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129results about How to "Reduce and avoid" patented technology

Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents

Systems and methods are presented for cell simulation and cell state prediction. For example, a cellular biochemical network intrinsic to a phenotype of a cell can be simulated by specifying its components and their interrelationships. The various interrelationships can be represented with one or more mathematical equations which can be solved to simulate a first state of the cell. The simulated network can then be perturbed, and the equations representing the perturbed network can be solved to simulate a second state of the cell which can then be compared to the first state, identifying the effect of such perturbation on the network, and thereby identifying one or more components as targets. Alternatively, components of a cell can be identified as targets for interaction with therapeutic agents based upon an analytical approach, in which a stable phenotype of a cell is specified and correlated to the state of the cell and the role of that cellular state to its operation. A cellular biochemical network believed intrinsic to that phenotype can then be specified, mathematically represented, and perturbed, and the equations representing the perturbed network solved, thereby identifying one or more components as targets.
Owner:CORNELL RES FOUNDATION INC +1

Apparatus having partially gold-plated surface

InactiveUS20010021372A1Reduce or avoidChange in surface propertyBiocideFlow mixersPolymer chemistrySteam sterilization
A change in the surface properties of apparatus for pharmaceutical preparation results from steam sterilization. This change may be avoided by the use of apparatus with more hydrophilic post-sterilization surfaces, e.g. those of gold. Hence there is provided a process for the preparation of a mixture comprising a discontinuous phase in a continuous phase which comprises using a mixing apparatus having a non-porous mixing surface which is repellant to the discontinuous phase and / or attractive to the continuous phase when the continuous phase is liquid or which is attractive to the discontinuous phase when the continuous phase is gaseous, whereby to improve the efficacy of the preparation of said mixture and / or to reduce physical degradation of said mixing surface, said surface if hydrophilic being more hydrophilic after sterilization than is stainless steel and if hydrophobic being more hydrophobic after sterilization than is stainless steel.
Owner:AMERSHAM HEALTH

Memory access system

The ECC circuit generates the first syndrome of write data, which have not been written to the memory. The EDC circuit generates the second syndrome of verification read data, which have been written to the memory. The EDC circuit detects errors due only to the “read disturb phenomenon” using the second syndrome, the errors occurring in data scanned from the memory. The ECC circuit detects and corrects errors due to the “program disturb phenomenon” and the “read disturb phenomenon” using the first syndrome, the errors occurring in the data in which the errors due only to the “read disturb phenomenon” have been detected. As a result, both the circuit size and the processing time can be reduced.
Owner:MEGACHIPS

Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents

Systems and methods for modeling the interactions of the several genes, proteins and other components of a cell, employing mathematical techniques to represent the interrelationships between the cell components and the manipulation of the dynamics of the cell to determine which components of a cell may be targets for interaction with therapeutic agents. A first such method is based on a cell simulation approach in which a cellular biochemical network intrinsic to a phenotype of the cell is simulated by specifying its components and their interrelationships. The various interrelationships are represented with one or more mathematical equations which are solved to simulate a first state of the cell. The simulated network is then perturbed by deleting one or more components, changing the concentration of one or more components, or modifying one or more mathematical equations representing the interrelationships between one or more of the components. The equations representing the perturbed network are solved to simulate a second state of the cell which is compared to the first state to identify the effect of the perturbation on the state of the network, thereby identifying one or more components as targets. A second method for identifying components of a cell as targets for interaction with therapeutic agents is based upon an analytical approach, in which a stable phenotype of a cell is specified and correlated to the state of the cell and the role of that cellular state to its operation. A cellular biochemical network believed to be intrinsic to that phenotype is then specified by identifying its components and their interrelationships and representing those interrelationships in one or more mathematical equations. The network is then perturbed and the equations representing the perturbed network are solved to determine whether the perturbation is likely to cause the transition of the cell from one phenotype to another, thereby identifying one or more components as targets.
Owner:HILL COLIN +2

Preparation method of LCZ696 intermediate

The invention discloses a preparation method of LCZ696 intermediate and relates to the technical field of preparation of an aromatic nucleus compound containing 2 benzene rings and 1 chiral center. The preparation method includes the steps of S1, allowing benzyl magnesium bromide to react with methyl oxalyl chloride to obtain a compound as shown in formula I; S2, allowing the compound as shown in formula I to have a bromination reaction with a bromination reagent to generate a compound as shown in formula II; S3, coupling the compound as shown in formula II with phenylboronic acid to obtain a compound as shown in formula III; S4, performing reductive ammoniation on the compound as shown in formula III to obtain a compound as shown in formula IV; S5, applying Boc to the compound as shown in formula IV to obtain a compound as shown in formula V; S6, performing ester group reduction on the compound as shown in formula V to obtain a compound as shown in formula VI. The preparation method has the advantages that overall raw material consumption is lowered, and product productivity and market competiveness are increased; by the overall process optimization, the reaction of each step can be performed and controlled easily, the use of heavy metal catalysts is reduced and avoided, and accordingly the quality index of the final product is increased, and an economic and environment-friendly process route is developed.
Owner:CANGZHOU SENARY CHEM SCI TEC

Carrier guide and firearm

Firearms having a carrier assembly, buffer systems, and methods, having a carrier spindle, carrier saddle, or both, to reduce carrier tilt or wobble, reduce wear, or both. A carrier spindle can be located forward of the buffer spring, buffer weight, or both, and aft of the carrier assembly, and can slidably engage the carrier assembly. A spindle spring can bias the carrier spindle aft from the carrier assembly. In some embodiments, a taper on the carrier spindle facilitates separation of the lower receiver from the upper receiver. In some embodiments, the spindle spring is a helical spring that is loaded in compression and pushes the carrier spindle aftward. Some embodiments include a carrier saddle that supports the aft end of the carrier assembly. The carrier saddle can be raised, have a concave top surface, be made of a softer material, have dimensions within certain ranges, or a combination thereof.
Owner:FALKOR SID INC
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