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42results about How to "Reaction conditions are readily available" patented technology
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Method for preparing lithium difluorophosphate
The invention relates to the field of lithium battery electrolyte additives and in particular to an economic preparation method suitable for industrially producing lithium difluorophosphate. The method at least comprises the following steps: (1), enabling an oxidized boron compound to react with lithium hexafluorophosphate, to obtain a lithium difluorophosphate mixture; and (2), concentrating thelithium difluorophosphate mixture, adding a poor solvent, crystallizing, and separating to obtain the lithium difluorophosphate.
Owner:SHANGHAI ROLECHEM CO LTD
Method for preparing iron/copper aza graphene zinc air battery cathode catalyst
ActiveCN110247068AGood electrocatalytic oxygen reduction (ORR) activityEasy to prepareFuel and primary cellsCell electrodesIron oxyhydroxideZinc–air battery
The invention belongs to the field of zinc air batteries, and discloses a method for preparing an iron / copper aza graphene zinc air battery cathode catalyst, comprising the following steps of: (1) mixing iron oxyhydroxide, copper hydroxide, graphene oxide and graphite phase carbon nitride (g-C3N4), and adding sodium alginate to obtain a gel; (2) placing the gel into a quartz tube closed at one end, vacuumizing the quartz tube by a centrifugal pump, and calcining the quartz tube in a muffle furnace at 750 to 950 degrees centigrade for 10 to 20 minutes, and then cooling the quartz tube at room temperature; (3) immersing a black solid obtained in the previous step in a hydrochloric acid for 8 to 12 hours at 50 to 80 degrees centigrade, washing a product with deionized water and ethanol to neutral, drying the product, placing the dried black powders in the quartz tube closed at one end, vacuumizing the quartz tube, calcining the quartz tube at 750 to 850 degrees centigrade for 10 to 20 minutes, and cooling the product to obtain the iron / copper aza graphene. The method is convenient and efficient. The prepared catalyst is an amorphous structure, and has high electrocatalytic oxygen reduction activity and good stability, and has a very good application prospect.
Owner:JIANGSU UNIV
Process for semi-synthesizing of apiolin
The invention discloses a semi compounding method for apium celery element that uses natural extract as basic raw material. It uses pomelo peel element as raw material, 1, 4-dioxy cyclohexane as reaction solvent, taking oxidative dehydrogenation reaction with iodine to form raw apium celery element. Taking multi-steps recrystallizing, the refined apium celery element would be gained. The invention is easy to operate, stable reacting condition, easy to control. The yield would be 60-70% and the purity could be over 97%. And it is low cost, no harmful to the environment.
Owner:ZHEJIANG TIANCAO BIOTECHNOLOGY CO LTD
Synthetic method of novel chiral non-cycle purine nucleoside analogue
InactiveCN104557936AFew reaction stepsChiral sources are readily availableOrganic chemistryEpoxySide chain
The invention discloses a synthetic method of a novel chiral non-cycle purine nucleoside analogue. The method has the beneficial effects that reaction steps are few, a chiral source is easily available, reaction conditions are relatively mild, and meanwhile, a side chain containing two chiral centers can be constructed; reference values are provided for synthesis and application of non-cycle nucleoside drugs, and a raw material is provided for the research of novel antiviral and anti-tumor drugs; meanwhile, an effective effect is provided for the construction of other non-cycle nucleosides and analogues of the other non-cycle nucleosides; furthermore, the method has wide industrial application prospect. The method comprises the steps of firstly carrying out Sharpless epoxidation reaction to obtain epoxy propenol compounds with relatively high Ee value and yield, and opening cycles of the chiral epoxy compounds by virtue of a purine base, so as to obtain the novel non-cycle nucleoside analogue containing two chiral centers, wherein an aryl substituent is located at a site 1' of the novel non-cycle nucleoside analogue.
Owner:HENAN INST OF SCI & TECH
Method for synthesizing biapenem medicine intermediates
ActiveCN108069998ARoute raw materials are cheap and easy to getSimple stepsGroup 4/14 element organic compoundsBiapenemMedicinal chemistry
The invention discloses a method for synthesizing biapenem medicine intermediates. The method has the advantages that the biapenem medicine intermediates 4-AA are prepared from (R)-3-polyhydroxybutyrate which is a raw material, and the raw material in the routes is inexpensive, is easily available and can be substantially purchased; the method includes simple steps, the various steps are high in yield, and reaction is simple; chiral reagents and chiral resolution are omitted, accordingly, the method is low in cost and high in yield, and reaction conditions are easily available.
Owner:ZHEJIANG GONGSHANG UNIVERSITY +2
Economic and efficient method for asymmetric synthesis of R-configuration aromatic alcohol through copper salt catalysis
InactiveCN104402661AHigh yieldIncrease enantiomeric excess valueOrganic compound preparationHydroxy group formation/introductionSilanesNitrogen gas
The invention relates to an economic and efficient method for asymmetric synthesis of R-configuration aromatic alcohol through copper salt catalysis, and belongs to the technical field of preparing optically active alcohol through catalysis asymmetric hydrosilation. According to the method, Cu salt and chiral bisphosphine ligand form a clathrate with a certain spatial configuration, and a substance with catalytic activity is formed by in-situ reaction under the action of stoichiometric hydrogenous silane and is used for preparing the R-configuration aromatic alcohol with asymmetric catalysis hydrosilation reduction aromatic ketone. According to the method, a non-noble metal catalyst is adopted, raw materials are easy to get, nitrogen protection is not needed, reaction condition is mild, operation is simple, use of hazardous articles, such as hydrogen, can be avoided, the method is safe, reliable and environmental-friendly, atom economy is good, substrate conversion rate is up to 99%, an enantiomer excess value of the product of the R-configuration aromatic alcohol is up to 93%, the simple, direct and efficient new method is provided for preparing chiral aromatic alcohol, and the method has an important industrial application value.
Owner:JIANGNAN UNIV
Method for preparing ethyl 2-oxo-4-phenylbutyrate
InactiveCN101928219AGood reaction selectivityHigh yieldOrganic compound preparationCarboxylic acid esters preparationGrignard reagentOxygen
The invention relates to a method for preparing ethyl 2-oxo-4-phenylbutyrate, which comprises the following steps: (1) reacting beta-halogeno ethylbenzene with magnesium in a first aprotic solvent to obtain a Grignard solution containing a Grignard reagent; (2) reacting ethyl oxalyl monochloride with one or more of CuX, Li2CuX4 and CuCN.LiX in a second aprotic solvent to obtain a solution containing a copper acyl chloride salt compound; and (3) dropwise adding the Grignard solution in the solution obtained in step (2), persevering the temperature at -20-160 DEG C, enabling the Grignard reagent to react with the cooper acyl chloride salt compound to obtain a product solution after the reaction is finished, carrying out acidic hydrolysis and alkali neutralisation on the product solution in sequence, washing, drying and removing the solvent, and obtaining the ethyl 2-oxo-4-phenylbutyrate with the purity no less than 97% after high vacuum rectification. The invention has the advantages of good reaction selectivity, high yield, easily obtained raw materials, mild reaction conditions, convenient operation and low cost.
Owner:太仓浦源医药原料有限公司
Nickel-cerium biochar catalyst as well as preparation method and application thereof
PendingCN114272932AWide variety of sourcesLow costOrganic chemistryOrganic compound preparationLignin degradationPtru catalyst
The invention relates to the field of lignin degradation, in particular to a nickel-cerium biochar catalyst and a preparation method and application thereof.The nickel-cerium biochar catalyst comprises biochar serving as a carrier and active components loaded on the biochar, and the active components comprise nickel and cerium; the content of nickel is 1-10 wt.%, the content of cerium is 1-10 wt.%, and the balance is charcoal. According to the application, the nickel-cerium biochar catalyst is applied to catalytic depolymerization of lignin. According to the nickel-cerium biochar catalyst, the raw material for preparing the biochar is lignin, the lignin widely exists in the nature, is low in obtaining cost, can be regenerated, can effectively reduce the depolymerization cost and is suitable for large-scale industrial application, and the nickel-cerium biochar catalyst is matched with a crude glycerine system, so that the nickel-cerium biochar catalyst is of great benefit to green utilization of an industrial byproduct crude glycerine, and is suitable for large-scale industrial application. The lignin depolymerization efficiency is high, the conversion rate of the lignin can reach 78% or above, the selectivity of guaiacol and derivatives thereof exceeds 82%, and the selectivity of the monomer guaiacol exceeds 41%.
Owner:ANHUI UNIV OF SCI & TECH
Bionic dry-wet adhesive force self-adjusting dressing and preparation method and application thereof
The invention discloses a bionic dry-wet adhesive force self-adjusting dressing. The bionic dry-wet adhesive force self-adjusting dressing comprises the following components in parts by weight: 7-8 parts of styrene-isoprene-styrene block copolymer; 5-6 parts of high molecular weight polyisobutene; 10-12 parts of low molecular weight polyisobutene; 4-5 parts of tackifying resin; 0.5-0.7 part of anti-aging agent; 3-3.5 parts of naphthenic oil; 11-13 parts of sodium carboxymethyl cellulose; 3-3.5 parts of chitosan; and 3.2-5.5 parts of microcrystalline cellulose; the size of the microcrystalline cellulose is 20-50 [mu]m. According to the bionic dry-wet adhesive force self-adjusting dressing of the invention, due to addition of the microcrystalline cellulose, and the size and the shape of the dressing basically remain unchanged after the dressing is in contact with the surface of a wound due to hydrophobic and water-guiding effects of the microcrystalline cellulose, the hardness of the dressing after moisture absorption is improved, and the adhesive force of the dressing after moisture absorption is further improved; different adhesive forces are shown according to different dryness and wetness of the contact surface, so that the problem that the dressing is easy to soften and lose viscosity after absorbing moisture is solved, and the experience feeling of a patient is improved.
Owner:HUBEI UNIV
Porous composite material long-term sugar control system and preparation method and application thereof
ActiveCN110639027AHigh specific surface areaStablePeptide/protein ingredientsMetabolism disorderComposite materialChemical bond
The invention discloses a porous composite material long-term sugar control system and a preparation method and application thereof. The porous composite material long-term sugar control system is formed by combining FITC modified NH2-PEG-SH and a porous material embedded with sugar control drugs, and then assembling; and a hydrophobic end and a hydrophilic end are contained, wherein the hydrophobic end is formed by embedding the sugar control drugs in the porous material, and the hydrophilic end is formed by chemical bond reaction of NH2-PEG-SH and FITC. The porous composite material long-term sugar control system has high loading capacity and excellent luminous characteristics, can be evenly and stably dispersed in an aqueous solution, and can long-term embed novel materials maintainingactivity of pancreas islet, and fast and stable blood glucose control is achieved.
Owner:ANHUI MEDICAL UNIV
Adapter-modified magneto-optic dual-function contrast agent and preparation method and application thereof
InactiveCN102397566AImprove luminosityUniform particle sizeMicrobiological testing/measurementNMR/MRI constrast preparationsPolyethylene glycolIsothiocyanic acid
The invention discloses an adapter-modified magneto-optic dual-function contrast agent and a preparation method and application thereof. The contrast agent comprises silicon dioxide-coated trimanganese tetroxide nanoparticles, wherein the diameters of trimanganese tetroxide nanoparticles are 6-8 nanometers; the thickness of a silicon dioxide coating layer is 8-12 nanometers; the surface of the silicon dioxide coating layer is provided with an amino group and is coupled with a rhodamine isothiocyanate molecule and dicarboxyl polyethylene glycol through the amino group; and the dicarboxyl polyethylene glycol is connected with an adapter with an amino group. The contrast agent obtained in the invention has high monodispersity, high biocompatibility and targeting property, can be taken as a good T1 magnetic resonance imaging contrast agent, has high targeting property on tumor cells, and has wide application value in the fields of medicaments and biology; and the preparation method provided by the invention has the advantages of very low requirements on equipment, convenient operation process, low prices of need raw materials and nuisanceless byproducts.
Owner:SHANGHAI NORMAL UNIVERSITY
Synthetic method of carbapenem antibiotic drug intermediate
ActiveCN108586517ARoute raw materials are cheap and easy to getSimple stepsGroup 4/14 element organic compoundsMedicinal chemistryCarbapenem Antibiotics
The invention discloses a synthetic method of a carbapenem antibiotic drug intermediate. By using (R)-3-hydroxybutyrate as the raw material, the carbapenem antibiotic drug intermediate 4-AA is prepared. Raw materials for the process are cheap and easily-available and can be purchased in quantity. The synthetic method has simple steps, yield of each step is high, and reactions are simple. By usinga chiral column as the split chiral center, use of a precious metals chiral reducing catalyst is avoided. the synthetic method of the invention has the following advantages: cost is low; yield is high; and reaction conditions are easily available.
Owner:ZHEJIANG GONGSHANG UNIVERSITY +2
Preparation of 2ZnO.3B2O3.3.5H2O zinc borate
The invention discloses a method for producing 2ZnO 3B2O3 3.5H2O (zinc borate), which is to make the 237 zinc borate react under a constant temperature in the water solution of boric acid for a certain period; then filter and wash directly upon the completion of the reaction, recover the washing liquid and the filtrate can be recovered for repetitive use; finally dry the filter cake to obtain the2ZnO 3B2O3 3.5H2O (zinc borate). The method of the invention has simple technique, the production process does not discharge wastewater and the production cost is low. The product can be used for flame-retardant material or daily chemical field, biological medicine field and so on.
Owner:常熟紫金知识产权服务有限公司
NiFe-PBAs-F catalyst with multistage structure as well as preparation method and application thereof
ActiveCN112626559AFacilitate surface remodelingImprove conductivityElectrodesNickel saltPtru catalyst
The invention discloses a NiFe-PBAs-F catalyst with a multistage structure as well as a preparation method and application thereof. The preparation method comprises the following steps: enabling foamed nickel to react in a mixed solution of nickel salt and hexamethylene tetramine to obtain Ni(OH)2 nano sheets; putting Ni(OH)2 nano sheets growing on a foamed nickel substrate into a mixed solution of nickel salt, sodium citrate and potassium ferricyanide, and reacting to prepare a NiFe-PBAs@Ni(OH)2 multistage structure; and mixing the prepared NiFe-PBAs@Ni(OH)2 multistage structure with NH4F in an inert atmosphere, and carrying out heat treatment to obtain the NiFe-PBAs-F catalyst with a multistage structure. According to the NiFe-PBAs-F catalyst with a multistage structure, the original frame structure of NiFe-PBAs-F can be maintained, and a more convenient substance transmission channel can be provided. In addition, the catalyst achieves violent reconstruction in the OER process, and more nickel oxyhydroxide and nickel hydroxide are generated.
Owner:SHANDONG UNIV
Manganese dioxide super-long nanowire catalyst with oxygen vacancies as well as preparation method and application of manganese dioxide super-long nanowire catalyst
ActiveCN112981454AIncrease contact areaImprove electrochemical stabilityMaterial nanotechnologyManganese oxides/hydroxidesNanowirePtru catalyst
The invention relates to a manganese dioxide super-long nanowire catalyst with oxygen vacancies as well as a preparation method and application of the manganese dioxide super-long nanowire catalyst. The MnO2 super-long nanowire catalyst is of a 3D network structure composed of super-long MnO2 nanowires, the diameter of the nanowires is about 10 nm, the interplanar spacing is 0.69 nm, and the nanowires have lattice distortion and oxygen vacancies. The preparation method comprises the following steps: by taking carbon paper as a conductive substrate, putting the carbon paper into a potassium permanganate solution for hydrothermal reaction, and obtaining the MnO2 super-long nanowire catalyst on the carbon paper. In the hydrothermal reaction process, oxygen vacancies can be spontaneously formed, and the electronic structure of MnO2 is improved. Growth is carried out on the surface of the carbon paper to form a 3D structure, so that active sites with higher density can be exposed. The electro-catalysis nitrogen reduction performance can be effectively improved. Electro-catalytic nitrogen reduction can be carried out at room temperature.
Owner:SHANDONG UNIV
POSS-based adsorbent for heavy metal ions and thiol-ene click chemistry preparation method
InactiveCN110215903AReaction conditions are readily availableMild reaction conditionsOther chemical processesWater contaminantsChemical reactionThiol
The invention discloses a POSS-based adsorbent for heavy metal ions and a preparation method of the adsorbent, and belongs to the fields of environmental protection and material science. The adsorbenthas a structure represented by a formula (I) shown in the description. The preparation method comprises the following steps: performing a thiol-ene click chemistry reaction by using octavinyloctasilasesquioxane and mercaptothiadiazole as raw materials at room temperature to obtain the POSS-based adsorbent having the characteristics of the structure represented by the formula (I) for the heavy metal ions. The method provided by the invention is simple, high-efficiency, green and controllable, has mild reaction conditions, a simple treatment process, and discards a noble metal catalyst (such asa metal platinum catalyst) or complicated and harsh reaction conditions used in preparation of an adsorbent in the prior art; and the obtained adsorbent has the advantages of a fast adsorption speed,high saturated adsorption capacity and stable adsorption performance.
Owner:HUNAN UNIV OF TECH
A method for extracting odorless dha oil
ActiveCN104513704BLoss rate zeroReduce volumeFatty-oils/fats productionEdible oils/fatsDissolutionHigh pressure
Owner:湖北福星生物科技有限公司
A kind of method for preparing lithium difluorophosphate
Owner:SHANGHAI ROLECHEM CO LTD
Method for synthesizing (E)-2-hexenoic acid
InactiveCN101602663AClean and environmentally friendly productionRaw materials are easy to getOrganic-compounds/hydrides/coordination-complexes catalystsCarboxylic preparation by ozone oxidationMalonateLower yield
The invention provides a method for synthesizing (E)-2-hexenoic acid. The method comprises the following steps: using ethyl malonate as a raw material, and performing Knovenagel reaction, hydrolysis and decarboxylation on the ethyl malonate in a water phase to synthesize the (E)-2-hexenoic acid. Aiming at problems of strict reaction condition, serious side reaction, low yield and usage of a toxic reagent in the prior method for synthesizing the (E)-2-hexenoic acid, the method uses water as a reaction medium to realize clean and environment-friendly production without pollution, and has accessible raw materials with low cost, mild reaction condition, simple operation and easy industrialization. The synthesis method has few side reactions, and yield up to 75 to 85 percent.
Owner:CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
Method for synthesizing (E)-2-hexenoic acid
InactiveCN101602663BRealize clean and environmentally friendly productionRaw materials are easy to getOrganic-compounds/hydrides/coordination-complexes catalystsCarboxylic preparation by ozone oxidationSynthesis methodsMalonate
Owner:CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
Bismuth vanadate photoanode and its preparation method and application
ActiveCN112410814BRapid water oxidation kineticsIncrease contactMaterial nanotechnologyEnergy inputElectron holeBismuth vanadate
The invention discloses a bismuth vanadate photoanode and its preparation method and application. The preparation method is as follows: sequentially preparing a bismuth vanadate layer and a carbon sphere layer on the surface of a transparent conductive substrate, and then repeatedly preparing a bismuth vanadate layer and a carbon sphere layer , so that an active layer is formed on the surface of the transparent conductive substrate, the active layer is formed by interlacing n-layer bismuth vanadate layers and n-1 layers of carbon sphere layers, the outermost layers on both sides of the active layer are bismuth vanadate layers, n is a natural number greater than 1; the bismuth vanadate precursor solution is spin-coated into a bismuth vanadate precursor film, then dried and calcined to form a bismuth vanadate layer; the bismuth vanadate precursor solution contains vanadium salt and bismuth salt; The carbon sphere dispersion liquid is spin-coated to form a carbon sphere film, and then dried to form a carbon sphere film. The bismuth vanadate photoanode provided by the present invention has higher electron-hole separation efficiency and fast water oxidation kinetics, so that it can achieve higher photocurrent density at lower bias voltage, showing higher Solar utilization.
Owner:SHANDONG UNIV
Method for preparing ethyl 2-oxo-4-phenylbutyrate
InactiveCN101928219BGood reaction selectivityHigh yieldOrganic compound preparationCarboxylic acid esters preparationGrignard reagentOxygen
The invention relates to a method for preparing ethyl 2-oxo-4-phenylbutyrate, which comprises the following steps: (1) reacting beta-halogeno ethylbenzene with magnesium in a first aprotic solvent to obtain a Grignard solution containing a Grignard reagent; (2) reacting ethyl oxalyl monochloride with one or more of CuX, Li2CuX4 and CuCN.LiX in a second aprotic solvent to obtain a solution containing a copper acyl chloride salt compound; and (3) dropwise adding the Grignard solution in the solution obtained in step (2), persevering the temperature at -20-160 DEG C, enabling the Grignard reagent to react with the cooper acyl chloride salt compound to obtain a product solution after the reaction is finished, carrying out acidic hydrolysis and alkali neutralisation on the product solution in sequence, washing, drying and removing the solvent, and obtaining the ethyl 2-oxo-4-phenylbutyrate with the purity no less than 97% after high vacuum rectification. The invention has the advantages of good reaction selectivity, high yield, easily obtained raw materials, mild reaction conditions, convenient operation and low cost.
Owner:太仓浦源医药原料有限公司
A kind of synthetic method of penem drug intermediate
ActiveCN108069998BRoute raw materials are cheap and easy to getSimple stepsGroup 4/14 element organic compoundsButyrateBiapenem
The invention discloses a method for synthesizing biapenem medicine intermediates. The method has the advantages that the biapenem medicine intermediates 4-AA are prepared from (R)-3-polyhydroxybutyrate which is a raw material, and the raw material in the routes is inexpensive, is easily available and can be substantially purchased; the method includes simple steps, the various steps are high in yield, and reaction is simple; chiral reagents and chiral resolution are omitted, accordingly, the method is low in cost and high in yield, and reaction conditions are easily available.
Owner:ZHEJIANG GONGSHANG UNIVERSITY +2
A kind of molybdenum-boron/sepiolite catalyst and its preparation method and application
ActiveCN109675550BImprove conversion rateHigh selectivityOrganic compound preparationChemical recyclingPtru catalystDepolymerization
The invention discloses a molybdenum-boron / sepiolite catalyst and its preparation method and application. The molybdenum-boron / sepiolite catalyst includes sepiolite as a carrier and the active component loaded on the sepiolite molybdenum and boron. The molybdenum-boron / sepiolite catalyst of the present invention has a wide range of sources of raw material sepiolite, low cost, environmental protection, can effectively reduce depolymerization costs, and is suitable for large-scale industrial applications, and the molybdenum-boron / sepiolite catalyst of the present invention Cooperating with the supercritical system, the conversion rate of depolymerized lignin is high, the selectivity of substituted phenols and carboxylic acid compounds is high, and the catalyst can be recycled more than 50 times.
Owner:ANHUI UNIV OF SCI & TECH
Formula and preparation method of composite papermaking pre-flocculant
InactiveCN113718549AGood pre-flocculation effectEasy to useNon-macromolecular organic additionPaper/cardboardFlocculationPapermaking
The invention provides a formula and a preparation method of a composite papermaking pre-pre-flocculant. The composite papermaking pre-flocculant comprises the following components in parts by mass: 8-15 parts of water; 4-5 parts of epichlorohydrin; 2-3 parts of ethidene diamine; 2-3 parts of hexadecyl dimethyl amine; and 0.2-0.5 parts of a cross-linking agent. The preparation method of the composite papermaking pre-flocculant comprises the following steps of: selecting raw materials in parts by mass for later use; adding the water, the hexadecyl dimethyl amine, the ethylene diamine and the cross-linking agent in parts by mass into a reaction kettle, and mixing and stirring well; and slowly adding the epichlorohydrin in parts by mass into the reaction kettle, heating to 65-70 DEG C, and keeping the constant temperature for 4.5-5 hours. The flocculant prepared by combining the formula of the composite papermaking pre-flocculant with the method is alkaline, is adjusted to be neutral by adding acid before use, is convenient to use, has a good pre-flocculation effect, can achieve an expected flocculation effect with a small amount, and has an excellent and stable flocculation effect.
Owner:苏州欧亦博工业科技有限公司
Preparation method of 2-aryl-pentyne-4-olic acid ester compounds
ActiveCN102276467BQuality controllableHigh purityOrganic compound preparationCarboxylic acid esters preparationArylPhotochemistry
The invention relates to a preparation method of 2-aryl-pentyne-4-olic acid ester compounds with a structure shown in a formula I, wherein R is described in the specification. The preparation method has the advantages of low cost and availability of raw materials, mild reaction conditions, simpleness in operation and suitability for industrial production.
Owner:QILU PHARMA HAINAN
A kind of synthetic method of carbapenem antibiotic drug intermediate
ActiveCN108586517BRoute raw materials are cheap and easy to getSimple stepsGroup 4/14 element organic compoundsButyrateCombinatorial chemistry
The invention discloses a synthetic method of a carbapenem antibiotic drug intermediate. By using (R)-3-hydroxybutyrate as the raw material, the carbapenem antibiotic drug intermediate 4-AA is prepared. Raw materials for the process are cheap and easily-available and can be purchased in quantity. The synthetic method has simple steps, yield of each step is high, and reactions are simple. By usinga chiral column as the split chiral center, use of a precious metals chiral reducing catalyst is avoided. the synthetic method of the invention has the following advantages: cost is low; yield is high; and reaction conditions are easily available.
Owner:ZHEJIANG GONGSHANG UNIVERSITY +2
Method for preparing spirolactone key intermediate epoxide
PendingCN113563407AEasy to recycleLow raw material costSteroidsBulk chemical productionFluoroboric acidEnvironmental chemistry
The invention provides a method for preparing a key intermediate epoxide of spirolactone, which comprises the following operation steps: dissolving etherate (I) in an organic solvent, adding ionic liquid, trimethyl sulfonium bromide and inorganic alkali liquor, reacting at 10-40 DEG C while stirring to prepare epoxide (II), wherein the ionic liquid is any one of 1-butyl-3-methylimidazolium tetrafluoroborate, 1-methyl-3-methylimidazolium tetrafluoroborate, 1-methyl-3-ethylimidazolium tetrafluoroborate or 1-ethyl-3-ethylimidazolium tetrafluoroborate. The reaction route is as follows: a low-cost inorganic strong base is used for replacing a high-cost organic strong base, the ionic liquid is used for replacing the dimethyl sulfoxide difficult to post-treat, the reaction is finally completed under the simple and easily available conditions, the cost is low, the energy consumption is small, and the environmental pollution is small.
Owner:TIANJIN JINJIN PHARMA
Adapter-modified magneto-optic dual-function contrast agent and preparation method and application thereof
InactiveCN102397566BUniform particle sizeMagnetically stableMicrobiological testing/measurementNMR/MRI constrast preparationsPolyethylene glycolIsothiocyanic acid
The invention discloses an adapter-modified magneto-optic dual-function contrast agent and a preparation method and application thereof. The contrast agent comprises silicon dioxide-coated trimanganese tetroxide nanoparticles, wherein the diameters of trimanganese tetroxide nanoparticles are 6-8 nanometers; the thickness of a silicon dioxide coating layer is 8-12 nanometers; the surface of the silicon dioxide coating layer is provided with an amino group and is coupled with a rhodamine isothiocyanate molecule and dicarboxyl polyethylene glycol through the amino group; and the dicarboxyl polyethylene glycol is connected with an adapter with an amino group. The contrast agent obtained in the invention has high monodispersity, high biocompatibility and targeting property, can be taken as a good T1 magnetic resonance imaging contrast agent, has high targeting property on tumor cells, and has wide application value in the fields of medicaments and biology; and the preparation method provided by the invention has the advantages of very low requirements on equipment, convenient operation process, low prices of need raw materials and nuisanceless byproducts.
Owner:SHANGHAI NORMAL UNIVERSITY
Preparation method of beta-ketone substituted phosphate ester compound
InactiveCN105837625AReasonable designRaw materials are easy to getGroup 5/15 element organic compoundsMANGANESE ACETATEOrganic solvent
The invention provides a preparation method of a beta-ketone substituted phosphate ester compound. The beta-ketone substituted phosphate ester compound is generated through a reaction of initial materials comprising alkenyl azide and phosphite ester in an organic solvent with manganese acetate as an oxidant. The preparation method has the advantages of reasonable design, easily available raw materials, mild reaction conditions, no high temperature reflow, high safety and convenience, and high yield, and allows the yield of most of products to be 70% or above. The preparation method is a method for constructing the beta-ketone substituted phosphate ester compound and having the advantages of simple operation, fastness, mildness and diversification; and the two initial raw materials are obtained through a one-step technology, so reaction raw materials are cheap and can be easily obtained. The general formula (I) of the beta-ketone substituted phosphate ester compound is shown in the description.
Owner:ZHEJIANG UNIV
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