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Multilayer composite abdominal wall repair patch support and preparation method thereof

A multi-layer composite, patch technology, applied in the directions of additive manufacturing, manufacturing tools, manufacturing auxiliary devices, etc., can solve the problems of insufficient mechanical properties of fiber scaffolds, and achieve the effects of facilitating proliferation and growth, avoiding infection, and high porosity

Inactive Publication Date: 2019-01-18
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nevertheless, the mechanical properties of the fibrous scaffolds formed by electrohydrodynamic jet printing are not enough to compare with the traditional way of artificially synthesized polymer material patches.

Method used

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  • Multilayer composite abdominal wall repair patch support and preparation method thereof
  • Multilayer composite abdominal wall repair patch support and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] In this example, see figure 1 , a multi-layer composite abdominal wall repair patch bracket, the bracket is a four-layer structure, the bottom of which is a non-porous biological base layer, and two layers of the same three-dimensional structure with a certain pore structure are arranged on the biological base layer The scaffold layer is provided with a synthetic patch intermediate layer between the two three-dimensional structure scaffold layers; the biological base layer prevents the artificial synthetic patch intermediate layer of the scaffold from adhering to the intra-abdominal organs, and the synthetic patch Both the middle layer and the three-dimensional structure support layer have relatively high porosity, and the artificially synthesized patch middle layer is used as the mechanical performance support part of the composite patch support, and the three-dimensional structure support layer is conducive to the adhesion and growth of cells; the biological base layer...

Embodiment 2

[0038] This embodiment is basically the same as Embodiment 1, especially in that:

[0039] In this example, see Figure 1~2 , a method for preparing a multilayer composite abdominal wall repair patch bracket, comprising the steps of:

[0040] a. Weigh 0.4g of acellular dermal matrix (ADM), place it in 5ml of glacial acetic acid solvent, place it on a magnetic stirrer at room temperature and stir until it is completely dissolved to form an acellular dermal matrix solution, namely organic phase A;

[0041] b. This step is identical with embodiment one;

[0042] c. This step is identical with embodiment one;

[0043] d. This step is identical with embodiment one;

[0044] e. Using the electrohydrodynamic jet printing device, directly write a three-dimensional structure scaffold composed of micron fibers on the three-layer scaffold structure obtained in the step d, adjust the voltage to 3.15kV, and the needle tip of the syringe 2 is the same as that in the step c. The dis...

Embodiment 3

[0047] This embodiment is basically the same as the previous embodiment, and the special features are:

[0048] In this example, see Figure 1~2 , a method for preparing a multilayer composite abdominal wall repair patch bracket, comprising the steps of:

[0049] a. Weigh 0.6g of acellular dermal matrix (ADM), place it in 5ml of glacial acetic acid solvent, place it on a magnetic stirrer at room temperature and stir until it is completely dissolved to form an acellular dermal matrix solution, namely organic phase A;

[0050] b. This step is identical with embodiment one;

[0051] c. This step is identical with embodiment one;

[0052] d. This step is identical with embodiment one;

[0053] e. Using the electrohydrodynamic jet printing device, directly write a three-dimensional structure scaffold composed of micron fibers on the three-layer scaffold structure obtained in the step d, adjust the voltage to 3.15kV, and the needle tip of the syringe 2 is the same as that in...

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Abstract

The invention discloses a multilayer composite abdominal wall repair patch support and a preparation method thereof, which are applied to the repair of complex abdominal wall defects. At first, that electrohydrodynamic jet prin method is used to directly write to prepare a porous structure scaffold as a biological base lay; Then, the three-dimensional structure scaffold layer with certain pore structure was fabricated on the biological substrate by electrohydrodynamic jet printing method. After that, the synthetic patch is placed on the three-dimensional structure scaffold layer as the intermediate layer. Finally, the three-dimensional structure scaffold layer which has the same structure as the second layer is fabricated on the three-layer structure which has been fabricated by the electrohydrodynamic jet printing method. Compared with the synthetic patch made of the traditional material, the multi-layer composite abdominal wall repair patch support has good plasticity and suitable porosity. At the same time, on the basis of ensuring that the patch support has original mechanical properties, the invention also has the function of promoting tissue adhesion and growth.

Description

technical field [0001] The invention relates to the technical fields of biological 3D printing and regenerative medicine, in particular to a multilayer composite abdominal wall repair patch bracket and a preparation method thereof, which are mainly used in the field of repairing abdominal wall defects. Background technique [0002] Since American physicians put forward the concept of "tension-free hernia repair surgery" in 1989, mesh has been widely used in abdominal wall defect and hernia repair surgery. In the past ten years, artificial mesh repair technology has also been widely used in surgical operations in my country, and has broad market prospects. [0003] Currently, the material used for the mesh plays an important role in tension-free repair. The materials are mostly artificial polymer materials and biological materials. Most of the patches used in general clinical operations are artificially synthesized polymer material patches, mainly polylactic acid, polypropy...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/36A61L27/18A61L27/58A61L27/56B29C64/118B29C64/393B33Y10/00B33Y50/02
CPCA61L27/18A61L27/3633A61L27/56A61L27/58A61L2300/30A61L2300/404A61L2300/412B29C64/118B29C64/393B33Y10/00B33Y50/02C08L67/04
Inventor 胡庆夕王懿铭张海光李冬冬
Owner SHANGHAI UNIV
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