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A bionic antibacterial abdominal wall repair material

A technology for repairing material and abdominal wall, applied in the field of bionic antibacterial abdominal wall repair material, can solve the problems of prolonging treatment time, health economy, social labor loss, etc., and achieves the effect of solving technical bottleneck, improving treatment effect, and promoting angiogenesis.

Active Publication Date: 2020-11-24
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Abdominal wall defects caused by pollution and infection are very common in the cases of war trauma, traffic injuries, and simultaneous bowel operations. At present, most of these abdominal wall defects are debridement in the first stage, followed by definitive abdominal wall repair with materials in the second stage. It not only prolongs the treatment time, causes long-term pain to the patient, but also causes the loss of health economy and social labor force.

Method used

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  • A bionic antibacterial abdominal wall repair material
  • A bionic antibacterial abdominal wall repair material
  • A bionic antibacterial abdominal wall repair material

Examples

Experimental program
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Effect test

Embodiment 1

[0020] A bionic antibacterial abdominal wall repair material, such as figure 1 As shown, a chitosan-elastic protein fiber web layer of the lower layer of the pig small intestinal mucosa and a film of the film is in the lower layer of the porcine mucosa.

[0021] The above chitosan-elastic protein fiber web layer has a thickness of 50 microns and a nano-clad chitosan-elastin fiber having a fiber diameter of 100 nanometers, and the nanometer chitosan-elastic protein fiber is prepared by electrostatic spinning. Received. like figure 2 and image 3 The lower layer of the lower layer of piglets is 4 layers of deparagmous porcine mucosa underlayer.

[0022] like Figure 4 and Figure 5 As shown, the scanning electron microscopy of the resulting bionic antibacterial abdominal wall repair material is prepared. Figure 4 The chitosan-elastic protein fiber surface in the abdominal wall repair material is smooth, and the fiber diameter is nanometer level; Figure 5 The two layers of materials in ...

Embodiment 2

[0024] A bionic antibacterial abdominal wall repair material, comprising a porcine small intestinal mucosa under a chitosan-elastic protein fiber web layer on one side of the lower layer of a small colorectal mucosa

[0025] In the present embodiment, the thickness of the nano-casform-elastic protein fiber web layer is 100 microns, the nano-stage chitosan-elastin fiber has a fiber diameter of 150 nm, and the nanoscale chitosan-elastin fiber web It is obtained by preparing electrostatic spinning. The lower layer of the porcine in the present embodiment is a 4-layer deparagrantal porcine mucosa underlayer.

Embodiment 3

[0027] A bionic antibacterial abdominal retaining material comprising a porcine small intestinal mucosa under a nanoscale chitosan-elastin fiber web layer on the side of the lower layer of piglets.

[0028] In the present embodiment, the nanoside chitosan-elastic protein fiber web layer has a thickness of 150 microns, and the fiber diameter of nano-casing chitosan-elastin fibers is 200 nm, and the nano-casing chitosan-elastic protein fiber web is It is obtained by preparing electrostatic spinning. The lower layer of the porcine in the present embodiment is a 4-layer deparagrantal porcine mucosa underlayer.

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Abstract

The invention discloses a bionic antimicrobial abdominal wall repair material. The bionic antimicrobial abdominal wall repair material includes a pig small intestine submucosa and a chitosan-elastin fiber mesh layer laminating on one side of the pig small intestine submucosa; and the chitosan-elastin fiber mesh layer is an electrostatic spinning nanoscale chitosan- elastin fiber mesh. According tothe bionic antimicrobial abdominal wall repair material, the laminating combination of the chitosan-elastin fiber mesh layer and the pig small intestine submucosa, so that the antimicrobial ability of the prepared abdominal wall repair material is improved effectively; meanwhile, the mechanical strength and degradation performance of the abdominal wall repair material meet the requirement of abdominal wall repair, angiogenesis can further be facilitated, tissue regeneration is facilitated, the existing technical bottleneck of the abdominal wall repair material is solved conveniently, and thetreatment effect of abdominal wall coloboma repair is effectively improved.

Description

Technical field [0001] The present invention belongs to the technical field of medical consumables, and in particular to a bionic antibacterial abdominal wall repair material. Background technique [0002] The development and application of abdominal wall repair materials is an important direction for current hernia and abdominal surgery research. The current abdominal wall repair patch still has some problems that need to be solved. Their main disadvantages are still low in biological activity, resulting in uneven cellularization of vascularization and implant itself, eventually leading to lack of integration and tissue regeneration with surrounding tissues. Recent abdominal wall repair uses a deparagor substrate representing the development of a development of bionic transplants, which is characterized by higher biocompatibility and improved in vivo performance. After implantation, the graft experiences one of the following destiny: (i) new blood vessel formation and new ECM de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/36A61L27/20A61L27/22A61L27/54
CPCA61L27/20A61L27/227A61L27/3629A61L27/54A61L2300/252A61L2300/404A61L2300/606C08L89/00C08L5/08
Inventor 李晓明曹广秀牛旭锋樊瑜波
Owner BEIHANG UNIV
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