The invention discloses a spraying agent for degrading indoor harmful substances and a preparation method of the spraying agent, specifically to the field of environment-friendly decoration. The spraying agent comprises the following components in parts by weight: 10-15 parts of a photocatalyst, 5-10 parts of chitosan, 5-10 parts of nano transition metal powder, 10-15 parts of an adsorbent, 20-30parts of acetic acid, 5-7 parts of sodium bicarbonate, 10-20 parts of a robinia pseudoacacia ethanol extract, 5-10 parts of a melia azedarach ethanol extract, 10-15 parts of a chrysanthemum flos ethanol extract and 80-100 parts of deionized water. The spraying agent and the preparation method provided by the invention have the advantages of being short in time in decomposing harmful gases, low inprice, convenient to use, and the like.