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Absorbable chitin-based composite patch and application thereof

A chitin and patch technology, used in coatings, medical science, prostheses, etc., can solve the problems of degradation time and mechanical strength and abdominal wall defects, body tissue growth and repair, and hernia repair rates. The effect of promoting the growth of epithelial cells, promoting the growth of fibroblasts, and reducing the occurrence of intraperitoneal adhesions

Active Publication Date: 2017-08-11
青岛健康海洋生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the long-term existence of non-degradable materials such as polypropylene, there are still problems such as sterile inflammation caused by physical stimulation, and at the same time, it does not match the growth and repair of body tissues.
Therefore, research on degradable surgical mesh has received extensive attention, such as biogenic acellular matrix mesh, but biogenic mesh often degrades quickly, has low mechanical strength, and may even produce immunogenic reactions. The degradation time and mechanical The strength does not match the speed of abdominal wall defect and hernia repair, so there is no ideal patch for the treatment of abdominal wall defect

Method used

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  • Absorbable chitin-based composite patch and application thereof
  • Absorbable chitin-based composite patch and application thereof
  • Absorbable chitin-based composite patch and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Water solubility test of chitin-based fibers containing different acylation groups and hydrophilic groups

[0016] Chitin-based fibers with different acylation group content and hydrophilic group content were purchased from Qingdao Shunbo Biotechnology Research Institute. The water solubility of these different chitin-based fibers was tested through experiments. The results are shown in Table 1. It can be seen from Table 1 that when the molar percentage of acyl groups of chitin-based fibers is greater than or equal to 68.5%, and the molar percentage of hydrophilic groups is less than or equal to 30.9%, the chitin-based The fiber does not dissolve in water.

[0017] Table 1. Comparison of water solubility of chitin-based fibers

[0018]

Embodiment 2

[0019] Example 2: Comparison of mechanical strength between chitin-based fiber and chitosan fiber

[0020] Cut 5 lengths of 10cm chitin-based fiber 3 (containing 68.5% of acetyl group) and chitin-based fiber 5 (containing 73.8% of propionyl group and 10.3% of hydroxypropyl group) with a length of 10cm, respectively, and cut 5 lengths It is a 10cm chitosan fiber (purchased from Qingdao Shunbo Biotechnology Research Institute, containing 2.5% acetyl group). The breaking strength of chitin-based fiber and chitosan fiber was tested on an electronic tensile machine. The measurement results show that the average breaking strength of chitin-based fibers 4 is 14.5N, the average breaking strength of chitin-based fibers 5 is 15.2N, and the average breaking strength of chitosan fibers is 10.3N, indicating the breaking strength of chitin-based fibers Higher than the breaking strength of chitosan fiber. Further experiments show that when the molar percentage of hydrophilic groups is less tha...

Embodiment 3

[0022] Example 3: Water-soluble aminoglycans promote cell growth experiment

[0023] Using chondroitin sulfate (purchased from Qingdao Jiulong Biomedical Co., Ltd.), carboxymethyl chitin, and hydroxyethyl chitosan (purchased from Qingdao Honghai Biotechnology Co., Ltd.) as experimental materials, L929 fibroblasts were cultured in vitro and evaluated The effect of three hydrophilic aminoglycans on cell production. The L929 cells in the logarithmic growth phase were trypsinized, and the cell concentration was adjusted to 2.0×10 with DMEM medium 4 Pcs / mL, seeded in 96-well cell culture plate, in CO 2 Incubator (37℃, 5% CO 2 After 24 hours of culture in ), the medium was changed, and the culture wells without water-soluble aminoglycans were used as the control group, and the culture wells containing different concentrations of water-soluble aminoglycans (concentrations of 10, 50, 100, 250, 500 μg / mL) For the experimental group, the cell growth was observed when the cells were culture...

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Abstract

The invention discloses an absorbable chitin-based composite patch and an application thereof. The absorbable chitin-based composite patch is a mesh composed of chitin-based fibers or threads respectively having a surface coating; the chitin-based fibers or threads are insoluble in water, the main chain of the molecular structure of the chitin-based fibers or threads is polyglucosamine and contains an acyl group and a hydrophilic group, the total molar percent content of the acyl group is greater than or equal to 70%, and the total molar percent content of the hydrophilic group is less than 30%; and the surface coating is a water-soluble aminoglycan coating. The absorbable chitin-based composite patch is implanted in an abdominal wall in the operations of abdominal wall defect repairing and hernia repairing, can reduce the inflammatory response in the acute stage, reduce abdominal adhesions, promote the growth of the tissue cells and the synthesis of an extracellular matrix and accelerate the defect repairing of the abdominal walls in the physiologic repairing stage after the operation, and is gradually degraded after the abdominal wall defect repairing, and degradation products are absorbed and utilized by local tissue cells to further promote the abdominal wall defect repairing, so the absorbable chitin-based composite patch has no residual in bodies after being completely degraded, and no foreign matters exist in the bodies.

Description

Technical field [0001] The invention relates to a biological patch, in particular to an absorbable chitin-based composite patch and its application, and belongs to the field of biomedical materials. Background technique [0002] Hernia is a common disease in general surgery. It is mainly formed by organs or tissues together with the peritoneal wall, which is formed by abdominal wall defects or weak points protruding to the body surface, such as inguinal hernia, incisional hernia, stoma hernia, etc., and generally cannot heal itself. Tension-free hernia repair surgery is the most widely used hernia treatment in recent years. Open surgery or laparoscopic surgery is used for abdominal wall hernia repair. The organs protruding from the abdominal wall defect are returned to the abdominal cavity, and then the patch is placed Place the defect on the abdominal wall and suture to fix it. Currently commonly used non-degradable synthetic polymer patches such as polypropylene patch and poly...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/34A61L27/58A61L31/04A61L31/10A61L31/14
CPCA61L27/20A61L27/34A61L27/58A61L31/042A61L31/10A61L31/148A61L2420/02A61L2430/00C08L5/08C08L5/00
Inventor 刘万顺
Owner 青岛健康海洋生物制药有限公司
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