34results about How to "Successful application" patented technology

Many business problems involve too many complex and interacting variables for a person to solve them, unassisted. Linear programming, statistical and probability analyses provide effective tools for solving such problems, but until now, use of these tools has not been practical for persons without extensive mathematical training. The present invention provides an understandable user interface to these tools, enabling even mathematically unsophisticated users to effectively solve complex problems. The invention also incorporates sensitivity analyses, thereby permitting the user to explore how changes in input data would affect the results of the program calculations. In addition to a data-input program module, respective program modules are disclosed for managing a company product line, a securities portfolio, and a short-selling portfolio.

A method for segmenting vertebrae in digitized images includes providing a plurality of digitized whole-body images, detecting (91) and segmenting a spinal cord using 3D polynomial spinal model in each of the plurality of images, finding (92) a height of each vertebrae in each image from intensity projections along the spinal cord, and building (93) a parametric model of a vertebrae from the plurality of images. The method further includes providing a new digitized whole-body image including a spinal cord, fitting (94) an ellipse to each vertebrae of the spinal cord to find the major and minor axes, and applying (95) constraints to the major and minor axes in the new image based on the parametric model to segment the vertebrae.

In accordance with the present invention, there is provided a method for producing an enhanced fertilizer, comprising the step of mixing a granular fertilizer with a ferment comprising active bacteria in a fermentation medium, to obtain an enhanced fertilizer. The ferment is used at a rate of at most 3 liters of ferment per ton of fertilizer. In accordance with the present invention, there is also provided an enhanced fertilizer comprising a fertilizer and bacteria chosen for their specific properties on crops or vegetation.

A shield assembly for enclosing and restricting access to the port of a container including a tamper evident structure. A housing includes two segments movable between closed and opened orientations. A hollow interior of the housing, when in the closed orientation, substantially corresponds to the enclosed port. A lock assembly includes male and female members wherein a frangible structure interconnects the female member in engaging relation to the male member in a locked orientation. Passage of the male member through the female member from the locked position into an unlocked position results in detachment of the frangible structure and an enlargement of the female member sufficient to restrict the lock assembly from assuming the locked position. A tracking assembly is included and operative to identify and distinguish a plurality of shield assemblies and / or their components from one another.

The present invention relates to an efficient process for producing polylactic acid from fermentation of renewable agricultural feed-stocks not limited to molasses or cane bagasse employed as starting material. The present invention in particular provides a cost effective and industrially scalable process for producing polylactic acid obtained by fermentation of Lactic acid having industrial applications.

The present invention concerns a double confocal scanning microscope having an illuminating beam path (1) of a light source (2) and a detection beam path (3) of a detector (4), and in order to eliminate at their cause the problems of reconstruction methods. To do so, at least one optical component (24, 25) acting on the illuminating and / or detection beam path (1, 3) is provided, and is configured in such a way that it influences the amplitude and / or phase and / or polarization of the light; and the characteristics of the double confocal illumination and / or detection are thereby modifiable.

A method and apparatus are disclosed for reducing leakage power in a cache memory. A cache decay technique is employed for both data and instruction caches that removes power from cache lines that have not been accessed for a predefined time interval, referred to as the decay interval. The cache-line granularity of the present invention permits a significant reduction in leakage power while at the same time preserving much of the performance of the cache. The decay interval is maintained using a timer that is reset each time the corresponding cache line is accessed. The decay interval may be fixed or variable. Once the decay interval timer exceeds a specified decay interval, power to the cache line is removed. Once power to the cache line is removed, the contents of the data and tag fields are allowed to decay and the valid bit associated with the cache line is reset. When a cache line is later accessed after being powered down by the present invention, a cache miss is incurred while the cache line is again powered up and the data is obtained from the next level of the memory hierarchy.

A method of optimizing production of a hydrocarbon-containing reservoir by measuring low-frequency Distributed Acoustic Sensing (LFDAS) data in said well during a time period of constant flow and during a time period of no flow and during a time period of perturbation of flow and simultaneously measuring Distributed Temperature Sensing (DTS) data from said well during a time period of constant flow and during a time period of no flow and during a time period of perturbation of flow. An initial model of reservoir flow is provided using the LFDAS and DTS data; the LFDAS and DTS data inverted using Markov chain Monte Carlo method to provide an optimized reservoir model, and that optimized profile utilized to manage hydrocarbon production from said well and other asset wells.

A catalytic conformational sensor method for detecting abnormal proteins and proteinaceous particles. The method is based on the interaction of a peptide fragment or probe with an abnormal proteinaceous particle. The interaction catalyzes transformation of the probe to a predominately beta sheet conformation and allows the probe to bind to the abnormal proteinaceous particle. This in turn, catalyzes propagation of a signal associated with the test sample-bound probe. As a result signals can be propagated even from samples containing very low concentrations of abnormal proteinaceous particles as is the case in many body-fluid derived samples.

A semantics engine is described that produces a semantically-impaired but equivalent version of the original source code that can be compiled and executed using conventional tools for commonly used programming languages. This semantically-impaired source code and the compiled assemblies it produces are incomprehensible to anyone who would attempt to read them. The semantics-impairing process is irreversible both at the source and the assembly levels and the machine code generated by the semantically-impaired source code is exactly the same as that produced by the original source code. The semantics engine achieves confidentiality without using encryption or compression. All protective modifications are made directly to copies of the original source code thereby introducing no intermediate forms of the code.

Protein engineering is an emerging area that has expanded the understanding in the art of protein folding and laid the groundwork for the creation of unprecedented structures with unique functions. The first native-like pore-forming protein, small globular protein (SGP), has previously been designed. It has now been discovered that this artificially engineered protein, and analogs and homologs thereof, have membrane-disrupting properties and anti-tumor activity in several cancer animal models. A mechanism for the selectivity of SGP toward cell membranes in tumors is proposed and validated herein, thereby confirming the proposed mechanism of action. Thus, SGP is established herein as the prototype for a new class of artificial proteins designed for therapeutic applications.

The present invention relates to a small ruminant semen freezing diluent, comprising, for each 100 ml, the following components: 2.71 g of trihydroxymethyl aminomethane, 1.4 g of citric acid, 1.0 g of monosaccharide, 5-20 ml of fresh egg yolk, 0-10 ml of osmotic protective agent, 0.1 million IU of penicillin, 0.1 million IU of streptomycin, 50-600 mMol of inositol compounds, 0.1-50 μMol of resveratrol, and the rest of ultra-pure water. In this invention, resveratrol is firstly and successfully applied to the small ruminant semen freezing field, improving the quality of the frozen semen, thereby being low in costs, stable in chemical property, and simple and easy to use.

An iron-based superalloy for high temperature 700° C. with coherent precipitation of cuboidal B2 nanoparticles, belongs to the field of heat-resistant stainless steel, including Fe, Cr, Ni, Al, Mo, W, Zr, B elements. C, Si, Mn, S, P, O, N are impurity elements. The weight percent (wt. %) of its alloy composition is Cr: 10.0˜12.0, Ni: 13.0˜15.0, Al: 6.0˜7.0, Mo: 2.0˜3.0, W: 0.3˜0.7, Zr: 0.03˜0.05, B: 0.004˜0.007, C≤0.02, Si≤0.20, Mn≤0.20, S≤0.01, P≤0.02, O≤0.005, N≤0.02, Fe: balance; and the atomic percent ratio of Zr / B is 1:1, the atomic percent ratio of Cr / (Mo+W) is 8:1, and the atomic percent ratio of Mo / W is 8:1. The coherent precipitation of cuboidal B2 nanoparticles in ferritic matrix through the alloy composition design.

A fastener delivery tube (21) incorporates an internal guide (22)—such as a continuous sleeve lining, flexible, or resiliently deformable spring strips (34, 37, 38) or re-circulating balls (54)—forming a longitudinally movable constriction, inhibiting fastener free-fall through the tube and preserving fastener orientation, by maintaining fastener (25) contact with a driving plunger (28) in its passage there-through and upon exit there-from into contact with a workpiece.

A structure of phosphorous-containing functionalized poly(arylene ether), a preparation method thereof, and a composition prepared therefrom are provided. The curable (cross-linkable) composition includes an unsaturated monomer and a phosphorous-containing functionalized poly(arylene ether) having a polymerizable group and a molecular weight between 500 and 20,000. The composition provides excellent fluidity and fast curing rate. After curing, the composition exhibits excellent low dielectric coefficient and dielectric loss, high heat resistance and flame retardancy. It is suitable for prepregs, laminated sheets for printed circuits or the like.

A method for fault detection and localization calls for obtaining a data set, smoothing the data set, identifying a plurality of split points within the data set, fitting a piecewise linear function to the plurality of split points; and determining a residual between the function and the smoothed data set. Related systems and computer program products are disclosed and claimed.

The present inventions are characterized by providing a processing device, processing method and saccharifying method for extrusion cooked beer adjunct so that the saccharification and filtration of mash for the extrusion cooked beer adjunct may be carried out smoothly in the actual production for brewing beer. As compared with the double-mash saccharifying method (including the saccharifying method with additional enzymes) applied currently now, it may omit the mash cooking procedure and the cooking kettle and put the malt grist and the grist of extrusion cooked beer adjunct together into water in the brew kettle or the grist of extrusion cooked beer adjunct, malt grist and water are together put into the brew kettle to carry out the saccharifying. The single-mash saccharifying method of this invention may reduce the energy consumption, decrease the cost of beer production, increase the recoverable ratio of wort extract and raise the beer output.

The present invention discloses a reference DNA and the use thereof, wherein the reference DNA is selected from the group consisting of:(i) DNA fragment 1: characterized in that it carries a defined gene mutation and at least one another artificially altered base X2, wherein, as compared to a wild type of the gene, at least one defined base X1 in the defined gene mutation undergoes a mutation associated with the occurrence, diagnosis, and / or treatment (such as a target targeted by a medicament) of a disease (such as a tumor), wherein the mutation is a substitution mutation, a deletion mutation, and / or an insertion mutation, and the artificially altered base X2 is different from the mutant base X1 which is contained in the DNA of a sample to be detected and defined to be associated with the occurrence, diagnosis and / or treatment of a disease,(ii) DNA fragment 2: characterized in that it differs from the DNA fragment 1 only in that it does not comprise the defined base X1 mutation, or(iii) a mixture of the DNA fragment 1 and the DNA fragment 2.

A 68Ge / 68Ga generator for a continuous production of a 68Ga daughter nuclide, wherein the 68Ge parent nuclide thereof is specifically adsorbed to an inorganic support material and wherein said 68Ge parent nuclide continuously decays to 68Ga by electron capture at a half-life of 270.82 d, wherein the inorganic support material is at least one oxide of a metal being selected from the group consisting of: Vanadium, Niobium and Tantalum. The use of at least one oxide of a metal being selected from the group consisting of: Vanadium, Niobium and Tantalum as an inorganic support material for the manufacture of a 68Ge / 68Ga generator for pharmaceutical purposes. With the inorganic support material of the present invention, it is possible to load 68Ge / 68Ga generators with up to 8000 MBq of 68Ge (corresponding to 80 μg Germanium).

A quick, simple, and efficient in vitro method for generating a random chimeric or mutated gene or genes in a circular polynucleotide molecule. The method is based on hybridization of random DNA fragments to a closed, circular DNA template, elongation of the fragments by a DNA polymerase, and ligation of the fragments to each other by a DNA ligase resulting in a recombined, closed circular DNA molecule which functions as a new template in a next cycle of chimerization. The degree of recombination can be controlled by the number of cycle repetitions, the amount of different templates and fragments, and the ratio of the latter. This procedure is referred to as polymerase chain chimerization (PCC). The PCC method is useful for generating new, improved bio-molecules.

Systems and methods are disclosed for spatially and temporally mapping safer and riskier and wellbeing areas based on perceived safety / risk and wellbeing, related to perceived viral mitigating health behaviors, known built environment wellbeing features, and predictively modelling movement through locations, and building environment features and operations contributing to viral spread.