The invention discloses a sihuang anti-dysentery effervescent particle, belonging to the field of traditional Chinese pharmaceutics. The sihuang anti-dysentery effervescent particle comprises the following raw materials in parts by weight: 200 parts of coptis chinensis, 200 parts of phellodendron, 100 parts of rhubarb, 200 parts of scutellaria, 200 parts of isatis root and 100 parts of glycyrrhiza as well as adjuncts in parts by weight: 108-132 parts of sodium bicarbonate, 90-110 parts of fumaric acid, 549-671 parts of diluent and 18-22 parts of flavoring agent. The effervescent particle is prepared by adopting a method of granulation through acid and alkali separation. In the invention, for preparing the sihuang anti-dysentery effervescent particle, the sodium bicarbonate is used as an alkali agent, the fumaric acid is used as an acidizer, other adjuncts are also added, and the dosage of the adjuncts is reduced; in addition, the invention has the advantages of simple preparation technology, easy forming, difficult moisture absorption, rapid effervescence speed, good effervescence effect, good dissolubility, good physic liquor clarity without coke breezes and foreign matters and the like.