86results about How to "Induced growth" patented technology

A bowel extension device implantable into a body for treatment of short bowel syndrome. The bowel extension device comprises a housing and a displaceable member coupled to the housing. The bowel extension device is configured to apply a tensile force sufficient to promote bowel growth without causing damage to the bowel. In some embodiments, the bowel extension device can be completely contained with the body.

Methods and compositions for treatment, diagnosis, and prevention of a virus comprise administering to a patient antibodies which react with regions of viral proteins and result in neutralization of infectivity and inactivation of functionally essential events in the life cycle of the virus. The antibodies recognize viral epitopes which fail to elicit an immune response in man when encountered through infection or naturally through the environment. In a preferred embodiment, the invention provides compositions and methods useful in the treatment and diagnosis of human immunodeficiency virus (HIV) infections.

The invention relates to a medical alloy material, in particular to a uniformly degradable orthopedic implant magnesium alloy material. The orthopedic implant magnesium alloy material comprises the following components in percentage by weight: 0-5% of Gd, 1-5% of Nd, more than 0-2% of Sr, 0-0.5% of Zn, more than 0-1% of Zr and the balance of Mg. Due to the addition of magnesium alloy elements Gd and Nd, the strength and the corrosion resistance of the magnesium alloy are improved. In addition, a small amount of Gd and Nd are better in bio-safety; Sr has the effect of inducing growth of osteoblasts; Zn is a human necessary micronutrient element, and the ductility and the corrosion resistance of the alloy can be improved due to the addition of the Zn; and Zr has the effects of refining crystal grains and improving the strength and the corrosion resistance of the alloy and can enable the magnesium degrading speed to be more uniform, and no cell toxicity exists after a small amount of Zr is added.

The invention relates to an injectable composite material for bone repair. According to the composite material, biological tissue materials and biological ceramics are organically combined so as to form an injectable medical material with a three-dimensional scaffold function. In the invention, a biological tissue material substrate is micro-fiber with a natural crosslinking structure, is free of additional physical or chemical crosslinking, has good biocompatibility, and can be slowly degraded completely in vivo; and the biological tissue materials and the biological ceramics can be combined in multiple ways. In the composite material, after the biological ceramics serving as a reinforced phase are combined with the biological tissue materials, a favorable template can be provided for bone tissue regeneration in vivo, and bone growth can be effectively induced. The injectable material provided by the invention can be used for seamlessly filling bone defect of any size, and biological agents including bone marrow are added in the process, so that the bioactivity is further enhanced. Therefore, the material can be widely used for bone defect caused by wounds, resection of tumors, osteonecrosis, infection and the like.

The invention relates to an artificial knee joint bone fusion prosthesis. The artificial knee joint bone fusion prosthesis comprises a femur condyle prosthesis, a tibia platform prosthesis and a joint pad, wherein the femur condyle prosthesis comprises a joint surface, a condyle combination surface, a intercondylar combination surface, a positioning body, a femur intramedullary stem and a femur intramedullary extending stem; the tibia platform prosthesis comprises a platform body, a tibia combination surface, a wing plate or a positioning body, a tibia intramedullary stem and a tibia intramedullary extending stem; the femur intramedullary stem, the femur intramedullary extending stem, the tibia intramedullary stem and the tibia intramedullary extending stem are hollow, the surfaces of the intramedullary stems and the extending stems have porous or mesh structure so as to ensure that the hollow parts in the stem body can be communicated with the external part; when in use, autograft or allograft crushed bone particles are filled in the hollow parts of the intramedullary stems and the intramedullary extending stems, and after the external bone tissue fuses and grows together with the crushed bone particles filled in the intramedullary stems, the overall elastic modulus can be very close to that of the human bone, thus reaching the aim of effectively preventing the loose between the artificial knee joint bone fusion prosthesis and the sclerotin for long time.

The invention provides a preparation method of a multifunctional layered joint cartilage support. The multifunctional layered joint cartilage support capable of simulating the biological property andthe mechanical property of natural cartilage is prepared by taking hydrogel as a support material, taking mesenchymal stem cells, cartilage cells and osteoblasts as inducing and developing objects andby adopting a 3D printing technology. The multifunctional layered joint cartilage support can accurately simulate the internal tissue form and the contour of each layer of the natural cartilage and can realize that different layers have different mechanical and biological characteristics. The prepared artificial cartilage support cells are derived from patients, the support serves as a degradablehydrogel material and the rejection reaction after implantation is greatly reduced. Various nutritional substances and growth factors are mixed in the hydrogel support, so that the sustained releaseeffect can be achieved and regulation and control of the growth and development of the artificial cartilage can be realized.

The invention relates to biodegradable Mg-Gd-Zn-Ag-Zr series magnesium alloy and a preparation method thereof in the technical field of medical alloy. The alloy consists of Gd, Zn, Ag, Zr and Mg in percentage by weight: 5-10 percent of Gd, 0.5-3 percent of Zn, 0.1-1 percent of Ag, 0.1-1 percent of Zr and the balance of Mg. Through reasonably designing the alloy elements, a long-period stacking order structure (LPSO structure) is formed in an alloy structure; and with the adoption of the structure, the alloy can be strengthened and toughened, and the corrosion resistance and the local corrosion resistance of the alloy can be improved. Through deformation processing and heat treatment, the strong toughness and the corrosion resistance of the magnesium alloy can be further improved. The magnesium alloy provided by the invention is uniformly corroded in simulated body fluid, so that the overall failure of an implant material due to local corrosion is avoided, and no obvious cytotoxicity exists. The biodegradable Mg-Gd-Zn-Ag-Zr series magnesium alloy can be used as a bone plate, a bone nail and other fixing and implant materials in the orthopeadic surgery.

The invention discloses a method for preparing ordered ferriferrous oxide / chitosan nanometre composite material comprising the following steps, making chitosan solution from chitosan powder with thin acid solution, charging FeCl2 and FeCl3 solution into the chitosan solution, forming ferriferrous oxide / chitosan precursor solution, loading the precursor solution into a mould with a layer of pure chitosan film internally, placing into freeze liquid, removing the mould and applying magnetic field onto the two ends of the gel composite material for material forming, flushing to neutral with distilled water and drying.

The invention relates to an acetabular bone deformity filler which comprises a bone deformity filler, a screw hole, reinforcing ribs and a reinforcing plate and is made into a three-dimensional porous dictyosome structure by adopting medical metals or biological ceramics. The surface and the interior of the three-dimensional porous dictyosome are provided with a plurality of mutually communicated pore canals, the acetabular bone deformity filler is provided with a screw hole in a suitable position and also provided with a bone-planting hole for containing bone-planting particles or bone meal in a suitable position, all or partial surface of the acetabular bone deformity filler is provided with a hydroxyapatite coating, and the acetabular bone deformity filler can be effectively prevented from loosening for a long time when external osseous tissue permeates and grows in the three-dimensional porous dictyosome and melts and grows with the bone-planting particles or the bone meal filled in the bone-planting hole into a whole after operational planting.

The present invention discloses a kind absorptive bone hemostatic for surgical and orthopedic operation. The absorptive bone hemostatic includes mainly chitosan or modified chitosan 20-95 weight portions, konjaku glucomannan or carboxymethyl modified konjaku glucomannan 5-80 weight portions, and water in 50-500 % of total solid matter. It is prepared through mixing powder or water solution of the material. The absorptive bone hemostatic has simple operation, good compatibility, no irritation and inflammation reaction, and can induce bone growth.

Embodiments of a mask for sequential lateral solidification are disclosed herein. In some embodiments, a mask of the present disclosure comprises a transmission region including a first slit column having a plurality of first slits separated from one another by a predetermined interval, and a second slit column having a plurality of second slits separated from one another by a predetermined interval and disposed adjacent to and offset from the first slit column. An irradiated laser beam is substantially completely transmitted through the transmission region. In some embodiments, the mask includes a semi-transmission region including a first opening pattern disposed at least partially between adjacent first slits and having a plurality of first openings formed into a desired shape, and a second opening pattern disposed at least partially between adjacent second slits and having a plurality of second opening formed into a desired shape. A portion of less than all of the laser beam is transmitted through the semi-transmission region. A method of performing the sequential lateral solidification using the mask is also disclosed herein.

The present invention discloses a planting method for high-yielding rice, and the planting method includes the following steps: A, planting broad beans in rice fields, harvesting the broad beans, conducting green manuring and water retting on the harvested broad beans, and applying base fertilizers to the rice fields; and conducting water control on rice seedlings with a seedling age of 15-20 days and a seedling acclimatization for 2-3 days; B, conducting rotary tillage, ridge separating and irrigation on the rice fields, and transplanting the rice seedlings; C, topdressing the rice seedlings with compound fertilizers to promote rice tillering after roots and stems of the rice seedlings are living; D, maintaining a water level of the rice fields at 3-5 cm during the rice tillering stage, topdressing the rice seedlings with urea, potassium chloride and calcium superphosphate, topdressing the rice with N-P-K compound fertilizers with an amount of 80-110 kg / mu and spraying biological pesticides when the rice is in the heading stage; topdressing the rice with the compound fertilizers mentioned in step C with an amount of 25-40 kg / mu when the rice is in the irrigation stage; and cutting off the water supply and drying the rice fields 7-10 days before rice maturity, and harvesting the mature rice. The planting method makes the rice high in yield, good in quality, and less in pesticide residues.

A bowel extension device implantable into a body for treatment of short bowel syndrome. The bowel extension device comprises a housing and a displaceable member coupled to the housing. The bowel extension device is configured to apply a tensile force sufficient to promote bowel growth without causing damage to the bowel. In some embodiments, the bowel extension device can be completely contained with the body.

The invention relates to an artificial hip stem with low elasticity modulus, which comprises a head part, a neck part and a stem body, wherein the stem body is designed into a hollow structure, and the surface of the stem body is provided with a plurality of holes or a mesh structure to make sure that the hollow part inside the stem body is kept communicating with the outside. Before implantation, the hollow part of the stem body is filled with autologous or xenogenous crushed bone particles; after external bone tissues grow with the crushed bone particles filled into the stem body into a whole, the total elasticity modulus can be approximate to that of human bone so as to lastingly and effectively prevent the loose action between the artificial hip stem and sclerotin.

The invention relates to a bone grafting filler metal particle body which is used for bone defect filling. Bone grafting holes for containing grafted broken bone particles or bone paste are formed on the bone grafting filler metal particle body and are in interpenetrated connection with one another, and micropores which are communicated with one another are formed on the external surface of the particle body and the internal surfaces of the bone grafting holes. When surgery is performed, a certain amount of bone grafting filler metal particle bodies is mixed with autogenous bones or bone blocks, bone particles and bone paste of allogenic bones according to the requirement for bone defect filling, the fillers of autogenous bones or the allogenic bones can be partially replaced in an occupation manner, bone cells and microvessels grow into the insides of the bone grafting filler metal particle bodies during the recovery process of a patient, and a fusion embedded bone repairing body with biological activity can be formed.

The invention discloses a traditional Chinese medicine cancer toxin prescription for treating liver cancer and application thereof in the preparation of medicaments for resisting liver cancer. The cancer toxin prescription is prepared in accordance with the cancer toxin theory proposed by traditional Chinese medicine master Professor Zhou Zhongying, and is prepared from hedyotidis herba, muscardine silkworm, centipede, akebia fruit, pseudostellaria root, dwarf lilyturf root and rhizoma pleionis according to a certain weight ratio. The prescription has the main functions of eliminating pathogens, eliminating cancer and detoxicating and the auxiliary function of strengthening healthy qi. By using mice with liver cancer H22 transplantation tumor as materials, the pharmacological experiment result shows the cancer resistance effect of the cancer toxin prescription: the tumor inhibition rates of a low-dose group, an intermediate-dose group and a high-dose group are respectively 24.5%, 42.8% and 21.1%, thereby showing the effect of inhibiting the growth of H22 tumor mass; the tumor mass cell apoptosis rates of the low-dose group, the intermediate-dose group and the high-dose group are respectively 47.16%, 60.52% and 57.59%, thereby showing the effect of inducing tumor cells to die; and the cancer toxin prescription can block the high expression of TLR4, block the MyD88 dependent pathway of TLR4 intracellular signal transduction and inhibit the expression of downstream NF-kB proteins. Experiment shows that the cancer toxin prescription can be used for preparing medicaments for resisting liver cancer.

The present invention relates to a surface porous bioactive implant and a preparation method thereof, a microporous implant with the aperture diameter of 10-250 mum is prepared from pure titanium powder or titanium alloy powder by 3D printing technology; the microporous implant is degreased and cleaned; 5mol / L NaOH is used for alkali heat treatment at 80 DEG C, and after sintering, the furnace cooling is performed; the obtained implant is placed in the simulated body fluid for mineralization at the processing temperature of 37.5 DEG C for 1-10 days to form a hydroxyapatite coating with the thickness of 0.01 to 20 mum on the surface; finally the obtained implant is ultrasonically cleaned for 5min by purified water, after flushing, the cleaning and packaging are performed; the complicated preparation process problem is solved, the three dimensional printing technology is simple, and the aperture diameter is adjustable and precise.

The invention relates to a method for preparing a carbon catalyst based on carbon template-induced Fe-N growth and the carbon catalyst. The preparation method of the catalyst comprises the following steps of 1) dispersing a carbon material into a solvent A, and then performing wet ball milling, freezing and drying to obtain a carbon template; 2) dissolving a Fe compound and an N compound into a solvent B, and then adding the carbon template, performing uniform mixing and drying to obtain a catalyst precursor; and 3) performing high-temperature pyrolysis on the catalyst precursor in gas atmosphere to obtain the Fe and N co-doped carbon catalyst. Compared with the prior art, the preparation method disclosed in the invention can suppress generation of non-active or weak active metal Fe particles, Fe carbide and the like by virtue of introduction of the carbon template, so as to promote conversion of the metal Fe particles, Fe carbide and the like to strong active Fe-N<x> species to inducegrowth of Fe-N<x> strong active sites and the like; and in addition, interaction can be generated between the carbon template and the Fe-N<x> active sites and the like, so that the electronic structure can be regulated and enhancement of the inherent activity can be improved.

A bowel extension device implantable into a body for treatment of short bowel syndrome. The bowel extension device comprises a housing and a displaceable member coupled to the housing. The bowel extension device is configured to apply a tensile force sufficient to promote bowel growth without causing damage to the bowel. In some embodiments, the bowel extension device can be completely contained with the body.

The invention relates to periodontitis gel containing hyaluronic acid and a preparation method thereof. The periodontitis gel is prepared from the following ingredients in mass percent: 0.1% to 1.5% of sodium hyaluronate derivative, 0.05% to 1.0% of enzyme-digested oligomerized sodium hyaluronate, 5% to 15% of glycerinum, 1.5% to 4.5% of honeysuckle flower aqueous extractive, 0.02% to 0.2% of recombinant human bone morphogenetic protein-2 (rhBMP-2), 0.02% to 0.2% of base fibroblast growth factor (b-FGF), 0.02% to 0.04% of pentanediol, 0.02% to 0.04% of octylene glycol, 0.1% to 0.3% of methylparaben and purified water added to 100%. The gel disclosed by the invention can be applied to treating gingivitis and periodonititis and has an obvious treating effect.

The invention provides tetrakaidecahedron metal hydroxystannate and a preparation method and application thereof. The molecular formula of the tetrakaidecahedron metal hydroxystannate is MSn(OH)6, wherein M is Ca, Mg, Co, Ni, Mn or Cu. The preparation method includes: mixing equal-mole tin salt solution and metal salt solution, stirring, adding regulator, stirring for 10 minutes to 3 hours, dropwisely adding alkaline solution, and transferring to a hydrothermal kettle for reaction for 5-24 hours to obtain the tetrakaidecahedron metal hydroxystannate, wherein the reaction temperature is 25-120 DEG C. The tetrakaidecahedron metal hydroxystannate is widely applicable to the technical field of photocatalysis, and the light degradation effect of tetrakaidecahedron light is better than that of hexahedron light during methylene blue degradation using photocatalysis.

The invention provides a preparation method of a bone tissue engineering porous ceramics scaffold, belongs to the technical field of medical apparatus and instruments, and is capable of effectively solving the uniform distribution problem of drug carrying chitosan microspheres coating the surface of the bone tissue engineering porous ceramics scaffold. The preparation method comprises the steps of firstly preparing a porous scaffold, then preparing a drug carrying microspheres, and then preparing a ceramics scaffold coated with alginic acid. After obtaining the ceramics scaffold of which the surface is coated with the alginic acid, the drug carrying microspheres is needed to be combined with the ceramics scaffold: uniformly dispersing the prepared drug carrying microspheres into a centrifuge tube filled with deionized water, soaking the ceramics scaffold coated with the alginic acid into the centrifuge tube filled with the drug carrying microspheres, placing at the temperature of 37 DEG C, vibrating in a constant-temperature vibration box with the rotation speed of 60 to 120r / min for 1 to 3h, taking out the ceramics scaffold, repeatedly washing by using the deionized water, and then performing vacuum drying to obtain the bone tissue engineering porous ceramics scaffold which is coated with the alginic acid and provided with the uniformly-distributed drug carrying microspheres. The bone tissue engineering porous ceramics scaffold is mainly used for human bone tissue repair.

The invention discloses application of an extracellular matrix freeze-drying powder. The extracellular matrix freeze-drying powder is prepared from fresh mammal tissues by rinsing, disinfecting, degreasing, rinsing, cell removal, cleaning, pulping, extracting and freeze-drying. The extracellular matrix freeze-drying powder has the advantages that the multiple active matters of polytype collagen, proteoglycan, growth factors and the like in the animal tissues are reserved; the multiple biological activities are realized, the biocompatibility is good, and the tissue regeneration is promoted; theanti-oxidizing, repair and aging-resisting effects are realized, and the proliferation, transfer and differentiation of the cells are induced; the extracellular matrix freeze-drying powder can be used as the structure support, and the filling function is realized.

The invention provides a method for improving the osteogenesis ability of mesenchymal stem cells, which comprises the following steps: inoculating the mesenchymal stem cells into an alpha-MEM culturemedium containing 10% of fetal calf serum, culturing, digesting and subculturing by 0.2% of pancreatin when the fusion degree of the mesenchymal stem cells is 80-85%, inoculating the obtained mesenchymal stem cells into an alpha-MEM culture medium containing 10% of fetal calf serum for culture, and adding osteogenesis induction liquid and a metformin aqueous solution for induction when the densityof the mesenchymal stem cells is greater than 90% for induction for 14-21 days. The metformin acts on the mesenchymal stem cells, alizarin red staining results show that the metformin can significantly improve the calcium mineralization nodule degree of the cells, and it is indicated that the metformin has a significant induction effect on mesenchymal stem cell osteogenic differentiation, the metformin can significantly improve the expression of the mesenchymal stem cell osteogenic differentiation related genes SIRT1, ALP, COL1A1, RUNX2 and BGLAP, and the improvement of the osteogenic differentiation capacity of the mesenchymal stem cells is of great significance to stem cell transplantation and bone biology research.

The invention discloses multifunctional injectable hydrogel for tumor photo-thermal treatment and bone tissue repair and a preparation method, and belongs to the field of biomedical materials. The preparation method comprises the following steps of firstly, synthesizing micro-nano carbon spheres by adopting a hydrothermal carbonization method; secondly, adding the micro-nano carbon spheres into achitosan solution, and performing uniform stirring to obtain a solution A; thirdly, simultaneously dissolving beta-sodium glycerophosphate and sodium hyaluronate in deionized water, and performing sufficient stirring to obtain a solution B; and finally, in an ice bath environment, adding the solution B into the solution A, uniformly stirring the solutions, and performing sterilizing and disinfection for 24 hours by using an ultraviolet lamp to obtain the injectable composite hydrogel. The injectable hydrogel has good biocompatibility; the injectable hydrogel is in a liquid state at the room temperature, can be directly injected into a bone tumor focus, and can rapidly form gel in situ in an environment with the body temperature of 37 DEG C, so that effective fixation of a photothermal agent and rapid filling of bone defects are realized; and bone tumor cells can be killed through local photo-thermal treatment, meanwhile bone tissue repair can be effectively promoted, and all-dimensional treatment of bone tumors is achieved.

The invention discloses an anisotropic magnetoresistive permalloy buffer layer preparation method. The method comprises the steps that a substrate which is thoroughly cleaned is put into a vacuum cavity, argon gas is provided in the whole process, a buffer layer is deposited by adopting the pulse radio frequency as a sputtering power source, then a NiFe layer is deposited, and finally a covering layer is deposited. The pulse radio frequency technology is adopted, power is supplied to a target gun at intervals during thin film deposition, time is provided for migration of material atoms on the surface of the substrate due to pulse radio frequency interval deposition, and the thin film flatness is improved, so that the crystalline degree of the thin film is enhanced, and the material AMR value is increased; by means of the pulse radio frequency deposition technology, the deposition atoms can sufficiently migrate on the surface of the substrate, the surface flatness of the buffer layer is improved, growth of the NiFe thin film structure can be better induced at normal temperature, and the crystalline grain diameter is increased, so that the permalloy thin film AMR value is increased, the coercive force is lowered, and the thin film sensitivity becomes better.

The present invention discloses the method of preparing natural biological pearl coating on the surface of metal tooth implant. The metal tooth implant is implanted inside pearl shell and cultured for one period to form one layer of natural biological coating comprising calcium carbonate and organic matter on the surface of metal tooth implant. The coating is hard and firmly combined with the metal substrate and has excellent bone tissue compatibility of natural pearl essence.

Embodiments of a mask for sequential lateral solidification are disclosed herein. In some embodiments, a mask of the present disclosure comprises a transmission region including a first slit column having a plurality of first slits separated from one another by a predetermined interval, and a second slit column having a plurality of second slits separated from one another by a predetermined interval and disposed adjacent to and offset from the first slit column. An irradiated laser beam is substantially completely transmitted through the transmission region. In some embodiments, the mask includes a semi-transmission region including a first opening pattern disposed at least partially between adjacent first slits and having a plurality of first openings formed into a desired shape, and a second opening pattern disposed at least partially between adjacent second slits and having a plurality of second opening formed into a desired shape. A portion of less than all of the laser beam is transmitted through the semi-transmission region. A method of performing the sequential lateral solidification using the mask is also disclosed herein.

The invention discloses a composite polypropylene mesh. The composite polypropylene mesh is bonded by a polypropylene mesh and a fibroblast growth factor through polydopamine. In the premise condition of not changing the mechanical strength and the surface structure of the original polypropylene mesh, the fibroblast growth factor is grafted on the surface of the polydopamine after the polydopamine is grafted on the surface of the polypropylene mesh, and the composite mesh separation phenomenon cannot be generated. Simultaneously the fibroblast growth factor is hard to degrade in the body, the fibroblast growth can be induced and then the fascia reconstruction is induced.

The invention discloses a hair loss prevention shampoo and a making method thereof. The hair loss prevention shampoo comprises the following raw materials: hair loss prevention shampoo traditional Chinese medicines, lauryl polyoxyethylene ether ammonium sulfate, dodecyl alcohol ether sodium sulfate, hexadecanamide propyl glycine betaine, PEG-80 sorbitan laurate, a skin penetration enhancer, an essence, a nucleic acid, a pH adjuster and water. With a natural medicinal plant formula, and with the combination of active components of five traditional Chinese medicine essences, the hair loss prevention shampoo disclosed by the invention takes the special effects of traditional Chinese herbal medicines into play, hair follicle transdermal absorption of the shampoo can be rapidly achieved, the shampoo does not stimulate hair, does not damage the hair, can be rapidly absorbed into hair follicle, is capable of promoting scalp blood circulation and keeping life activity of hair follicle, has theadvantages of growing hair and continuously treating hair loss, and is applicable to people of various types of hair loss and particularly people suffering from medium and serious hair loss.