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Abdominal wall defect repair material and preparation method thereof

A technology for repairing materials and abdominal walls, applied in medical science, prostheses, etc., can solve problems affecting mechanical properties and achieve the effects of convenient operation, avoiding chronic inflammatory reactions, and excellent mechanical properties

Active Publication Date: 2013-04-17
钟春燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the reduction of the amount of polypropylene material will inevitably affect its mechanical properties; at the same time, the reduction of polypropylene cannot fundamentally solve the inflammatory response caused by the material itself

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Acetobacter xylinum, which can secrete bacterial cellulose, was activated to prepare seed mash, and then the seed mash with a strain concentration of 60% was evenly added dropwise on the surface of sterile polypropylene mesh that had been autoclaved. The polypropylene mesh with mesh structure has a thickness of 0.2mm and a density of 70g / m 2 , the mesh diameter of the mesh is 3.0mm 2 . Add the fermentation medium after adding the seed mash dropwise for 5 minutes. The fermentation temperature was 25°C and the time was 1d. During the fermentation period, the polypropylene mesh was turned over every 12 hours.

[0018] The fermentation product was heated at 80°C for 6 hours in a 3% NaOH aqueous solution by mass percentage. Rinse with water repeatedly until neutral. To remove bacterial protein and residual medium adhering to the cellulose membrane. Obtain the composite membrane of bacterial cellulose and polypropylene net sheet that thickness is 0.22mm, wherein polypro...

Embodiment 2

[0021] The rhizobia that can secrete bacterial cellulose were activated to prepare seed mash, and then the seed mash with a strain concentration of 95% was uniformly dropped on the surface of sterile polypropylene mesh that had been sterilized by autoclaving in a dot matrix manner. The polypropylene mesh with mesh structure has a thickness of 0.2mm and a density of 60g / m 2 , the mesh diameter of the mesh is 4.0mm 2 . Add the fermentation medium after adding the seed mash dropwise for 6 minutes. The temperature of the fermentation culture was 26°C, and the time was 2 days. During the fermentation period, the polypropylene mesh was turned over every 24 h.

[0022] The fermentation product was heated at 100°C for 6 hours in a 1% NaOH aqueous solution by mass percentage. Rinse with water repeatedly until neutral. To remove bacterial protein and residual medium adhering to the cellulose membrane. Obtain the composite membrane of bacterial cellulose and polypropylene net sheet...

Embodiment 3

[0025] The sarcinina species that can secrete bacterial cellulose were activated to prepare seed mash, and then the seed mash with a strain concentration of 80% was evenly added dropwise on the sterile polypropylene mesh that had been sterilized by irradiation surface. The polypropylene mesh with mesh structure has a thickness of 0.05mm and a density of 90g / m 2 , the mesh diameter of the mesh is 0.2mm 2 . Add the fermentation medium after adding the seed mash dropwise for 7 minutes. The temperature of the fermentation culture was 28°C, and the time was 3 days. During the fermentation period, the polypropylene mesh was turned over every 36 h.

[0026] The fermentation product was heated at 60°C for 5 hours in a 5% NaOH aqueous solution by mass percentage. Rinse with water repeatedly until neutral. To remove bacterial protein and residual medium adhering to the cellulose membrane. Obtain the composite membrane of bacterial cellulose and polypropylene net sheet that thickn...

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Abstract

The invention discloses an abdominal wall defect repair material and a preparation method thereof, and relates to the technical field of a medical device and the preparation thereof. The method comprises the steps of selecting bacterial strains capable of secreting bacterial cellulose, performing activation, preparing a seed mash, dropwise adding the seed mash with a strain concentration ranging from 60% to 95% evenly on a sterilized polypropylene mesh, adding an afermentation medium, and taking out fermentation products after 1-3 d of culture. The abdominal wall defect repair material of the bacterial cellulose composite polypropylene mesh is obtained after the fermentation products are purified. According to the abdominal wall defect repair material and the preparation method thereof, the process is simple, the operation is convenient, and the prepared abdominal wall defect repair material has good mechanical properties and can avoid reaction of chronic inflammation and adhesion with an abdominal wall after transplanted into a body.

Description

technical field [0001] The invention relates to the technical field of medical equipment and its preparation, in particular to a preparation method of bacterial cellulose abdominal wall defect repair material. Background technique [0002] Abdominal wall defect is the rupture or weakening of the abdominal wall supporting the viscera in a certain part, so that the abdominal viscera and peritoneum protrude to the body surface through the weak part or hole of the abdominal wall to form a local mass. This kind of abdominal wall defect may occur in various ages. There are some weak areas on the abdominal wall of normal people, such as the inguinal canal and the femoral ring; in addition, some people have defects in the development of certain parts of the abdominal wall, such as incomplete umbilical ring and abdominal white line. Abdominal wall damage caused by surgical incisions and trauma; abdominal wall muscle weakness caused by senile muscle atrophy can all cause abdominal wal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/16
Inventor 钟春燕其他发明人请求不公开姓名
Owner 钟春燕
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