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Net abdominal wall defect repairing material and preparation method thereof

A technology for repairing materials and abdominal walls, applied in medical science, prostheses, etc., to achieve the effects of convenient operation, excellent mechanical properties, and avoiding chronic inflammatory reactions

Active Publication Date: 2013-04-24
HAINAN GUANGYU BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the reduction of polypropylene cannot fundamentally solve the inflammatory response caused by the material itself

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Immerse the sterilized polypropylene mesh into the paraffin solution, take it out later, immerse it in n-hexane for 5min after the paraffin solidifies, and then take it out. The polypropylene mesh with mesh structure has a thickness of 0.4mm and a density of 20g / m 2 , the mesh aperture of the mesh is 10.0mm 2 .

[0018] Acetobacter xylinum, which can secrete bacterial cellulose, was activated to prepare seed mash, and then the seed mash with a strain concentration of 60% was uniformly dropped on the surface of paraffin-treated polypropylene mesh in a dot matrix manner. Add the fermentation medium after adding the seed mash dropwise for 5 minutes. The fermentation temperature was 25°C and the time was 3 days.

[0019] At 50°C, the fermentation product was soaked in distilled water, isopropanol and absolute ethanol for 10 min, respectively. Then heated at 80°C for 6h in a 3% NaOH aqueous solution by weight. Rinse with water repeatedly until neutral. To remove bacter...

Embodiment 2

[0021] Dip the sterilized polypropylene mesh into the paraffin solution, take it out later, and immerse it in n-hexane for 6 minutes after the paraffin solidifies. The polypropylene mesh with mesh structure has a thickness of 0.3mm and a density of 25g / m 2 , the mesh aperture of the mesh is 9.0mm 2 .

[0022] The rhizobia that can secrete bacterial cellulose were activated to prepare seed mash, and then the seed mash with a strain concentration of 95% was uniformly dropped on the surface of a paraffin-treated polypropylene mesh in a dot matrix manner. Add the fermentation medium after adding the seed mash dropwise for 6 minutes. The temperature of the fermentation culture was 26°C, and the time was 2 days.

[0023] At 50°C, the fermentation product was soaked in distilled water, isopropanol and absolute ethanol for 9 minutes respectively. Then heated at 100°C for 6h in 1% by weight NaOH aqueous solution. Rinse with water repeatedly until neutral. To remove bacterial prot...

Embodiment 3

[0025] Dip the sterilized polypropylene mesh into the paraffin solution, take it out later, and immerse it in n-hexane for 7 minutes after the paraffin solidifies. The polypropylene mesh with mesh structure has a thickness of 0.2mm and a density of 30g / m 2 , the mesh diameter of the mesh is 8.0mm 2 .

[0026] The seed mash was prepared by activating Sarcina species that can secrete bacterial cellulose, and then the seed mash with a strain concentration of 80% was uniformly dropped on the surface of a paraffin-treated polypropylene mesh in a dot matrix manner. Add the fermentation medium after adding the seed mash dropwise for 7 minutes. The temperature of the fermentation culture was 28°C, and the time was 3 days.

[0027] At 60°C, the fermentation products were soaked in distilled water, isopropanol and absolute ethanol for 8 min, respectively. Then heated at 60°C for 5h in a 5% NaOH aqueous solution by weight. Rinse with water repeatedly until neutral. To remove bacter...

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Abstract

The invention discloses a net abdominal wall defect repairing material and a preparation method of the net abdominal wall defect repairing material, and relates to the fields of medical instruments and manufacturing techniques of the medical instruments. The net abdominal wall defect repairing material is prepared by dipping a polypropylene mesh which is subjected to sterilization treatment into a wax solution; taking out; after the wax is cured, dipping into n-hexane for 5-10min; selecting bacterial strains which can secrete bacterial cellulose to be activated and prepared into seed mash; subsequently uniformly dropping the seed mash of which the bacterial strain concentration is 60-95% on the surface of the polypropylene mesh subjected to wax treatment; and adding a fermentation medium, culturing for 1-3d and taking out a fermentation product. The fermentation product is subjected to wax elimination and purification treatment so as to obtain the net abdominal wall defect repairing material of the bacterial cellulose composite polypropylene mesh. The net abdominal wall defect repairing material is simple in process and convenient to operate; and the prepared net abdominal wall defect repairing material has excellent mechanical properties and after being implanted into a body, the net structure is beneficial for fiber textures to grow and penetrate through, thereby preventing chronic inflammatory response and adhesion inside abdominal walls.

Description

technical field [0001] The invention relates to the technical field of medical equipment and its preparation, in particular to a mesh-shaped abdominal wall defect repair material and a preparation method thereof. Background technique [0002] Abdominal wall defect is the rupture or weakening of the abdominal wall supporting the viscera in a certain part, so that the abdominal viscera and peritoneum protrude to the body surface through the weak part or hole of the abdominal wall to form a local mass. This kind of abdominal wall defect may occur in various ages. There are some weak areas on the abdominal wall of normal people, such as the inguinal canal and the femoral ring; in addition, some people have defects in the development of certain parts of the abdominal wall, such as incomplete umbilical ring and abdominal white line. Abdominal wall damage caused by surgical incisions and trauma; abdominal wall muscle weakness caused by senile muscle atrophy can all cause abdominal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/20A61L27/16
Inventor 钟春燕其他发明人请求不公开姓名
Owner HAINAN GUANGYU BIOTECH
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