performing pre-treatment on the muscular tissue of rectus abdominis of a dead animal; (2) performing cell extraction treatment to prepare a skeletal muscle acellular matrix biological thin sheet; (3) dissolving the skeletal muscle acellular matrix biological thin sheet into pepsase for digestion; (4) performing electrostatic spinning on skeletal muscle acellular matrix microparticles obtained by digestion and polycaprolactone to obtain a polycaprolactone / skeletal muscle acellular matrix blended electrostatic spinning fiber film which is the biological repairing material disclosed by the invention. According to the method, a skeletal muscle acellular matrix from abdominal wall tissue and polycaprolactone are combined by an electrostatic spinning technology; the preparation materials can be degraded, and products from degradation are harmless to a human body; the prepared biological repairing material can well simulate constituents and the structure of an extracellular matrix and is good in biocompatibility and biomechanical property.

The invention discloses an absorbable chitin-based composite patch and an application thereof. The absorbable chitin-based composite patch is a mesh composed of chitin-based fibers or threads respectively having a surface coating; the chitin-based fibers or threads are insoluble in water, the main chain of the molecular structure of the chitin-based fibers or threads is polyglucosamine and contains an acyl group and a hydrophilic group, the total molar percent content of the acyl group is greater than or equal to 70%, and the total molar percent content of the hydrophilic group is less than 30%; and the surface coating is a water-soluble aminoglycan coating. The absorbable chitin-based composite patch is implanted in an abdominal wall in the operations of abdominal wall defect repairing and hernia repairing, can reduce the inflammatory response in the acute stage, reduce abdominal adhesions, promote the growth of the tissue cells and the synthesis of an extracellular matrix and accelerate the defect repairing of the abdominal walls in the physiologic repairing stage after the operation, and is gradually degraded after the abdominal wall defect repairing, and degradation products are absorbed and utilized by local tissue cells to further promote the abdominal wall defect repairing, so the absorbable chitin-based composite patch has no residual in bodies after being completely degraded, and no foreign matters exist in the bodies.

The invention provides an emergency treatment device for abdominal wall defect in war wounds, comprising: an anti-adhesion film, a suction tube, a filling layer, and an airbag layer. An airbag layer is arranged on one side, a plurality of suction holes are arranged on the outer wall of one end of the suction tube and extend into the filling layer, and the other end of the suction tube extends outside the filling layer. The use of the anti-adhesion film of hinge antibiotics can not only isolate the contact between the abdominal organs and the outside air, prevent abdominal infection, but also protect the adhesion and even damage of the abdominal organs, especially the intestinal tube. The sponge part of the filling layer, due to the placement of the suction tube, can not only attract and draw out exudate or blood, but also can be sucked by negative pressure to prevent the wound from being too large. The outermost grid-shaped air bag layer can play the role of pressure bandage to stop bleeding after inflation, prevent the injury of the wounded evacuated during wartime from aggravating, and protect and buffer the abdominal organs or intestines.

The invention relates to the technical field of biomedical tissue engineering, and discloses a method for preparing a hydrogel composite biological patch for repairing abdominal wall defects. In the preparation method, pig dermis de-extracellular matrix powder and gelatin are used as biomaterials, and a composite hydrogel biopatch is prepared by mold casting and enzymatic cross-linking forming techniques. The present invention mixes the biomaterial porcine dermis de-extracellular matrix powder with gelatin to prepare the patch, not only the hydrogel patch exhibits excellent biocompatibility, but also enhances the biomechanical properties of the hydrogel patch, solving the problem There are deficiencies with single material patches. At the same time, the preparation process is simple and the required materials are easy to obtain. The composite biological patch scaffold prepared by the present invention contains pre-vascularized channels, which is helpful for the exchange of oxygen and nutrients and the discharge of metabolic waste, and accelerates the vascularization of tissues; in addition, the through-channel structure helps cells and tissues in the scaffold The ingrowth can accelerate the reconstruction of abdominal wall tissue, help to solve the existing technical bottleneck of biological mesh, and effectively improve the therapeutic effect of abdominal wall defect repair.

The present invention provides a method of repairing a defect in an abdominal wall of a subject, including the steps of: making a small incision through a skin layer above the defect in the abdominal wall, introducing a surgical device including a deformable body through the incision to reach a preperitoneum underlying the abdominal wall around the defect, using the surgical device to identify a protruded region of the preperitoneum extending towards the abdominal wall around the defect, and flattening the protruded region of the preperitoneum and separating the protruded region of the preperitoneum from the abdominal wall with the deformable body in an expanded condition. The method results in low recurrence of abdominal wall defect, less pain, and a shorter hospital stay after surgery.

The three-dimensional visualization preoperative planning method, system and terminal for abdominal wall defect reconstruction of the present invention solve the problem that the prior art cannot three-dimensionally display the spatial position relationship between the lesion and the surrounding adjacent blood vessels, tissues, organs, and muscles, and is helpful for doctors to formulate and simulate operations. The solution caused great difficulties, and manual segmentation wasted a lot of time and manpower, which greatly reduced the efficiency and accuracy of cutting operations. The present invention can not only accurately display the location, size, internal structure and relationship with surrounding tissues in the three-dimensional reconstruction image of abdominal wall lesions constructed based on two-dimensional data, but also simulate the expansion of abdominal wall lesions on the premise of avoiding damage to important anatomical structures Abdominal wall defect after resection and the resection of invading tissues and organs, planning the surgical process of patch placement and abdominal wall reconstruction can not only reduce the operation time, but also reduce the incidence of postoperative complications, which has a significant and positive effect on improving the success rate of surgery. effect.

The invention discloses a polyacrylonitrile fiber with biological activity, which is prepared by the following method: after hydrolyzing the polyacrylonitrile fiber in an alkaline solution, it is mixed with a collagen aqueous solution and a cross-linking solution, the pH value is adjusted, and chemical modification is carried out. 2~72h; the raw material of the alkaline solution includes NaHCO 3 , NaOH and water; the raw materials of the cross-linking solution include a cross-linking agent, a buffer substance and water; the collagen-modified polyacrylonitrile fiber contains collagen and polyacrylonitrile. The polyacrylonitrile fiber prepared by the method of the invention maintains the good natural structure of collagen, can better promote the adhesion and proliferation of fibroblasts, is conducive to the directional growth and functional expression of fibroblasts, and has good biocompatibility, The mechanical properties are beneficial to the repair of soft tissue, and are especially suitable for the mechanical strength requirements such as abdominal wall defects.