Natural small molecule co-assembled nano-drug delivery system as well as preparation method and application thereof
A nano-drug and delivery system technology, applied in the field of nano-drug delivery system and its preparation, can solve the problems of limited natural small molecules, achieve good biocompatibility, slow systemic toxicity, and high tumor targeting effect
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Embodiment 1
[0056] This embodiment provides a natural small molecule co-assembled nanoparticle (NPs), the co-assembled nanoparticle is mainly prepared from Passepartout Acid (BTA) and paclitaxel (PTX). In this embodiment, the emulsified solvent volatilization method is used to prepare Passepartout acid-paclitaxel (BTA-PTX) nanoparticles, and the specific steps are as follows:
[0057] Dissolve 5 mg of Passepartout acid and 1.75 mg of paclitaxel in 1.0 mL of dichloromethane (if they cannot be completely dissolved, add a small amount of methanol as a co-solvent), and then add 3.0 mL of 2.5% polyvinyl alcohol (PVA ) aqueous solution (w / v), vortexed for 60 s, and immediately transferred the vortex liquid to a probe-type ultrasonic instrument to perform ultrasonic treatment on the mixture for 60 s. Then, the formed emulsion was added dropwise into 30 mL of 0.3% PVA aqueous solution (w / v) at a magnetic stirring speed of 400 rpm. The solution was stirred at room temperature for 6-8 hours to rem...
Embodiment 2
[0060] This example provides a natural small molecule co-assembled nanoparticle (NPs), which is mainly prepared from oleanolic acid (OA) and glycyrrhetinic acid (GA). In this embodiment, oleanolic acid-glycyrrhetinic acid (OA-GA) nanoparticles are prepared by emulsifying solvent evaporation method, and the specific steps are as follows:
[0061] Dissolve 2.5mg of oleanolic acid and 2.5mg of glycyrrhetinic acid in 1.0mL of dichloromethane (if they cannot be completely dissolved, add a small amount of methanol as a co-solvent), and then add them to 3.0mL of 2.5% polyethylene Alcohol (PVA) aqueous solution (w / v), vortexed for 60 s, and immediately transferred the vortex solution to a probe-type ultrasonic instrument for 60 s of ultrasonic treatment of the mixture. Then, the formed emulsion was added dropwise into 30 mL of 0.3% PVA aqueous solution (w / v) at a magnetic stirring speed of 400 rpm. The solution was stirred at room temperature for 6-8 hours to remove the organic solve...
Embodiment 3
[0064] This example provides a natural small molecule co-assembled nanoparticle (NPs), which is mainly prepared from betulin (Bet) and glycyrrhetinic acid (GA). In this embodiment, betulin-glycyrrhetinic acid (Bet-GA) nanoparticles are prepared by emulsifying solvent evaporation method, and the specific steps are as follows:
[0065] Dissolve 2.5 mg of betulin and 2.5 mg of glycyrrhetinic acid in 1.0 mL of dichloromethane (if they cannot be completely dissolved, a small amount of methanol can be added as a co-solvent), and then added to 3.0 mL of 2.5% polyvinyl alcohol ( PVA) aqueous solution (w / v), vortexed for 60 s, and immediately transferred the vortex liquid to a probe-type ultrasonic instrument to perform ultrasonic treatment on the mixture for 60 s. Then, the formed emulsion was added dropwise into 30 mL of 0.3% PVA aqueous solution (w / v) at a magnetic stirring speed of 400 rpm. The solution was stirred at room temperature for 6-8 hours to remove the organic solvent. ...
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