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A probiotic fermented traditional Chinese medicine compound composition for treating liver cancer and its preparation and detection method

A technology for the treatment of liver cancer and detection method, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve problems such as intestinal flora imbalance, and achieve the effects of improving appetite, reducing irritation, and improving taste.

Active Publication Date: 2019-08-06
SANZHU FUER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chemotherapy drugs and radiation will kill probiotics and cause intestinal flora imbalance

Method used

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  • A probiotic fermented traditional Chinese medicine compound composition for treating liver cancer and its preparation and detection method
  • A probiotic fermented traditional Chinese medicine compound composition for treating liver cancer and its preparation and detection method
  • A probiotic fermented traditional Chinese medicine compound composition for treating liver cancer and its preparation and detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: Preparation of probiotic fermented traditional Chinese medicine compound composition A

[0038] Weigh each Chinese medicine ingredient according to the following weight: Bupleurum 20g, Scutellaria baicalensis 20g, red ginseng 8g, Tianjihuang 48g, weeping grass 48g, sunburned turtle shell 36g, salvia miltiorrhiza 36g, Prunella vulgaris 24g, raw oyster 40g, Corydalis 24g, sliced Turmeric 24g, Polyporus 24g, Zhilicorice 8g. Take the sun-burned turtle shell and crush it, pass through a 20-mesh sieve; add water to decoct twice with other twelve traditional Chinese medicines, add 12 times the amount of water for the first time and soak for 1.0 hour, decoct, keep boiling slightly for 1.0 hour after boiling, and add water for the second time Decoct with 10 times the amount of water, keep boiling slightly for 1.0 hour after boiling, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.01-1.05 (60°C) to obtain the Chinese medicine c...

Embodiment 2

[0039] Embodiment 2: the preparation of probiotic fermented traditional Chinese medicine compound composition B

[0040] Weigh each Chinese medicine ingredient according to the following weight: Bupleurum 20g, Scutellaria baicalensis 20g, red ginseng 8g, Tianjihuang 48g, weeping grass 48g, sunburned turtle shell 36g, salvia miltiorrhiza 36g, Prunella vulgaris 24g, raw oyster 40g, corydalis 24g, sliced Turmeric 24g, Polyporus 24g, Zhilicorice 8g. Take the sun-burned turtle and crush it, pass it through a 30-mesh sieve; add water to decoct twice with other twelve traditional Chinese medicines, add 12 times the amount of water for the first time, soak for 1.0 hour, decoct, keep boiling slightly for 1.0 hour after boiling, add water for the second time Decoct with 10 times the amount of water, keep boiling slightly for 1.0 hour after boiling, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.01-1.05 (60°C) to obtain a Chinese medicine compound...

Embodiment 3

[0041] Embodiment 3: Preparation of probiotic fermented traditional Chinese medicine compound composition C

[0042] Weigh each Chinese herbal ingredient according to the following weights: Bupleurum bupleuri 20g, Scutellaria baicalensis 20g, red ginseng 8g, Tianjihuang 48g, weeping grass 48g, sunburned turtle shell 36g, salvia miltiorrhiza 36g, Prunella vulgaris 24g, raw oyster 40g, Corydalis 24g, sliced Turmeric 24g, Polyporus 24g, Zhilicorice 8g. Take Sun-burned Turtle Shell and crush it, pass it through a 40-mesh sieve; add water to decoct twice with other twelve traditional Chinese medicines, add 12 times the amount of water for the first time, soak for 1.0 hour, decoct, keep boiling slightly for 1.0 hour after boiling, add water for the second time Decoct with 10 times the amount of water, keep at a slight boil for 1.0 hour after boiling, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.01-1.05 (60°C) to obtain a Chinese medicine com...

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Abstract

The invention discloses a probiotic fermented traditional Chinese medicine compound composition for treating liver cancer and preparation and detection methods thereof. The preparation method includes: performing water extraction on traditional Chinese medicine compound medicinal materials; adding nutrient and inorganic salt different in proportion; sterilizing at high temperature, and performing compound intestinal tract probiotic fermentation; stabilizing to obtain the probiotic fermented traditional Chinese medicine compound composition. The traditional Chinese medicine compound medicinal materials include Radix bupleuri, Radix scutellariae, Radix ginseng rubra, Herba hyperici japonici, string stonecrop herb, roasted turtle shell, root of red-rooted salvia, selfheal, raw oyster, Rhizoma corydalis, Radix curcuma piece, polyporus umbellatus and Radix Glycyrrhizae Preparata.The invention further discloses an identification method and a detection method of the probiotic fermented traditional Chinese medicine compound composition. Experiments show that treatment effect of traditional Chinese medicine extract can be improved remarkably, tumor inhibition rate can be increased, and the probiotic fermented traditional Chinese medicine compound composition has remarkable effect on inhibiting liver tumor growth. Taste of the traditional Chinese medicine compound extract can be improved remarkably, irritation of the traditional Chinese medicine extract to intestines and stomach can be reduced, and appetite and physique of patients can be improved.

Description

technical field [0001] The invention relates to a fermented composition obtained by fermenting traditional Chinese medicine extracts with intestinal probiotics, and the application of the fermented composition in the preparation of medicines for treating liver cancer, belonging to the technical field of biological fermentation. Background technique [0002] Hepatocellular carcinoma (HCC) is one of the common malignant tumors in my country. Its mortality rate ranks third among malignant tumors of the digestive system, second only to gastric cancer and esophageal cancer. Its incidence rate is on the rise, seriously endangering human health and survival. With the development of modern biomedical technology, clinical surgical technology, and minimally invasive treatment technology, the level of clinical diagnosis and treatment of liver cancer has shown steady and continuous improvement. In the past two decades, with the continuous development of medical physics, imaging, anesthe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K36/9066A61P35/00G01N30/90A61K35/586A61K35/618A61K35/745A61K35/747
CPCA61K35/586A61K35/618A61K35/745A61K35/747A61K36/07A61K36/185A61K36/233A61K36/258A61K36/41A61K36/484A61K36/536A61K36/537A61K36/539A61K36/66A61K36/9066A61K2236/19A61K2236/331A61K2236/39G01N30/90A61K2300/00
Inventor 吴炳新甄宗武褚新红牛纪江孙筱林
Owner SANZHU FUER PHARMA
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