The invention discloses a high-toughness titanium alkaline type seamless flux-cored wire suitable for all-position welding. The flux-cored wire is composed of a low-carbon steel strip at the peripheryand flux core powder inside; and the flux core powder comprises the following components, by weight percentage: 30-40% of rutile, 1-2% of aluminum oxide, 2-4% of dehydrated feldspar, 1-3% of quartz,1-3% of zircon sand, 1-2% of rare earth oxide, 1-2% of silicon powder, 0.2-0.4% of ferroboron, 6-8% of nickel powder, 8-15% of metal manganese, 4-9% of magnesium powder and the balance iron powder andinevitable impurities. According to the flux-cored wire, a titanium alkaline slag system is adopted, the proportion of alloy elements is optimized, the content of mineral powder is adjusted, and under the protection of CO2 gas, horizontal, transverse and vertical position welding can be realized; the mechanical property is stable, the impact power at 40 DEG C below zero reaches 100J, the crack resistance is good, diffusible hydrogen is low, the moisture resistance is strong, the seawater corrosion resistance is good, and the anti-cracking ability is good.