The invention relates to a large-wall-thickness X52MS acid-resistant pipeline steel plate produced by an LF-RH refining process. The steel plate is characterized by being manufactured from the following chemical component percentage by weight: 0.03%-0.07% of C, 0.2%-0.4% of Si, 1.0%-1.4% of Mn, 0.02%-0.04% of Al, 0.02%-0.05% of Nb, less than or equal to 0.02% of V, 0.004%-0.012% of Ti, 0.1%-0.4% of Cr, 0.1%-0.2% of Mo, less than or equal to 0.0005% of B, less than or equal to 0.012% of P, less than or equal to 0.001% of S, less than or equal to 0.005% of [N], less than or equal to 0.005% of [O], less than or equal to 0.0015% of [H] and the balance being Fe and inevitable impurities, wherein the cold crack
sensitivity coefficient Pcm is less than or equal to 0.19. The manufacturing method comprises the sequential steps of KR molten iron pretreatment, converter
smelting, LF and RH refining, plate blank
continuous casting, plate blank heating, rough rolling, intermediate blank cooling, finish rolling, ACC cooling and the like. The manufactured steel plate has thickness being 35.1-44.2 mm, yield strength being 380-440 MPa, tensile strength being 490-570 MPa, and elongation being greater than or equal to 33%,
yield ratio being less than or equal to 0.09; an average shear plane ratio of drop hammer under the temperature of minus 5 DEG C is 85% or more; and the large-wall-thickness X52MS pipeline steel can meet the requirement of being used in an acidic environment, and has good HIC resistance and low-temperature
toughness.