A kind of absorbable chitin-based composite patch and its application

Abstract

The invention discloses an absorbable chitin-based composite patch and an application thereof. The absorbable chitin-based composite patch is a mesh composed of chitin-based fibers or threads respectively having a surface coating; the chitin-based fibers or threads are insoluble in water, the main chain of the molecular structure of the chitin-based fibers or threads is polyglucosamine and contains an acyl group and a hydrophilic group, the total molar percent content of the acyl group is greater than or equal to 70%, and the total molar percent content of the hydrophilic group is less than 30%; and the surface coating is a water-soluble aminoglycan coating. The absorbable chitin-based composite patch is implanted in an abdominal wall in the operations of abdominal wall defect repairing and hernia repairing, can reduce the inflammatory response in the acute stage, reduce abdominal adhesions, promote the growth of the tissue cells and the synthesis of an extracellular matrix and accelerate the defect repairing of the abdominal walls in the physiologic repairing stage after the operation, and is gradually degraded after the abdominal wall defect repairing, and degradation products are absorbed and utilized by local tissue cells to further promote the abdominal wall defect repairing, so the absorbable chitin-based composite patch has no residual in bodies after being completely degraded, and no foreign matters exist in the bodies.

Description

technical field [0001] The invention relates to a biological patch, in particular to an absorbable chitin-based composite patch and its application, belonging to the field of biomedical materials. Background technique [0002] Hernia is a common disease in general surgery. It is mainly formed by organs or tissues together with the peritoneal wall, which protrudes from the abdominal wall defect or weak point to the body surface, such as inguinal hernia, incisional hernia, stoma hernia, etc., and generally cannot heal by itself. Tension-free hernia repair is the most widely used hernia treatment method in recent years. Open surgery or laparoscopic surgery is used to repair abdominal wall hernia. In the abdominal wall defect, and sutured fixed. Non-degradable synthetic polymer patches such as polypropylene patches and polyester patches commonly used at present are mesh structures woven from synthetic materials such as polypropylene fibers and polyester fibers, and have good te...

AI Technical Summary

Problems solved by technology

However, due to the long-term existence of non-degradable materials such as polypropylene, there are still problems such as sterile inflammation caused by physical stimulation, and at the same time, it does not match the growth and repair of body tissues.

Therefore, research on degradable surgical mesh has received extensive attention, such as biogenic acellular matrix mesh, but biogenic mesh often degrades quickly, has low mechanical strength, and may even produce immunogenic reactions. The degradation time and mechanical The strength does not match the speed of abdominal wall defect and hernia repair, so there is no ideal patch for the treatment of abdominal wall defect

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