The invention relates to the technical field of health foods, particularly to sesame oil capable of protecting blood vessels and activating appetite. The sesame oil is prepared by the following raw materials in weight parts: 1400 to 1500 parts of black sesame, 40 to 45 parts of perila seeds, 20 to 30 parts of almond, 25 to 30 parts of black fungus, 15 to 20 parts of garlic, 12 to 15 parts of cashew nut, 10 to 12 parts of tribulus terrestris, 15 to 20 parts of malt and 12 to 15 parts of chrysanthemum; in the sesame oil provided by the invention, various oil plants and Chinese herbal medicine components are contained, so that the health caring effect of the traditional sesame oil provided by the invention can be effectively promoted, and the obtained sesame oil is mellow in aromas, has transparent red and yellow color, and has health caring effects such as softening vessels, reducing blood fat, activating blood and reducing noise, appetizing and tonifying spleen, a relatively simple carbon dioxide subcritical extraction technology is adopted, the production process is environmentally friendly and efficient, and promotion and application values are achieved.