51 results about "17beta estradiol" patented technology

The invention relates to the technology for detecting trace estrogens in sludge, in particular to a method for detecting trace oestrone and 17beta-estradiol content in a sludge sample. The method comprises the following steps of: performing freeze drying on the collected sludge sample, adding NaN3, performing oscillation extraction by adopting acetone, performing quick solvent extraction, and merging the extract liquor; and concentrating and enriching estrogens in the extract liquor by adopting a solid phase extraction column, washing the estrogens off from the solid phase extraction column by adopting ethyl acetate, and analyzing the estrogen concentration by utilizing liquid chromatography tandem mass spectrometry. The method has the advantages of environmental protection, easy operation and high recovery rate, and can quickly analyze the trace oestrone and 17beta-estradiol content in the sludge sample.

The invention relates to a detecting technique of endocrine disrupters in water environment and particularly relates to a technique for quantitative analysis on oestrone, 17beta-estradiol, estriol, 17alpha-ethinyl estradiol, nonyl phenol, octylphenol and bisphenol A in a complex substrate water sample by adopting a liquid chromatogram-tandem mass spectrum combined technique. The method comprises the following steps: enriching a collected water sample by using a HLB (Hydrophile-Lipophile Balance) solid-phase extraction column and washing with carbinol; drying elution liquid nitrogen and purifying by using Florisil; and finally, analyzing by utilizing the liquid chromatogram-tandem mass spectrum combined technique. The method is environment-friendly, easy to operate and high in recovery rate. The method can quickly analyze the trace amount of oestrone, 17beta-estradiol, estriol, 17alpha-ethinyl estradiol, nonyl phenol, octylphenol and bisphenol A in the complex substrate water sample.

The present invention discloses a 17beta-estradiol visualization detection method based on DNA nano-structure, and a 17beta-estradiol visualization detection kit based on DNA nano-structure. The working principle is that 17b-estradiol interacts with aptamer, a strand displacement reaction is started, three groups of stem-loop DNA probes are constantly opened to form DNA nano-structures, a G tetramer having catalysis activity is formed on the terminals of the three DNA arms in the DNA nano-structures, the G tetramer is bound with hemin so as to form a compound having catalysis activity and similar to HRP, TMB is subjected to catalytic oxidation, and a blue substrate is produced, wherein the result is visible, and the concentration of 17b-estradiol is directly related to the blue shade. According to the present invention, the operation is simple, the whole reaction can be completed at the room temperature, the high sensitivity is provided, the detection limit on 17b-estradiol is 100 fM, the good specificity is provided, the detection result is directly visible without any detection equipment, and the method and the kit can be used for the on-site rapid detection of 17b-estradiol.

The invention relates to a method for preparing a photoelectric adapter sensor for detecting 17beta-estradiol. The photoelectric adapter sensor takes a prepared cadmium selenide nano particle modified titanium dioxide nano tube as a matrix electrode; after the surface of the electrode is functionalized by chitosan and glutaraldehyde, and a 17beta-estradiol adapter is dropwise added onto the surface of the electrode so as to prepare the 17beta-estradiol photoelectric adapter sensor. Compared with the prior art, the method combines the 17beta-estradiol photoelectric adapter sensor with specific recognition capability with a supersensitive photoelectric analysis technique for detecting an environmental internal-secretion interfering-substance 17beta-estradiol, so that not only is high sensitivity acquired, but also interference of a complex matrix environment is prevented, and high selectivity is achieved; when the method is used in low-concentration 17beta-estradiol detection, a wide working curve range of 5*10<-13> mol / L to 15*10<-12> mol / L is obtained, the minimum detection limit can be 3.3*10<-14> mol / L, and moreover, the 17beta-estradiol photoelectric adapter sensor is simple in preparation method, low in cost and good in stability and repeatability.

A hormone replacement therapy, comprising a plurality of daily doses of a pharmaceutical preparation, the doses being administered continuously and consecutively in alternating phases of three daily doses, a relatively dominant estrogenic activity phase comprising three daily doses of a substance exhibiting estrogenic activity equivalent to about 1 mg per day of 17beta-estradiol per day, and a relatively dominant progestagenic activity phase of a combination of a substance exhibiting estrogenic activity equivalent to about 1 mg per day of 17beta-estradiol and a substance exhibiting progestogenic activity equivalent to about 90 mug per day of norgestimate.

The invention discloses a derivatization method of environmental estrogens (estrone, 17beta-estradiol, estriol, 17alpha-ethynylestradiol), which is a treatment method and a core technology before a gas chromatography-mass spectrum (GC-MS) is used for analyzing the samples of the substances. The method comprises the following steps: firstly, leading high-purity nitrogen in at a room temperature to dry a standard mixed solution containing environmental estrogens; adding derivative reagents N, O-BSTFA and pyridine to react at room temperature (20 DEG C)-50 DEG C to obtain derivative products; drying; adding a sampling solvent and an internal standard; sampling and analyzing. The method has the advantages of simple and convenient experimental operation, time saving and low energy consumption and cost, simultaneously derivates the four environmental estrogens without generating side products, has favorable linear correlation among various derivative products and achieves an instrument detection limit up to 0.5pg / muL, thereby being applied to the GC-MS detection of environmental estrogens in water bodies, sediment, biological samples, and the like.

The present invention relates to the preparation method and the application of a 17 beta-estradiol molecularly-imprinted polymer, which belongs to the analysis and measurement technology field of the 17 beta-estradiol of the biological samples and food samples. The present invention proposes a method for the preparation of 17 beta-estradiol molecularly-imprinted polymer as well as the separation, purifying and examination method of the 17 beta-estradiol molecularly-imprinted polymer in the biological samples and food samples. The 17 beta-estradiol molecularly-imprinted polymer generated by the present invention is of selective absorption. The present invention can separate, purify, concentrate and fast examine and analyze the 17 beta-estradiol molecularly-imprinted polymers in the environmental, biological samples and food samples.

The invention belongs to the technical field of food safety testing immunoassay and relates to a bisphenol A and 17beta-estradiol detection kit based on an upconversion fluorescence aptamer sensor, anapplication and a detection method. The kit comprises (1) first carboxylated core / shell upconversion nanoparticles NaYF4:Yb,Er@NaYF4:Nd, (2) second carboxylated core / shell upconversion nanoparticlesNaYF4:Yb,Tm@NaYF4:Nd, (3) a target aptamer sequence and a regular tetrahedron structure composition sequence designed according to a complementary strand of the aptamer as well as (4) a black phosphorus nanogold composite dispersion, wherein targets comprise bisphenol A and 17beta-estradiol; the regular tetrahedron structure composition sequence comprises a complementary strand sequence of the aptamer sequence, and the at least part of the complementary strand sequence forms the regular tetrahedron structure sequence. With adoption of the kit or the detection method, bisphenol A and / or 17beta-estradiol can be detected with high sensitivity.

The invention relates to preparation and application of manganese dioxide modified charcoal for removing 17beta-estradiol in water. The charcoal is mainly prepared from forestry and agricultural residues, and the preparation raw material is wide in source and low in price. The charcoal is prepared through the specific steps that biomass dried and ground into powder is subjected to high temperature calcination; after charcoal is prepared, the surface of the charcoal is loaded with manganese dioxide nano particles through an improved Murray synthesis method. The manganese dioxide modified charcoal prepared through the method has high removal capacity to 17beta-estradiol in the water. The manganese dioxide modified charcoal is easy to prepare and low in price, and is a cheap and efficient adsorbent. The adsorption capacity of the charcoal is remarkably improved through modification of manganese dioxide, and high application potential is achieved.

The invention relates to an electrochemical analyzing method for constructing a 17beta-estradiol aptamer sensor based on a dendritic gold modification boron-mixed diamond film BDD electrode and provides an electrochemical analyzing method high in sensitivity and high in selectiveness. The method comprises the steps of manufacturing special-morphology nanometer dendritic gold / BBD electrodes based on an electrochemistry method and further performing nucleic acid aptamer load assembly by adopting the surface characteristics of the modified electrode to construct the 17beta-estradiol aptamer sensor, wherein the sensor is used for detecting environmental internal-secretion interfering-substance, namely, 17beta-estradiol. Compared with the prior art, a dendritic gold structure with multiple levels of active sites is constructed on the BDD substrate electrode with a simple and novel double-template method, a nucleic acid aptamer capable of being combined with target substances in a peculiar mode is adopted at the same time, noise in the analyzing process is effectively lowered, the detection sensitivity and selectiveness of the sensor are greatly improved, the detection limit reaches 5*10<-15> mol / L, and the sensor has good reproducibility.

The invention discloses a method for detecting 17beta-estradiol by employing a colorimetric method based on a nucleic acid aptamer. The method comprises the following steps: drawing a standard curve, namely preparing a 17beta-estradiol standard system, recording absorbance values of a standard solution and a contrast solution under the conditions of wavelengths of 650nm and 520nm, plotting by virtue of the specific value difference Delta A between the relative absorbance corresponding to the standard solution and the contrast solution, and drawing a standard curve; detecting a 17beta-estradiol sample, namely adding a to-be-detected sample to a buffer solution containing the nucleic acid aptamer, mixing evenly, incubating and simultaneously adding water to obtain the contrast solution; adding a cationic polymer solution, mixing evenly and incubating; adding a nano gold solution, mixing evenly and incubating; and calculating the 17beta-estradiol content in the to-be-tested sample, namely determining the concentration of the 17beta-estradiol in the to-be-tested sample according to the standard curve corresponding to the difference value Delta A between A650 / A520 measured by the sample and the A650 / A520 of a blank control group.

The invention provides a 17beta-estradiol molecular imprinted silver-doped TiO2 nanotube and a preparation method thereof. The material can selectively adsorb 17beta-estradiol and degrade 17beta-estradiol and is doped with silver to powerfully kill certain pathogenic microorganisms. The TiO2 nanotube comprises a TiO2 nanotube with two open ends, a molecular imprinting polymer and Ag simple substance, which are formulated in a mass ratio of 58:33:9, wherein the molecular imprinting polymer contains methacrylic acid, trimethylolpropane trimethylacrylate and azo-biscyanopentanoic acid, which are formulated in a mole ratio of 124:123:1, and the molecular imprinting polymer is loaded with carbonyl functional groups; the TiO2 nanotube is 90 nm in diameter, 600 nm in length, 0.51 cm3 / g in porosity and 290 m2 / g in specific surface area ; and the mole ratio of functional monomer methacrylic acid to template molecule 17beta-estradiol is 124:26. The 17beta-estradiol molecular imprinted silver-doped TiO2 nanotube has a good 17beta-estradiol adsorbing effect, can degrade 17beta-estradiol with high degradation rate up to 98%, can powerfully kill certain pathogenic microorganisms, and is significant in improving the quality of reclaimed water from sewage.

The invention relates to a pseudomonas citronelloalis strain and application thereof in degrading estrogen, wherein the pseudomonas citronelloalis strain has the preservation number of CGMCC No.3634, can grow by using natural or synthetic estrogen as a unique carbon source, can efficiently degrade theelin (E1), 17beta-estradiol (E2) and 17alpha-ethinyl estradiol (EE2) and can be used for a micro-biological degradation technology for removing the estrogen. Under the culture condition of using the estrogen as the unique carbon source, the theelin and the 17beta-estradiol with the initial concentration of 2mg / L can be respectively degraded by 99 percent by the SS-2 strain within 36 hours, the 17alpha-ethinyl estradiol with the initial concentration of 4mg / L can be degraded by 93.6 percent within 168 hours, and estriol has no remarkable degradation phenomenon. The theelin is generated in the process of degrading the 17beta-estradiol, and the theelin is also gradually degraded. Because the pseudomonas citronellolis SS-2 strain has the characteristics of effectively degrading the natural and synthetic estrogen in an environment, the pseudomonas citronellolis SS-2 strain can be applied to an estrogen-contained waste sewage treatment technology or a soil remediation technology.

The invention discloses preparation of a clay mineral modified biochar material and application of the clay mineral modified biochar material in removing estrogen, namely 17beta-estradiol, pollutants. The clay mineral modified biochar material is prepared from the following biochar raw materials of agricultural and forestry residues, straws, rice hulls, peanut hulls, sugarcane bagasse, wood shavings and the like. The preparation comprises the specific steps: activating a biomass and attapulgite for 24 hours by utilizing zinc chloride, roasting the mixture under 600 DEG C for 1.5 hours after drying, and washing and drying, thus obtaining the attapulgite modified biochar. The attapulgite modified biochar prepared by a method disclosed by the invention has a large amount of adsorption sites. Research on influence of the initial concentration, the pH (Potential of Hydrogen) and the time on adsorption of the 17beta-estradiol in a water body discovers that an attapulgite modified biochar material has stronger adsorption ability on the 17beta-estradiol; the attapulgite modified biochar material is simple in preparation, low in cost and excellent in adsorption performance, and is an adsorbent which is higher in application potential.

The invention relates to an oat acidovorax avenae strain capable of biodegrading natural estrogen and the application thereof, and the preservation code is CGMCC No. 3633; natural estrogen serves as the only one carbon source and is grown, can degrade estrone, 17Beta-estradiol and estriol with high efficiency, and can be used for a microbial technology for removing estrogen. The SS-1 strain can degrade the estrone with the initial concentration of 1mg / L by 99 percent within 12h, and degrade the 17Beta-estradiol and estriol with the initial concentration of 1mg / L by 99 percent within 24h. Estrone is generated in the degradation process of 17Beta-estradiol, and the estrone is also gradually degraded. Because the acidovorax avenae SS-1 strain has the property of effectively degrading the natural estrogen in the environment, and thereby can be applied in a technology for controlling wastewater and sewage which contain estrogen or a soil restoration technology.

The invention relates to a method for rapidly detecting steroid hormones in urea through an UPLC-MS / MS technology, and belongs to the field of analysis chemistry and medical science. The concentrations of estriol, hydrocortisone, 17beta-estradiol, testosterone and progesterone in human urea are simultaneously detected through the UPLC-MS / MS technology by adopting a beta-glucuronidase enzymatic hydrolysis technology, the detection limit is 0.1-1.0 ng / mL, and the quantitation limit is 0.3-3.0 ng / mL. The method is fast, sensitive and accurate, can meet requirement of simultaneous detection of above five steroid hormones in urea, and has wide application prospect.

A hormone replacement therapy, comprising a plurality of daily doses of a pharmaceutical preparation, the doses being administered continuously and consecutively in alternating phases of three daily doses, a relatively dominant estrogenic activity phase comprising three daily doses of a substance exhibiting estrogenic activity equivalent to about 1 mg per day of 17beta-estradiol per day, and a relatively dominant progestagenic activity phase of a combination of a substance exhibiting estrogenic activity equivalent to about 1 mg per day of 17beta-estradiol and a substance exhibiting progestogenic activity equivalent to about 90 mug per day of norgestimate.

The invention provides an isonicotinamide eutectic crystal of 17beta estradiol, and a preparation method and application thereof. Particularly, the invention provides the isonicotinamide eutectic crystal of 17beta estradiol. X-ray powder diffraction analysis, thermogravimetic analysis, differential scanning thermometric analysis and other analysis indicate that the eutectic crystal provided by the invention has more excellent physicochemical property and pharmaceutical property. The invention provides the preparation method of the eutectic crystal. The method is simple to operate, easy to control and favorable in reproducibility, and can stably obtain the target eutectic crystal.

The invention relates to a composite bacterium capable of quickly degrading 17Beta-estradiol. The composite bacterium can be used to quickly degrade steroid estrogen-17Beta-estradiol in livestock breeding waste, reducing environmental pollution and resourcefully using livestock excrement. The composite bacterium that can quickly degrade 17Beta-estradiol is composed of Acinetobacter calcoaceticus LM1 collected under CGMCC No. 10814 and Pseudomonas LY1 collected under CGMCC No. 10815. Mass experiments prove that Acinetobacter calcoaceticus LM1 and Pseudomonas LY1 are mixed according to a cell ratio of 1:1, giving optimal degrading efficiency for treating livestock breeding waste and 17Beta-estradiol in soil.

The invention provides a method for preparing a 17beta-estradiol molecularly imprinted polymer by adopting a mixed template, comprising the steps of taking a mixture of 17beta-estradiol and 17alpha-estradiol as template molecules, selecting and using methacrylic acid or methyl methacrylate as functional monomers, subjecting to ultrasonic processing after mixing with a pore-forming agent, adding a cross-linking agent, standing for 1h, adding an initiator, introducing nitrogen to seal, carrying out bulk polymerization in a container by adopting a thermal initiation way, grinding and sieving the polymer, eluting the template molecule by using a Soxhlet extraction method, drying in vacuum and obtaining the 17beta-estradiol molecularly imprinted polymer. The method has the advantages that 17beta-estradiol can be high-efficiently gathered, therefore, the detection time can be shortened, the detection cost is reduced, and the method has wide application prospects.

The invention relates to a preparation method and application of a CTAB (cetyl trimethyl ammonium bromide) surface-activated clay mineral-loaded nano-iron manganese oxide adsorbent for removing an emerging organic pollutant 17beta-estradiol in water. Surface treatment is carried out on attapulgite clay mineral by using CTAB, iron and manganese oxides are loaded on the surface, adsorption sites of the material are added, so that the adsorptive property of attapulgite on the pollutant in the water is strengthened. The preparation method comprises the following specific steps of carrying out pretreatment on the attapulgite by using a hydrochloric acid and sodium chloride, carrying out surface activation on the attapulgite by using the CTAB and loading the iron and manganese oxides to the surface to increase the adsorption sites. The CTAB surface-activated clay mineral-loaded nano-iron manganese oxide adsorbent prepared by the method has relatively high removal capacity on the 17beta-estradiol in the water and is high in adsorption rate, and the 17beta-estradiol in the water can be quickly treated. The material is low in cost, simple and feasible, massive production can be realized, and the product is nontoxic and harmless and is an organic matter adsorption material with a relatively good application prospect.

The invention relates to a hydrothermal carbon modified material capable of removing an environmental estrogen pollutant 17beta-estradiol, in particular to a hydrothermal carbon / attapulgite / beta-FeOOH composite material. A preparation method of the material comprises the following steps: performing hydrothermal carbonization on attapulgite and biomass; assembling the attapulgite on the surface of hydrothermal carbon; activating with KOH; loading beta-FeOOH onto the surface of the material; increasing the specific surface area to prepare a high-performance hydrothermal carbon / attapulgite / beta-FeOOH composite adsorption material. The modified hydrothermal carbon material prepared by the method has a large quantity of adsorption sites, and can be used for efficiently removing the environmental estrogen 17beta-estradiol. Moreover, the hydrothermal carbon modified material is easy to prepare, is low in cost, has high adsorption performance, and is an adsorbent with a wide market prospect.

The invention discloses a 17 beta-estradiol colorimetric detecting method based on nanogold collected by a surfactant. The method comprises the following steps: adding a 17 beta-estradiol sample to be detected into an aptamer solution, uniformly mixing and incubating to obtain a mixed solution A; adding the surfactant and a buffer solution into the mixed solution A, uniformly mixing and incubating to obtain a mixed solution B; adding a nanogold solution into the mixed solution B and mixing to obtain a solution C; determining that the light absorption value ratio A650 / 520 of a blank control solution and the solution C at the positions of 650 nm and 520 nm are respectively A0 and A, and obtaining delta A according to the formula that delta A=A-A0; determining the content of 17beta-estradiol corresponding to delta A according to a standard curve of the content of 17beta-estradiol. The provided detecting method is quick, cheap, high in sensitivity and good in selectivity, the minimum detection limit is 1.96 nmol / L, and the defects of consuming time, relying on large-scale instruments and equipment, being high in cost, and the like, in the conventional detecting method are overcome.

A pharmaceutical dosage unit for oral administration to a human female comprising a therapeutically effective amount of 17beta-estradiol-3-lower alkanoate, most preferably 17beta-estradiol-3-acetate, and a pharmaceutically acceptable carrier is disclosed. Also disclosed is a method for treating a human female in need of 17beta-estradiol and a contraceptive method by oral administration of the pharmaceutical dosage unit and a method of preparing a pharmaceutical composition that may be used to form the pharmaceutical dosage unit of the invention.

The invention belongs to the technical field of assay and test and relates to a technology for rapid screening of estrogenic active compounds. The basic principle is to arrange test compounds, immobilized 17beta estradiol and estrogen receptor proteins ERalpha-LBD or ERbeta-LBD in the same reaction system to lead the test compounds and the immobilized 17beta estradiol to be competitively bound with the ERalpha-LBD or the ERbeta-LBD, and the number of the estrogen receptor proteins which are combined on the immobilized 17beta estradiol is finally detected by the enzyme-linked reaction. The basic evaluation basis of the estrogenic activity is to contrast the competitive binding capacities of the test compounds and the 17beta estradiol to the estrogen receptor proteins ERalpha-LBD or the ERbeta-LBD, thereby evaluating the estrogenic activity of the test compounds. The technology has wide application prospects in the aspects of toxicological studies of environmental pollutants, studies of metabolites of compounds, toxicity evaluation of industrial products, drug screening, analysis of active ingredients, etc.

The invention relates to a method for representing a 17beta-estradiol (E2) soil column leaching process, and belongs to the field of environmental science and environmental engineering subject. The method includes steps of 1), filling soil samples into a soil column apparatus uniformly, leaching after uniformly adding E2 standard samples on the surface layer of a soil column, and measuring concentrations of E2 and E1 in leachate and calculating accumulative leaching quantity; 2), setting size and boundary of cell sets and initializing cell status; 3), making an evolution rule according to a micromechanism; 4) calculating parameters required for a model; and 5), performing iterative calculation. By the method, advantages of flexibility and diversity of a CA (cellular automata) model are utilized, and the CA model capable of simulating the E2 soil column leaching process is established according to the micromechanism that the E2 is subjected to adsorption, desorption, degradation and migration in the soil column leaching process, so that dynamically visual representation of the E2 in the soil column leaching process is achieved.

The invention relates to a zebra fish vitellogenin immunoblotting reagent kit as well as a detection method and application thereof. The reagent kit contains a zebra fish vitellogenin pure product and a rabbit anti-zebra fish vitellogenin polyclonal antibody. The preparation method comprises the steps: producing vitellogenin by inducing the zebra fish by utilizing 17beta-estradiol, purifying the vitellogenin by virtue of a method combining the two-step chromatography and hyperfiltration, then immunizing a New Zeeland rabbit to prepare the rabbit anti-zebra fish vitellogenin polyclonal antiserum, precipitating by utilizing ammonium sulfate and carrying out chromatographic purifying by utilizing Hitrap Protein G to obtain the rabbit anti-zebra fish vitellogenin polygonal antibody. The reagent kit can be used for screening environmental estrogen substances and sensitively and conveniently qualitatively detecting the vitellogenin in zebra fish blood, integral homogenate, liver tissues and liver cell culture liquid, the minimum detection limit is 60ng / mL, and an important tool can be provided for the application of the zebra fish in the endocrine disrupter detection field.

The invention discloses a 17beta-estradiol / PLGA sustained release microsphere and a preparation method thereof. The preparation method is simple, the sustained release microsphere prepared by the method is pore-free, smooth and round in surface, uniform in sphere size, full in shape and uniform in microsphere distribution, obvious adhesion is avoided, earlier initial burst release or terminal stage rapid release can be well avoided, the 17beta-estradiol can be slowly released, and the drug loading capacity and encapsulation efficiency are high.

The invention discloses a preparation method of [3-14C] labeled steroid estrogen and belongs to the field of compounds labeled by a radio isotope 14C. According to the preparation method, 14C radio isotope labeling is introduced into the structure of estrogen, the 14C labeling site is a C-3 site in a loop A, and the general structural formula is shown by a figure 1. The preparation method comprises the following steps: by taking nandrolone as an initiator, performing acetyl (or benzoyl) protection, ozone oxidation ring opening and inner ester condensation to generate olefin alcohol inner ester; then performing condensation reaction on the olefin alcohol inner ester and 14C labeled acetyl chloride CH314COCl at -78 DEG C, and hydrolyzing the obtained 14C labeled olefin alcohol type transition state product under an acidic condition to generate 14C labeled acetyl nandrolone (or benzoyl nandrolone) at the 3rd site of the loop A of steroid; and aromatizing and hydrolyzing the 14C labeled acetyl nandrolone (or benzoyl nandrolone) to obtain [3-14C]-17beta-estradiol ([3-14C]-17beta-E2). The [3-14C]-17beta-E2 is oxidized by a Jones reagent to generate [3-14C]-estrone ([3-14C]-E1).

A pharmaceutical dosage unit for oral administration to a human female comprising a therapeutically effective amount of 17β-estradiol-3-lower alkanoate, most preferably 17β-estradiol-3-acetate, and a pharmaceutically acceptable carrier is disclosed. Also disclosed is a method for treating a human female in need of 17β-estradiol and a contraceptive method by oral administration of the pharmaceutical dosage unit and a method of preparing a pharmaceutical composition that may be used to form the pharmaceutical dosage unit of the invention.