To provide a skin care composition having effects of anti-inflammation, moisturization, and whitening of skin yellowing.SOLUTION: The present invention discloses application of a fermentation product in preparing reagents for anti-inflammation, moisturization, or whitening of skin yellowing, the fermentation product is prepared from thermus thermophilus and yeast through fermentation co-culture, a thermus thermophilus and yeast co-fermentation method comprising the following steps: firstly, carrying out bacterium increase fermentation once or multiple times on yeast at low temperature under acidic condition after a logarithmic phase, increasing the temperature of a fermentation liquid to a high temperature from a low temperature, adding thermus thermophilus, and carrying out secondary fermentation under alkaline condition. The method includes the steps of: (1) performing one-time or multi-time fermentation to saccharomyces cerevisiae at low temperature under acidic condition, thus reproducing the yeast; and (2) when the yeast is in a later period of a logarithmic phase, increasing the temperature, inoculating the thermus thermophilus, and performing second fermentation under alkaline condition, thereby producing a fermentation product.SELECTED DRAWING: Figure 1