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46results about How to "High tumor inhibition rate" patented technology
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Preparation method and application of metal organic framework drug carrier system based on cytosine arabinoside micromolecule prodrug
ActiveCN108619511ASolve the shortcomings of being easily inactivated by metabolismImprove stabilityOrganic active ingredientsPowder deliveryMetal-organic frameworkIn vivo
The invention discloses a preparation method and application of metal organic framework drug carrier system based on drug cytosine arabinoside micromolecule prodrug. The preparation method disclosed by the invention comprises the steps: choosing molecules which can generate coordination reaction with metal ions to be covalently combined with cytosine arabinoside to synthesize novel multifunctionalmicromolecule prodrug; carrying the prodrug on the metal organic framework through a simple environment-friendly one-step entrapment method to form medicine carrying nanoparticles; centrifuging, washing and drying to obtain a cytosine arabinoside micromolecule prodrug carrying MOF intravenous injection preparation. Taking synthesized Ara-IR820@ZIF-8 as an example, a mouse in-vivo antitumor pharmacological result shows that HA / Ara-IR820@ZIF-8 nano water solution has a good antitumor effect and lower system toxicity. The intravenous injection preparation has the advantages of high medicine carrying amount, simple and economic preparation process, batch production, small toxicity, good safety and wide application prospect in achieving high medicine carrying amount of the cytosine arabinosidein the metal organic framework and applying intravenous injection dosage to treat solid tumors.
Owner:SHANDONG UNIV
Application of apatinib and anti-PD-1 antibody combination to preparation of colon cancer medicines
InactiveCN106963948AHigh tumor inhibition rateIncreased area of necrosisOrganic active ingredientsAntibody ingredientsWilms' tumorCancer research
The invention discloses application of apatinib and anti-PD-1 antibody combination to preparation of colon cancer medicines. The colon cancer is treated through combined medication of apatinib and an anti-PD-1 antibody; through experiments, the tumor inhibition rate of apatinib and anti-PD-1 antibody combination is 53.97 percent, the tumor inhibition rate is increased by 40.4 percent as compared with that of a single apatinib group (53.97 percent vs 13.57 percent, P is less than 0.05, Mann-Whitneytest), and the tumor inhibition rate is increased by 23.17 percent as compared with that of a single anti-PD-1 antibody group (53.97 percent vs 13.57 percent, P is less than 0.05, Mann-Whitneytest) (the tumor inhibition rate is equal to 1-expreiment group tumor volume / control group tumor volume). After the apatinib and the anti-PD-1 antibody are combined, the tumor necrosis area can be obviously increased as compared with that of single groups.
Owner:顾艳宏
Extraction method of land slug and anti-lung cancer application of land slug
ActiveCN103610699AHighlight the role and effectSignificant tumor suppressor effectRespiratory disorderAntineoplastic agentsWater bathsHigh concentration
The invention discloses an extraction method of a land slug and an anti-lung cancer application of the land slug. The extraction method comprises the following steps: (1) carrying out vacuum freeze-drying on the land slug, adding purified water and then carrying out water bath agitation, adding a high-concentration ethanol solution, evenly agitating until the ethanol concentration is 60-70%, standing and then carrying out solid-liquid separation; (2) clarifying and intercepting the liquid obtained in the step (1) by adopting an inorganic ceramic membrane system, so as to obtain total clear liquid of the land slug; (3) concentrating the total clear liquid of the land slug obtained in the step (2) by a reverse osmosis membrane; and (4) concentrating and drying ultra-filtrate obtained in the step (3), so as to obtain water-soluble land slug powder. The molecular weight of the land slug powder obtained by the method is concentrated between 20,000 and 30,000, and has a significant antitumor effect; the tumor control rate is higher than that of cinobufagin and close to that of cyclophosphamide. The water-soluble land slug powder disclosed by the invention is used for treating a lung cancer, and is efficient and low-toxicity.
Owner:GUANGZHOU HANFANG PHARMA
Metal fullerol and its pharmaceutical use for inhibiting tumour growth
ActiveCN1935812AReduce dosageLow toxicityHydroxy compound active ingredientsGroup 3/13 element organic compoundsAbnormal tissue growthRare earth
The invention relates to metal fullerols and its application in preparing inhibition tumor medicine. Its general formula is M@C2m(OH)x, which M can be Gd, La, etc, m=41 or 30, x is not less than 10 and less than 50; it also can be M@C2mOxHy. Compared with clinic common using cyclophosphamide, cisplatin, paclitaxel etc, the metal fullerols M@C2m(OH)x or M@C2mOxHy has the advantages of little use level, low toxicity, high tumor inhibition ratio.
Owner:INST OF HIGH ENERGY PHYSICS CHINESE ACADEMY OF SCI
Thermosensitive injectable hydrogel for drug delivery
ActiveUS20150366975A1Efficient Growth InhibitionGood curative effectBiocideAerosol deliveryPolyethylene oxideMedicine
The invention develops a developed a thermosensitive injectable hydrogel based on HA and a copolymer of polyethylene oxide (PEO) and polypropylene oxide (PPO), which has a gel formation temperature from 30° C. to 37° C. The thermosensitive injectable hydrogel of the invention provides a potential drug delivery system that can increase therapeutic efficacy of the drug.
Owner:TAIPEI MEDICAL UNIV
Vincristine-reversal agent composite nano-granule and preparation method and use thereof
InactiveCN101361714AResidue reductionHigh tumor inhibition ratePowder deliveryAntineoplastic agentsMedicineMortality rate
The invention relates to a vincristine-reversion agent compound nano particle, a preparation thereof and applications, belonging to the medicine field. A first technical problem to be solved by the invention is: overcoming the phenomena of multidrug resistance MDR of various tumor cells to the vincristine, namely, the vincristine and the reversion agent are wrapped and carried in a PLGA in a compound way, for preparing the nano particles. With the purposes of obtaining the smaller-diameter nano particles and reducing the vestigital of the surface active agent, F68 and TPGS are adopted as the surface active agent; compared with PVA, the TPGS and the F68 can obviously increase the mortality of drug-resistant breast cancer cells (p is smaller than 0.05); and the tumor-inhibition rate of the TPGS is obviously higher than that of the F68.
Owner:SICHUAN UNIV
PH-sensitive doxorubicin hydrochloride loaded silver nano-cluster hydrogel and application thereof
ActiveCN105193706ANo side effectsSlow release rateOrganic active ingredientsAerosol deliveryCentrifugationCardiac toxicity
The invention provides pH-sensitive doxorubicin hydrochloride loaded silver nano-cluster hydrogel. A preparation method of the silver nano-cluster hydrogel comprises the following steps: (1), an AgNO3 solution is prepared, placed in a microwave reactor, stirred and heated, a cysteine solution is added dropwise, and a silver nano-cluster dispersing agent is prepared through reaction; (2), a citric acid solution is added to the silver nano-cluster dispersing agent, the mixture is placed on a small shaking table and subjected to ultraviolet irradiation, an NaHCO3 solution is added to regulate pH after the solution is transparent, high-speed centrifugation is performed, doxorubicin hydrochloride powder is added, the mixture is placed in a high-pressure reactor, nitrogen is introduced, the pressure and the temperature in the reactor are adjusted, red and clear jelly, namely, the pH-sensitive doxorubicin hydrochloride loaded silver nano-cluster hydrogel, is obtained through reaction. The silver nano-cluster hydrogel is taken as a carrier to coat doxorubicin hydrochloride and is injected to a tumor position through orthotopic injection, the pH of the tumor position is responded, so that slow drug release is realized, the tumor inhibition rate is increased, and cardiac toxicity is reduced.
Owner:JIANGNAN UNIV
Method for activation of prodrug by tumor targeting bacteria and use thereof
ActiveCN102940651AAchieve activationImprove anti-tumor efficiencyBacteria material medical ingredientsGenetic material ingredientsTumor targetEnzyme Gene
The invention belongs to the field of biotechnology and especially relates to a method for activation of a prodrug by tumor targeting bacteria and a use thereof. The method utilizes tumor targeting bacteria as natural prodrug activation tools; and the tumor targeting bacteria can realize constitutive expression of an endogenic prodrug activation enzyme gene thereby specifically activate a prodrug in tumor tissue and thus the activated prodrug can produce tumor-resistant effects. The method can be used for tumor treatment.
Owner:NANJING UNIV
Tabletted sweets containing sulforaphen as well as preparation method and application of tabletted sweets
InactiveCN105410302AAvoid degradationFix stability issuesConfectionerySweetmeatsMaltodextrinMagnesium Sterate
The invention discloses tabletted sweets containing sulforaphen. The tabletted sweets comprise the following raw materials in parts by weight: 200-250 parts of sulforaphen crude extracts, 150-200 parts of maltodextrin, 30-50 parts of microcrystalline cellulose, 3-5 parts of magnesium stearate and 0.5-1 part of a sweetening agent. The invention further discloses a preparation method of the tabletted sweets and application of the tabletted sweets in the respect of restraining tumors. The prepared tabletted sweets disclosed by the invention can prevent the sulforaphen from being degraded, the problem of poor stability of the sulforaphen is effectively solved, and the quality guarantee period of the tabletted sweets under the storage conditions of being shadowy, cool and dry is 24 months. Because the tabletted sweets contain the sulforaphen, the tabletted sweets have a high tumor restraining rate. The tableted sweets can also effectively solve the problem that at present, sulforaphen products in the market are supplied rarely.
Owner:GUANGZHOU LIUSHUN BIO TEC CO LTD
Long-circulation irinotecan lipidosome composition and preparation method thereof
InactiveCN103830182AHas a long cycle effectHigh tumor inhibition rateOrganic active ingredientsPowder deliverySide effectCholesterol
The invention belongs to the field of medicine preparations, which particularly relates to a long-circulation irinotecan lipidosome composition. The long-circulation irinotecan lipidosome composition is prepared from the following components in parts by weight: 1 part of irinotecan, 2 to 4 parts of hydrogenated soy phosphatidylcholine or distearoyl lecithin, 0.5 to 1.5 parts of cholesterol, 0.4 to 1.2 parts of phosphatidylethanolamine pegol and 0.0104 to 0.051 part of metal-chelator. The invention further discloses a preparation method of the long-circulation irinotecan lipidosome composition and an application of the long-circulation irinotecan lipidosome composition prepared into an irinotecan lipidosome composition injection. According to the irinotecan lipidosome composition and the preparation method thereof, the medicine loading ratio of the irinotecan is greatly improved and the encapsulation efficiency is greater than 99.5%, so that the toxic and side effect of the medicine which is not encapsulated can be obviously reduced; the content of relevant substances is lower than 0.5% and the limit of various toxic impurities is lower than 0.1%, so that the safety of the composition is obviously improved; and the composition is uniform in granularity distribution and good in stability.
Owner:JIANGSU AOSAIKANG PHARMA CO LTD
Medicine for treating and/or preventing cancer and application
PendingCN111298111AImprove anti-tumor effectHigh killing efficiencyAntibody ingredientsImmunological disordersCancer preventionAntiendomysial antibodies
The invention relates to a medicine for treating and / or preventing cancer and an application. The medicine of the invention includes a recombinant MUC1-MBP fusion protein vaccine and a PD-1 antibody.The medicine is expected to break an immune tolerance state of a tumor microenvironment in vivo and enhance the MUC1 specific anti-tumor immune response, and is expected to completely clear tumors tobring gospel to the majority of cancer patients.
Owner:长春康悦生物科技有限公司
Probiotic fermented traditional Chinese medicine compound composition for treating liver cancer and preparation and detection methods thereof
ActiveCN105749154AGreat tasteEnhance physical fitnessComponent separationFungi medical ingredientsTreatment effectIrritation
The invention discloses a probiotic fermented traditional Chinese medicine compound composition for treating liver cancer and preparation and detection methods thereof. The preparation method includes: performing water extraction on traditional Chinese medicine compound medicinal materials; adding nutrient and inorganic salt different in proportion; sterilizing at high temperature, and performing compound intestinal tract probiotic fermentation; stabilizing to obtain the probiotic fermented traditional Chinese medicine compound composition. The traditional Chinese medicine compound medicinal materials include Radix bupleuri, Radix scutellariae, Radix ginseng rubra, Herba hyperici japonici, string stonecrop herb, roasted turtle shell, root of red-rooted salvia, selfheal, raw oyster, Rhizoma corydalis, Radix curcuma piece, polyporus umbellatus and Radix Glycyrrhizae Preparata.The invention further discloses an identification method and a detection method of the probiotic fermented traditional Chinese medicine compound composition. Experiments show that treatment effect of traditional Chinese medicine extract can be improved remarkably, tumor inhibition rate can be increased, and the probiotic fermented traditional Chinese medicine compound composition has remarkable effect on inhibiting liver tumor growth. Taste of the traditional Chinese medicine compound extract can be improved remarkably, irritation of the traditional Chinese medicine extract to intestines and stomach can be reduced, and appetite and physique of patients can be improved.
Owner:SANZHU FUER PHARMA
Application of recombinant ganoderma lucidum immunomodulatory protein rLZ-8 in treating lung cancer, laryngocarcinoma and brain glioma
InactiveCN104043105AConvenient treatmentProlong survival timePeptide/protein ingredientsAntineoplastic agentsOncologyGanoderma lucidum
The invention relates to an application of recombinant ganoderma lucidum immunomodulatory protein rLZ-8 in treating lung cancer, laryngocarcinoma and brain glioma. According to the invention, the in-vivo anti-tumor effect of the rLZ-8 is researched by respectively building a lung cancer mice model by virtue of a caudal vein injection method and building a laryngocarcinoma and brain glioma nude mice animal model by virtue of a subcutaneous transplantation tumor method; a treatment result indicates that the rLZ-8 achieves an obvious anti-tumor effect on the lung cancer, the laryngocarcinoma and the brain glioma.
Owner:张喜田 +1
Composite magnetic nanoparticles for targeted therapy of liver cancer and preparation method thereof
InactiveCN103611168ADoes not lead to conversionEfficient conversionPowder deliveryGenetic material ingredientsMagnetite NanoparticlesTherapeutic effect
The invention relates to composite magnetic nanoparticles for targeted therapy of liver cancer and a preparation method thereof. The method comprises the following steps: respectively preparing recombinant eukaryon expression plasmid p[HRE]AFP-p53 and polyethyleneimine-modified ferroferric oxide magnetic nanoparticles, evenly mixing the recombinant eukaryon expression plasmid p[HRE]AFP-p53 and polyethyleneimine-modified ferroferric oxide magnetic nanoparticles in a mass ratio of 2:1-16:1, and incubating for 30 minutes to obtain the p[HRE]AFP-p53 / polyethyleneimine ferroferric oxide magnetic nanoparticle compound. The compound prepared by the method is used for combination of targeted gene therapy of liver cancer and magnetic fluid thermotherapy, and has specific therapeutic effect for liver cancer in in-vivo and in-vitro therapeutic tests.
Owner:SOUTHEAST UNIV
Rare earth-DNA photo-thermal hydrogel for injection as well as preparation method and application thereof
ActiveCN111888324AEfficient photothermal therapy effectGood biocompatibilityEnergy modified materialsAerosol deliveryPhysicsChemistry
The invention provides rare earth-DNA photo-thermal hydrogel for injection. The hydrogel comprises DNA molecules with negative charges and a rare earth-based nano material with positive charges; and the rare earth-based nano material with the positive charges is UCNP-Au. The DNA molecules and the rare earth-based nano material form a hydrogel material with injectability, efficient photothermal therapy effect and biocompatibility under the action of physical winding, hydrogen bonds and electrostatic force. Experimental results show that the photo-thermal efficiency of the injectable rare earth-DNA photo-thermal hydrogel disclosed by the invention can reach 42.67%. In addition, the tumor inhibition rate is increased, so that the recurrence and metastasis probability of tumors is reduced. Toxic and side effects of medicines on normal tissues in the treatment process are reduced through a paratumoral injection means. Moreover, the degradation of the photo-thermal hydrogel in any time period can be realized by regulating and controlling the ratio of the DNA molecules to the rare earth-based nano material. The hydrogel is simple and rapid to operate and low in tumor recurrence and metastasis probability.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Pharmaceutical composition for treating tumor and preparation method and application thereof
ActiveCN106511414AHigh tumor inhibition rateGood antitumor activityAmphibian material medical ingredientsAntineoplastic agentsDrugVenenum bufonis
The present invention provides a pharmaceutical composition for treating tumor and a preparation method thereof, wherein the pharmaceutical composition is prepared from Chinese Angelica and venenum bufonis. The pharmaceutical composition can significantly improve the tumor inhibition rate, and has significantly-improved antitumor activity compared with Antike capsule made from Chinese Angelica and Toad skin. The pharmaceutical composition is suitable for patients with advanced cancer, can be used as an antitumor adjuvant drug, can improve clinical symptoms and improves the quality of life.
Owner:长春雷允上药业有限公司
Natural small molecule co-assembled nano-drug delivery system as well as preparation method and application thereof
PendingCN111632032ADoes not require complicated chemical synthesis processComplex chemical synthesis processOrganic active ingredientsPowder deliveryUrsolic acidPharmacology
The invention discloses a natural small molecule co-assembled nano-drug delivery system as well as a preparation method and application thereof. The natural small molecule co-assembled nano-drug delivery system is a nano-particle formed by co-assembling two or more than two of oleanolic acid, ursolic acid, glycyrrhetinic acid, betulinic acid, betulin, liquidambaric acid, lupeol, paclitaxel, rheinic acid and catechinic. The original self-assembly morphology of a compound can be changed, nanoparticles with different morphologies and sizes are prepared, and the problem that the morphology of compounds is not suitable for intravenous injection is solved. The nano-drug delivery system disclosed by the invention has one or more pharmacological activities, the compounds forming the nano-drug delivery system play a synergistic anti-tumor role through different mechanisms, and the system has health-care functions and can be used for improving the oxidation resistance of an organism.
Owner:HARBIN INST OF TECH
Preparation method and application of NK cell synergistic stimulation polymer micelle
ActiveCN113209019APromote apoptosisIncrease particle sizePeptide/protein ingredientsPharmaceutical non-active ingredientsBiophysicsBiomedical engineering
The invention discloses a preparation method and application of NK cell synergistic stimulation polymer micelle. According to the preparation method of the NK cell synergistic stimulation polymer micelle, IL-15 and IL-2 are simultaneously loaded by using PEG-PTMC polymer to prepare the NK cell synergistic stimulation polymeric micelle (PEG-PTMC-IL-2 / IL-15). The prepared NK cell synergistic stimulation polymeric micelle has high tumor inhibition rate, and is capable of effectively promoting apoptosis of tumor cells.
Owner:NORTHWESTERN POLYTECHNICAL UNIV
Preparation of dendrobium officinale polysaccharide lozenge and application of dendrobium officinale polysaccharide lozenge in immunopotentiation
PendingCN111557447ASignificant immune enhancement effectReasonable process designOrganic active ingredientsPharmaceutical non-active ingredientsWhite blood cellMagnesium stearate
The invention discloses preparation of a dendrobium officinale polysaccharide lozenge and an application of the dendrobium officinale polysaccharide lozenge in immunopotentiation. The total extractionprocess of the polysaccharide comprises the following steps: decocting and extracting dendrobium officinale coarse powder with 40 times of water for 2 hours, filtering, concentrating the filtrate to0.2 g of crude drug / ml, and precipitating with 5 times of ethanol by a water extraction and alcohol precipitation method to obtain the dendrobium officinale polysaccharide powder. The mannitol, aspartame, magnesium stearate, microcrystalline cellulose, menthol and povidone are added into the dendrobium polysaccharide powder to prepare lozenge. The lozenge can improve yin deficiency symptoms of yindeficiency model mice caused by thyroid hormone. Peripheral blood leukocyte WBC reduction of S180 tumor-bearing mice caused by 60Co radiotherapy is improved, and the number of bone marrow nucleated cells is increased. The effects of improving the activity of the body, resisting oxidative damage and enhancing immunity are shown. The dendrobium officinale polysaccharide lozenge prepared by the optimal dendrobium officinale polysaccharide extraction process screened by the invention has an obvious immunopotentiation effect, and can be used in the fields of immunopotentiation medicines, health-care products and foods.
Owner:上海市浦东新区浦南医院
Antitumor pharmaceutical composition and application thereof
PendingCN112263579AGood treatment effectHigh tumor inhibition rateOrganic active ingredientsPharmaceutical non-active ingredientsNeuroblastomaMuzolimine
The invention discloses an antitumor pharmaceutical composition and application thereof. The active ingredients of the antitumor pharmaceutical composition comprise polyethylene glycol modified camptothecin derivatives (especially polyethylene glycol modified irinotecan) and temozolomide. Animal experiments prove that the polyethylene glycol modified camptothecin derivatives (especially polyethylene glycol modified irinotecan) and temozolomide have an extremely strong treatment effect on tumors (such as neuroblastoma) by combined administration, and the tumor inhibition rate can reach 98% andis obviously superior to that of a single drug treatment group, so that the antitumor pharmaceutical composition provided by the invention has excellent application prospects in tumor treatment.
Owner:JENKEM TECH CO LTD TIANJIN
A probiotic fermented traditional Chinese medicine compound composition for treating liver cancer and its preparation and detection method
ActiveCN105749154BGreat tasteEnhance physical fitnessBacteriaComponent separationIrritationTherapeutic effect
Owner:SANZHU FUER PHARMA
Metal fullerol and its pharmaceutical use for inhibiting tumour growth
InactiveCN1935812BReduce dosageLow toxicityHydroxy compound active ingredientsGroup 3/13 element organic compoundsAbnormal tissue growthRare earth
The invention relates to metal fullerols and its application in preparing inhibition tumor medicine. Its general formula is M@C2m(OH)x, which M can be Gd, La, etc, m=41 or 30, x is not less than 10 and less than 50; it also can be M@C2mOxHy. Compared with clinic common using cyclophosphamide, cisplatin, paclitaxel etc, the metal fullerols M@C2m(OH)x or M@C2mOxHy has the advantages of little use level, low toxicity, high tumor inhibition ratio.
Owner:INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
Lenvatinib liposome, pharmaceutical composition thereof, preparation method thereof and prescription process optimization method
PendingCN112603890AGood biocompatibilityUniform and stable particle sizePharmaceutical non-active ingredientsAntineoplastic agentsSphingomyelinTumor site
The invention provides a lenvatinib (Len) liposome, a pharmaceutical composition thereof, a preparation method thereof and a prescription process optimization method. The liposome contains lenvatinib, phospholipid, an amphiphilic derivative, cholesterol and a gradient establishing substance, wherein the weight ratio of cholesterol to phospholipid is 1:2-1:10, the weight ratio of lenvatinib to phospholipid is 1:10-1:40, the weight ratio of the amphiphilic derivative to the phospholipid is 1:2-1:10, the phospholipid is glycerophospholipid or sphingomyelin, the gradient adopts a pH gradient method or an amine gradient method, and the concentration of the gradient establishing substance solution is 100-300mM. The Len liposome can actively target a tumor site through an SA-Siglec1 pathway, has the advantages of high encapsulation efficiency, high stability, high active targeting, high tumor inhibition rate and the like, and has good clinical application potential and product development value.
Owner:SHAOXING UNIVERSITY
Photo-thermal conversion nano composite material without toxic and side effects as well as preparation method and application thereof
PendingCN114831966AImprove adhesionGood biocompatibilityEnergy modified materialsElectro-spinningCancer cellSide effect
The invention discloses a photo-thermal conversion nano composite material without toxic and side effects as well as a preparation method and application thereof, and relates to the field of biological medicines. The photo-thermal conversion nano composite material comprises the following components: 3-13% (w / v) of polydopamine nano particles, 2-5% (w / w) of an anti-cancer drug, L-polylactic acid and polycaprolactone, the mass ratio of the poly-L-lactic acid to the polycaprolactone is (1: 3)-(4: 1). The preparation method comprises the following steps: mixing poly-L-lactic acid and polycaprolactone to prepare a degradable polymer colloid, embedding three-dimensional photo-thermal nanoparticles polydopamine and an anti-cancer drug into the degradable polymer colloid, preparing a nanofiber membrane by adopting a high-voltage electrostatic spinning method, and treating to remove a toxic organic solvent to obtain the photo-thermal conversion nano composite material. The photo-thermal conversion nano composite material is free of toxic and side effects, remarkable in photo-thermal curative effect, good in biocompatibility, uniform in nano particle distribution, good in toughness, capable of generating a remarkable heat effect on tumor tissues and capable of effectively killing cancer cells.
Owner:JINLIN MEDICAL COLLEGE
Composition containing nitrate, gastric floatation agent, preparation method and application
ActiveCN112516159BPromote absorptionEfficient use ofOrganic active ingredientsDigestive systemVitamin CSide effect
The invention provides a composition containing nitrate, a gastric flotation agent, a preparation method and application thereof, and belongs to the technical field of medicine; the composition includes the following raw materials: nitrate, vitamin C and vitamin B 2 . The composition of the invention can significantly increase the content of nitrate in the body, maintain blood drug concentration, produce radiation damage protection, and improve bioavailability. The composition of the present invention can be used to regulate cardiovascular function, improve and / or treat gastrointestinal stress injury, prevent liver degeneration and hepatic steatosis, or reduce damage caused by whole body radiation without any adverse side effects.
Owner:AIXI BEIJING INT CONSULTING CO LTD
A kind of injectable rare earth-DNA photothermal gel, its preparation method and application
ActiveCN111888324BReduce recurrenceReduce chance of diversionEnergy modified materialsAerosol deliveryTherapeutic effectBiocompatibility
The invention provides an injectable rare earth-DNA photothermal gel, comprising: negatively charged DNA molecules and positively charged rare earth-based nanomaterials; the positively charged rare earth-based nanomaterials are UCNP-Au . Under the action of physical entanglement, hydrogen bond and electrostatic force, DNA molecules and rare earth-based nanomaterials in the present invention form a hydrogel material with injectability, high-efficiency photothermal treatment effect and biocompatibility. Experimental results show that the photothermal efficiency of the injectable rare earth-DNA photothermal gel in the present invention can reach 42.67%. In addition, the tumor suppression rate is increased, thereby reducing the chance of tumor recurrence and metastasis. By means of paratumoral injection, the toxic and side effects of drugs on normal tissues during treatment can be reduced. Moreover, by adjusting the ratio of DNA molecules and rare earth-based nanomaterials, the degradation of photothermal gels in any time period can be realized. The operation of the invention is simple and fast, and the probability of tumor recurrence and metastasis is low.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
Lactobacillus kefiranofaciens, microbial inoculum and application of lactobacillus kefiranofaciens
ActiveCN114164148ARegulatory immunityPromote growthBacteriaDigestive systemBiotechnologyMicrobial agent
The invention provides lactobacillus kefiranofaciens, a microbial agent and application of the lactobacillus kefiranofaciens, and belongs to the technical field of microbial agents. The lactobacillus kefiranofaciens ZW18 disclosed by the invention can regulate tumor immunity, stimulate CD8 cell infiltration and promote expression of interleukin-12 (IL-12) and interferon gamma (IFN-gamma), so that tumor growth is slowed down. Secondly, the lactobacillus kefiranofaciens ZW18 can be used for optimizing the intestinal flora structure and improving the micro-ecological environment of the intestinal tract, and the abundance of beneficial bacteria such as PrevoteraceaeNK3B31group, Parabacteroides and the like in the intestinal tract can be improved; the beneficial bacteria can be metabolized to generate substances such as short-chain fatty acid, and organism immunity is regulated through blood, so that tumor growth is slowed down. In addition, the lactobacillus kefiranofaciens ZW18 can enhance the anti-tumor effect of the immune checkpoint therapy and overcome the anti-tumor drug resistance of the immune checkpoint therapy.
Owner:TIANJIN UNIV OF SCI & TECH
Preparation and purpose of MMP response type nanometer adriamycin-indocyanine green carrying hydrogel
InactiveCN110801517AReduce cardiotoxicityReduce skin phototoxicityOrganic active ingredientsPhotodynamic therapyChemo therapyBiology
The invention relates to MMP response type nanometer adriamycin-indocyanine green carrying hydrogel. A preparation method of the MMP response type nanometer adriamycin-indocyanine green carrying hydrogel comprises the following steps of: (1) preparing nanometer adriamycin granules and nanometer indocyanine green granules by an anti-solvent method, and performing freeze-drying and storage; and (2)accurately weighing a given amount of nanometer adriamycin freeze-dried powder and a given amount of nanometer indocyanine green freeze-dried powder, adding a TEA buffer solution, performing uniform mixing, accurately weighing a given quantity of acrylic ester-hyaluronic acid derivatives (HA-AC), adding the TEA buffer solution, performing uniform mixing, mixing two solutions in a certain proportion, adding an HS-MMP-SH cross-linking agent, performing placing in a thermotank of 37 DEG C, and performing cross-linking to obtain gel. According to the preparation method disclosed by the invention,MMP response type hydrogel is used as a carrier to wrap the nanometer adriamycin and nanometer indocyanine green, the MMP response type nanometer adriamycin-indocyanine green carrying hydrogel is injected into tumor positions in situ, and tumor cells can secrete a large amount of MMP, so that the hydrogel can be responded in the tumor position, degradation is accelerated, and controlled release and slow release of medicines can be realized; and besides, phototherapy and chemotherapy are united, so that the tumor restraining efficiency can be strengthened, and side effects of heart toxicity, skin phototoxicity and the like can be reduced.
Owner:温宁
A targeting material based on indole squaraine dye and its preparation method, fluorescent nanoparticles and its preparation method
ActiveCN109010826BReduce distractionsAmphipathicOrganic active ingredientsPowder deliveryTumor targetTumor targeting
The invention provides a targeting material based on indole squaraine dye, a preparation method thereof, fluorescent nanoparticles and a preparation method thereof. In the present invention, indole squaraine substituted with bromine, hydrogen or methyl is coupled with targeting polypeptide RGD molecule or with RGD molecule and anticancer drug camptothecin respectively to obtain amphiphilic diagnosis and treatment molecules. Such molecules can self-assemble in water to form stable nanoparticles with uniform size. The nanoparticles prepared by the present invention have near-infrared fluorescence emission, which can reduce the interference of background fluorescence and increase the signal penetration depth during the in vivo imaging process; the nanoparticles have tumor targeting properties, can be efficiently enriched in tumor tissue regions and realize precise in vivo Tumor fluorescence imaging; Nanoparticles have photodynamic properties, which can realize effective photodynamic therapy or combined photodynamic-chemotherapy for tumors. Therefore, the nanoparticles prepared by the present invention have good application prospects in the field of precise diagnosis and treatment of cancer.
Owner:BEIJING UNIV OF CHEM TECH
A pharmaceutical composition for treating tumors, its preparation method and application
ActiveCN106511414BHigh tumor inhibition rateGood antitumor activityAmphibian material medical ingredientsAntineoplastic agentsPharmaceutical drugOncology
The present invention provides a pharmaceutical composition for treating tumor and a preparation method thereof, wherein the pharmaceutical composition is prepared from Chinese Angelica and venenum bufonis. The pharmaceutical composition can significantly improve the tumor inhibition rate, and has significantly-improved antitumor activity compared with Antike capsule made from Chinese Angelica and Toad skin. The pharmaceutical composition is suitable for patients with advanced cancer, can be used as an antitumor adjuvant drug, can improve clinical symptoms and improves the quality of life.
Owner:长春雷允上药业有限公司
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