Preparation process of three-layer effervescent tablet comprising B vitamins

A technology of B vitamins and preparation process, which is applied in the field of preparation of three-layer effervescent tablets, can solve the problems of destroying the appearance of the tablet, affecting the disintegration of the tablet, and reducing the functional components, and achieves a smooth and bright surface with good stability , easy oral effect

Inactive Publication Date: 2013-05-08
DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the effervescent pairs are mixed with each other, this type of effervescent tablet is easy to react and release gas under high humidity conditions, which will not only damage the appearance of the tablet, affect the disintegration of the tablet, but also reduce the effective ingredients.

Method used

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  • Preparation process of three-layer effervescent tablet comprising B vitamins
  • Preparation process of three-layer effervescent tablet comprising B vitamins

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0010] Embodiment: the preparation of the three-layer effervescent tablet containing B vitamins

[0011] First Layer: Citric Acid 1050mg

[0012] Crospovidone 215mg

[0013] Vitamin B 1 2.4mg

[0014] Vitamin B 2 2.4mg

[0015] Vitamin B 6 2.4mg

[0016] Vitamin B 12 4.0μg

[0017] Macrogol 6000 90mg

[0018] Povidone K30 20mg

[0019] Appropriate amount of water

[0020] Second layer: Lactose 200mg

[0021] The third layer: sodium bicarbonate 750mg

[0022] Lactose 500mg

[0023] Crospovidone 100mg

[0024] Aspartame 20mg

[0025] Fragrance 10mg

[0026] Macrogol 6000 90mg

[0027] Povidone K30 35mg

[0028] Appropriate amount of water

[0029] Prepare as follows:

[0030] 1. Preparation of the granule part in the first layer: Povidone K30 is prepared into a binder solution with a concentration of 5-20% with an appr...

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PUM

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Abstract

The invention provides a preparation process of a three-layer effervescent tablet comprising B vitamins. The method comprises the steps that: (1) a slurry of an acid source and an internally added disintegrating agent prepared by using an adhesive is prepared into granules with a wet granulation method; the granules are uniformly mixed with B vitamins, a disintegrating agent, and a lubricant, such that a first layer is prepared; (2) a material used as a separation layer is adopted as a second layer; (3) a carbon dioxide source, lactose, and an internally added disintegrating agent are subjected to wet granulation; the obtained granules are uniformly mixed with a pigment, a sweetening agent, a disintegrating agent, and a lubricant, such that a third layer is obtained; and (4) the three-layer tablet is obtained by pressing the three layers. With the process provided by the invention, the prepared product has the advantages of smooth, bright, and clean surface, uniform surface color, good effervescent effect, good stability, low expansion under high humidity, convenient carrying, and easy oral administration.

Description

Technical field: [0001] The invention relates to the field of health food, in particular to a preparation process of a three-layer effervescent tablet containing B vitamins. Background technique: [0002] Effervescent tablets are a new dosage form made of effervescent materials as disintegrants. After being put into water, the acid source and carbon dioxide source in it react quickly to generate a large amount of carbon dioxide gas, which promotes the dissolution of the entire tablet in a short period of time. It has the characteristics of rapid onset of action, high bioavailability, and convenient carrying, and has the characteristics of both solid preparations and liquid preparations. [0003] B group vitamins include vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin, pantothenic acid, folic acid, etc. compound. These compounds are all present in natural food, and generally cannot be synthesized in the body or the amount of synthesis is small, which cannot meet the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/302A23L2/40A23P1/02A23L33/15
Inventor 张国栋华建君汪佳蕾朱炜边立峰
Owner DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) CO LTD
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