36results about How to "Reduce direct stimulation" patented technology

The invention discloses an uncaria slow release capsule preparation and a preparation method thereof. The preparation is prepared from 1 to 15 parts by weight of uncarine or uncaria rhomotoxine and 73.2 to 130.2 parts by weight of accessories, wherein the accessories comprise 65 to 85 parts of excipient, 3 to 15 parts of coating agent, 5 to 20 parts of wetting agent, 0.1 to 0.5 part of surface active agent, 0 to 9 parts of plasticizer and 0.1 to 0.7 part of sunscreen. Compared with the prior art, by a slow release technology of the invention, medicaments are slowly released; the fluctuation of the concentration of plasma medicaments is effectively reduced; a peak valley phenomenon caused by frequent administration of an ordinary preparation is avoided; the utilization rate of the medicaments is enhanced; the medical cost is reduced; and the direct stimulation of the medicaments for the gastrointestinal tract is reduced. Therefore, side effects are reduced; patients are easy to endure the medicaments; and the preparation is beneficial to long-term treatment and hypertensive treatment. In addition, the invention also simplifies the technology; the preparation process of a capsule is easier to operate and more convenient to carry and take; the problem of the prior art is solved; and the purpose of the invention is achieved.

The invention relates to the technical field of medicines and provides a metformin hydrochloride medicine composition as well as a preparation method and application thereof. The metformin hydrochloride medicine composition comprises the following components in parts by weight: 100-150 parts of metformin hydrochloride, 5-10 parts of pregelatinized starch, 5-10 parts of mannitol and 1-5 parts of magnesium stearate. The preparation method comprises the following steps: uniformly mixing the metformin hydrochloride, the pregelatinized starch and the mannitol, adding water to pelletize, further adding the magnesium stearate, and uniformly mixing, thereby obtaining capsules or tablets. According to the embodiment of the invention, contents of the metformin hydrochloride, the pregelatinized starch and the mannitol are limited, medicines are slowly released in bodies, direct irritation of the metformin hydrochloride to gastrointestinal tracts can be alleviated, side effects, particularly serious gastrointestinal tract reactions, can be reduced, an effective blood concentration can be maintained, the compliance and the security of medicine taking can be improved for patients, the patients can tolerate the composition, and long-term treatment can be facilitated.

The invention relates to the technical field of medicine, and provides a moxifloxacin hydrochloride pharmaceutical composition, a preparation method and application thereof. The moxifloxacin hydrochloride pharmaceutical composition comprises, in parts by weight, 40-50 parts of moxifloxacin hydrochloride, 4-5 parts of pregelatinized starch, 10-15 parts of microcrystalline cellulose, cross-linked carboxymethyl 3-4 parts of cellulose sodium and 0.3-1 part of magnesium stearate; the preparation method comprises mixing moxifloxacin hydrochloride, pregelatinized starch, microcrystalline cellulose and cross-linked carboxymethyl cellulose sodium, adding water Granulate, then add magnesium stearate, mix well and make capsules or tablets. In this example, by limiting the content of the components, the drug can be released slowly in the body, reducing the direct stimulation of moxifloxacin hydrochloride to the gastrointestinal tract, thereby reducing its side effects, especially the occurrence of severe gastrointestinal reactions, and improving the quality of the patients. The compliance and safety of medication make it easier for patients to tolerate and benefit long-term treatment.