Process for preparing three-layer effervescent tablet containing vitamin C

A preparation process and vitamin technology, applied in the field of health food, can solve the problems of destroying the appearance of the tablet, affecting the disintegration of the tablet, reducing the functional components, etc., and achieving the effects of smooth and bright surface, good stability, and easy oral administration.

Inactive Publication Date: 2012-07-25
DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the effervescent pairs are mixed with each other, this type of effervescent tablet is easy to react and release gas under high humidity conditions, which will not only damage the appearance of the tablet, affect the disintegration of the tablet, but also reduce the effective ingredients.

Method used

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  • Process for preparing three-layer effervescent tablet containing vitamin C

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Embodiment

[0010] Example: Preparation of three-layer effervescent tablet containing vitamin C

[0011] First Layer: Citric Acid 1050mg

[0012] Crospovidone 215mg

[0013] Vitamin C 200mg

[0014] Macrogol 6000 90mg

[0015] Povidone K30 20mg

[0016] Appropriate amount of water

[0017] Second layer: Lactose 200mg

[0018] The third layer: sodium bicarbonate 750mg

[0019] Lactose 500mg

[0020] Crospovidone 100mg

[0021] Aspartame 20mg

[0022] Fragrance 10mg

[0023] Macrogol 6000 90mg

[0024] Povidone K30 35mg

[0025] Appropriate amount of water

[0026] Prepare as follows:

[0027] 1. Preparation of the granule part in the first layer: Prepare povidone K30 with an appropriate amount of water to form a binder solution with a concentration of 5-20%, stir and dissolve until the light yellow transparent solution.

[0028] 2. Crush the citric acid and pass through a 60-120 mesh sieve;

[0029] 3. Put citric acid and part of the cross-linked povidone into th...

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Abstract

The invention discloses a process for preparing a three-layer effervescent tablet containing vitamin C. The process comprises the steps of: (1) carrying out wet-process granulation on slurry prepared from an acid source and a bonding agent for an internally added disintegrating agent to prepare particles, and uniformly mixing the particles with the vitamin C, the disintegrating agent and a lubricating agent to serve as a first layer for later use; (2) taking materials used as a middle isolation layer as a second layer for later use; (3) carrying out wet-process granulation on a carbon dioxide source, lactose and the internally added disintegrating agent to prepare particles, and uniformly mixing the particles with pigment, a sweetener, the disintegrating agent and the lubricating agent to serve as a third layer; and (4) pressing together to obtain a three-layer tablet. A product prepared according to the invention has the advantages of smooth and bright surface, uniform glossiness, good effervescent effect, favorable stability, smaller expansion under a high humidity state, convenience in carrying, and simpleness for oral administration.

Description

Technical field: [0001] The invention relates to the field of health food, in particular to a preparation process of a vitamin C-containing three-layer effervescent tablet. Background technique; [0002] Effervescent tablets are a new dosage form made of effervescent materials as disintegrants. After being put into water, the acid source and carbon dioxide source in it react quickly to generate a large amount of carbon dioxide gas, which promotes the dissolution of the entire tablet in a short period of time. It has the characteristics of rapid onset of action, high bioavailability, and convenient carrying, and has the characteristics of both solid preparations and liquid preparations. [0003] Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin and one of the nutrients necessary to maintain normal health of the human body. When it is deficient, it will cause scurvy. Due to the lack of gulonolactone oxidase necessary for conversion into vitamin C, the huma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/29A23L33/00
Inventor 张国栋刘锋张勇丁亚芳史解矛
Owner DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) CO LTD
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