Antitumor pharmaceutical composition and application thereof

A composition and drug technology, applied in the field of medicine, can solve problems such as unsatisfactory effect

Pending Publication Date: 2021-01-26
JENKEM TECH CO LTD TIANJIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been reported that camptothecin derivatives are used in the treatment of neuroblastoma, especially relapsed and refractory neuroblastoma, but the effect is not ideal

Method used

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  • Antitumor pharmaceutical composition and application thereof
  • Antitumor pharmaceutical composition and application thereof
  • Antitumor pharmaceutical composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] 1. Experimental materials

[0110] 1.1 Experimental animals

[0111] Species: mouse

[0112] Strain: NOD / SCID

[0113] Age: 6-8 weeks

[0114] Gender: female

[0115] Quantity: 120 (100% extra animals)

[0116] Animal source: Shanghai Lingchang Experimental Animal Co., Ltd.

[0117] 1.2 Feeding conditions

[0118] The mice were kept in the CRO animal room designated by Jiankai.

[0119] Upon arrival of the animals, animal house staff transferred the animals from their shipping packages to their cages and inspected each animal. The scope of inspection includes appearance, limbs and cavities, etc., and whether there are any abnormalities when the animal is stationary or moving. The adaptation period is 7 days.

[0120] Environment: Mice will be housed in transparent resin plastic cages (300mm x 180mm x 120mm) in the animal room, with 5 mice per cage. Cage litter was autoclaved wood chips and corncob litter, which was changed twice a week. The room number in whi...

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Abstract

The invention discloses an antitumor pharmaceutical composition and application thereof. The active ingredients of the antitumor pharmaceutical composition comprise polyethylene glycol modified camptothecin derivatives (especially polyethylene glycol modified irinotecan) and temozolomide. Animal experiments prove that the polyethylene glycol modified camptothecin derivatives (especially polyethylene glycol modified irinotecan) and temozolomide have an extremely strong treatment effect on tumors (such as neuroblastoma) by combined administration, and the tumor inhibition rate can reach 98% andis obviously superior to that of a single drug treatment group, so that the antitumor pharmaceutical composition provided by the invention has excellent application prospects in tumor treatment.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to an antineoplastic pharmaceutical composition (the active ingredients of which include polyethylene glycol-modified camptothecin derivatives (especially polyethylene glycol-modified irinotecan) and temozolomide) and its application. Background technique [0002] Tumor is one of the common diseases that threaten human health, second only to cardiovascular disease. The research on tumor has made great progress, and a variety of radiotherapy, chemotherapy and other methods have been developed to treat tumors. However, various drugs and therapies There are limitations, it is difficult to achieve a radical effect, and prone to drug resistance and side effects. The mortality rate of cancer still ranks first in various diseases. Data show that in 2006, 3 million people died of cancer in my country, and the incidence of cancer is still on the rise, and there is a trend of young...

Claims

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Application Information

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IPC IPC(8): A61K31/4745A61K47/60A61P35/00A61K31/4188
CPCA61K31/4745A61K31/4188A61K47/60A61P35/00A61K2300/00A61K31/495
Inventor 王庆彬石娟胡静云赵宣
Owner JENKEM TECH CO LTD TIANJIN
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