Preparation technology for three-layer effervescent tablet containing glucosamine

A preparation process and glucose technology, applied in the field of preparation of three-layer effervescent tablets, can solve the problems of affecting tablet disintegration, destroying the appearance of tablets, reducing functional components, etc., achieving smooth and bright surface, easy oral administration, effervescence good effect

Inactive Publication Date: 2012-07-18
DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the effervescent pairs are mixed with each other, this type of effervescent tablet is easy to react and release gas under high humidity conditions, which will not only damage the appearance of the tablet, affect the disintegration of the tablet, but also reduce the effective ingredients.

Method used

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  • Preparation technology for three-layer effervescent tablet containing glucosamine

Examples

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Effect test

Embodiment

[0010] Example: Preparation of three-layer effervescent tablet containing glucosamine

[0011] First Layer: Citric Acid 1050mg

[0012] Crospovidone 215mg

[0013] Glucosamine 250mg

[0014] Macrogol 6000 90mg

[0015] Povidone K30 20mg

[0016] Appropriate amount of water

[0017] Second layer: Lactose 200mg

[0018] The third layer: sodium bicarbonate 750mg

[0019] Lactose 500mg

[0020] Crospovidone 100mg

[0021] Aspartame 20mg

[0022] Fragrance 10mg

[0023] Macrogol 6000 90mg

[0024] Povidone K30 35mg

[0025] Appropriate amount of water

[0026] Prepare as follows:

[0027] 1. Preparation of the granule part in the first layer: Prepare povidone K30 with an appropriate amount of water to form a binder solution with a concentration of 5-20%, stir and dissolve until the light yellow transparent solution;

[0028] 2. Crush the citric acid and pass through a 60-120 mesh sieve;

[0029] 3. Put citric acid and part of cross-linked povidone into th...

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Abstract

The invention relates to a preparation technology for a three-layer effervescent tablet containing glucosamine. The preparation technology comprises the following steps of: 1) evenly mixing granules made of source acid, internally added disintegrating agent and slurry prepared by using adhesive through a wet process granulation method with glucosamine, disintegrating agent and lubricating agent, and using the mixture as a first layer for future use; 2) using materials which are used as an isolating layer as a second layer for future use; 3) evenly mixing granules made of source carbon dioxide, lactose, internally added disintegrating agent through the wet process granulation method with pigment, sweetener, disintegrating agent and lubricating agent, and using the mixture as a third layer; and 4) pressing the raw materials into three-layer tablets. The three-layer effervescent tablet produced by adopting the preparation technology has the advantages that the surface is smooth and bright, the color is even, the effervescent effect is good, the stability is good, the expansion in a high-humidity state is smaller and the tablet is convenient to carry and easy to orally taken.

Description

Technical field: [0001] The invention relates to the field of health food, in particular to a preparation process of a three-layer effervescent tablet containing glucosamine. Background technique: [0002] Effervescent tablets are a new dosage form made of effervescent materials as disintegrants. After being put into water, the acid source and carbon dioxide source in it react quickly to generate a large amount of carbon dioxide gas, which promotes the dissolution of the entire tablet in a short period of time. It has the characteristics of rapid onset of action, high bioavailability, and convenient carrying, and has the characteristics of both solid preparations and liquid preparations. [0003] Glucosamine, which has important physiological functions for the human body, participates in liver and kidney detoxification, plays an anti-inflammatory and liver-protecting role, has a good effect on the treatment of rheumatoid arthritis and gastric ulcer, and is the main raw mate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/09A23P1/02
Inventor 张国栋张兴张涛陈银富毛剑平
Owner DSM JIANGSHAN PHARMACEUTICAL (JIANGSU) CO LTD
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