Preparation technology for three-layer effervescent tablet containing glucosamine
A preparation process and glucose technology, applied in the field of preparation of three-layer effervescent tablets, can solve the problems of affecting tablet disintegration, destroying the appearance of tablets, reducing functional components, etc., achieving smooth and bright surface, easy oral administration, effervescence good effect
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[0010] Example: Preparation of three-layer effervescent tablet containing glucosamine
[0011] First Layer: Citric Acid 1050mg
[0012] Crospovidone 215mg
[0013] Glucosamine 250mg
[0014] Macrogol 6000 90mg
[0015] Povidone K30 20mg
[0016] Appropriate amount of water
[0017] Second layer: Lactose 200mg
[0018] The third layer: sodium bicarbonate 750mg
[0019] Lactose 500mg
[0020] Crospovidone 100mg
[0021] Aspartame 20mg
[0022] Fragrance 10mg
[0023] Macrogol 6000 90mg
[0024] Povidone K30 35mg
[0025] Appropriate amount of water
[0026] Prepare as follows:
[0027] 1. Preparation of the granule part in the first layer: Prepare povidone K30 with an appropriate amount of water to form a binder solution with a concentration of 5-20%, stir and dissolve until the light yellow transparent solution;
[0028] 2. Crush the citric acid and pass through a 60-120 mesh sieve;
[0029] 3. Put citric acid and part of cross-linked povidone into th...
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