46results about How to "High tumor inhibition rate" patented technology

The invention discloses a preparation method and application of metal organic framework drug carrier system based on drug cytosine arabinoside micromolecule prodrug. The preparation method disclosed by the invention comprises the steps: choosing molecules which can generate coordination reaction with metal ions to be covalently combined with cytosine arabinoside to synthesize novel multifunctionalmicromolecule prodrug; carrying the prodrug on the metal organic framework through a simple environment-friendly one-step entrapment method to form medicine carrying nanoparticles; centrifuging, washing and drying to obtain a cytosine arabinoside micromolecule prodrug carrying MOF intravenous injection preparation. Taking synthesized Ara-IR820@ZIF-8 as an example, a mouse in-vivo antitumor pharmacological result shows that HA/Ara-IR820@ZIF-8 nano water solution has a good antitumor effect and lower system toxicity. The intravenous injection preparation has the advantages of high medicine carrying amount, simple and economic preparation process, batch production, small toxicity, good safety and wide application prospect in achieving high medicine carrying amount of the cytosine arabinosidein the metal organic framework and applying intravenous injection dosage to treat solid tumors.

The invention discloses an extraction method of a land slug and an anti-lung cancer application of the land slug. The extraction method comprises the following steps: (1) carrying out vacuum freeze-drying on the land slug, adding purified water and then carrying out water bath agitation, adding a high-concentration ethanol solution, evenly agitating until the ethanol concentration is 60-70%, standing and then carrying out solid-liquid separation; (2) clarifying and intercepting the liquid obtained in the step (1) by adopting an inorganic ceramic membrane system, so as to obtain total clear liquid of the land slug; (3) concentrating the total clear liquid of the land slug obtained in the step (2) by a reverse osmosis membrane; and (4) concentrating and drying ultra-filtrate obtained in the step (3), so as to obtain water-soluble land slug powder. The molecular weight of the land slug powder obtained by the method is concentrated between 20,000 and 30,000, and has a significant antitumor effect; the tumor control rate is higher than that of cinobufagin and close to that of cyclophosphamide. The water-soluble land slug powder disclosed by the invention is used for treating a lung cancer, and is efficient and low-toxicity.

The invention relates to metal fullerols and its application in preparing inhibition tumor medicine. Its general formula is M@C2m(OH)x, which M can be Gd, La, etc, m=41 or 30, x is not less than 10 and less than 50; it also can be M@C2mOxHy. Compared with clinic common using cyclophosphamide, cisplatin, paclitaxel etc, the metal fullerols M@C2m(OH)x or M@C2mOxHy has the advantages of little use level, low toxicity, high tumor inhibition ratio.

The invention develops a developed a thermosensitive injectable hydrogel based on HA and a copolymer of polyethylene oxide (PEO) and polypropylene oxide (PPO), which has a gel formation temperature from 30° C. to 37° C. The thermosensitive injectable hydrogel of the invention provides a potential drug delivery system that can increase therapeutic efficacy of the drug.

The invention belongs to the field of biotechnology and especially relates to a method for activation of a prodrug by tumor targeting bacteria and a use thereof. The method utilizes tumor targeting bacteria as natural prodrug activation tools; and the tumor targeting bacteria can realize constitutive expression of an endogenic prodrug activation enzyme gene thereby specifically activate a prodrug in tumor tissue and thus the activated prodrug can produce tumor-resistant effects. The method can be used for tumor treatment.

The invention belongs to the field of medicine preparations, which particularly relates to a long-circulation irinotecan lipidosome composition. The long-circulation irinotecan lipidosome composition is prepared from the following components in parts by weight: 1 part of irinotecan, 2 to 4 parts of hydrogenated soy phosphatidylcholine or distearoyl lecithin, 0.5 to 1.5 parts of cholesterol, 0.4 to 1.2 parts of phosphatidylethanolamine pegol and 0.0104 to 0.051 part of metal-chelator. The invention further discloses a preparation method of the long-circulation irinotecan lipidosome composition and an application of the long-circulation irinotecan lipidosome composition prepared into an irinotecan lipidosome composition injection. According to the irinotecan lipidosome composition and the preparation method thereof, the medicine loading ratio of the irinotecan is greatly improved and the encapsulation efficiency is greater than 99.5%, so that the toxic and side effect of the medicine which is not encapsulated can be obviously reduced; the content of relevant substances is lower than 0.5% and the limit of various toxic impurities is lower than 0.1%, so that the safety of the composition is obviously improved; and the composition is uniform in granularity distribution and good in stability.

The invention provides lactobacillus kefiranofaciens, a microbial agent and application of the lactobacillus kefiranofaciens, and belongs to the technical field of microbial agents. The lactobacillus kefiranofaciens ZW18 disclosed by the invention can regulate tumor immunity, stimulate CD8 cell infiltration and promote expression of interleukin-12 (IL-12) and interferon gamma (IFN-gamma), so that tumor growth is slowed down. Secondly, the lactobacillus kefiranofaciens ZW18 can be used for optimizing the intestinal flora structure and improving the micro-ecological environment of the intestinal tract, and the abundance of beneficial bacteria such as PrevoteraceaeNK3B31group, Parabacteroides and the like in the intestinal tract can be improved; the beneficial bacteria can be metabolized to generate substances such as short-chain fatty acid, and organism immunity is regulated through blood, so that tumor growth is slowed down. In addition, the lactobacillus kefiranofaciens ZW18 can enhance the anti-tumor effect of the immune checkpoint therapy and overcome the anti-tumor drug resistance of the immune checkpoint therapy.

The invention relates to MMP response type nanometer adriamycin-indocyanine green carrying hydrogel. A preparation method of the MMP response type nanometer adriamycin-indocyanine green carrying hydrogel comprises the following steps of: (1) preparing nanometer adriamycin granules and nanometer indocyanine green granules by an anti-solvent method, and performing freeze-drying and storage; and (2)accurately weighing a given amount of nanometer adriamycin freeze-dried powder and a given amount of nanometer indocyanine green freeze-dried powder, adding a TEA buffer solution, performing uniform mixing, accurately weighing a given quantity of acrylic ester-hyaluronic acid derivatives (HA-AC), adding the TEA buffer solution, performing uniform mixing, mixing two solutions in a certain proportion, adding an HS-MMP-SH cross-linking agent, performing placing in a thermotank of 37 DEG C, and performing cross-linking to obtain gel. According to the preparation method disclosed by the invention,MMP response type hydrogel is used as a carrier to wrap the nanometer adriamycin and nanometer indocyanine green, the MMP response type nanometer adriamycin-indocyanine green carrying hydrogel is injected into tumor positions in situ, and tumor cells can secrete a large amount of MMP, so that the hydrogel can be responded in the tumor position, degradation is accelerated, and controlled release and slow release of medicines can be realized; and besides, phototherapy and chemotherapy are united, so that the tumor restraining efficiency can be strengthened, and side effects of heart toxicity, skin phototoxicity and the like can be reduced.