Effervescence tablet of Chinese magnoliavine fruit and its preparation process

A technology of Schisandra chinensis and effervescent tablets, applied in the field of traditional Chinese medicine effervescent tablets, can solve the problems of unsatisfactory solution stability, inaccurate patient dosage, large packaging volume, etc., achieve uniform appearance and various components, and is beneficial to Environmental protection and strong controllability

Inactive Publication Date: 2009-03-11
SHANGHAI HUATUO MEDICAL SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Syrup is an oral liquid preparation, the packaging volume is large, it is inconvenient to carry, and the bottom of the syrup is prone to precipitation, which leads to inaccurate dosage of patients, which affects the efficacy of the drug, and the stability of the solution is not ideal
Especially syrups contain high concentration of sucrose, which is not good for some people who need to limit sugar intake

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of embodiment 1 schisandra extract powder

[0035]Weigh 500 grams of schisandra coarse powder. Use 500ml of 30% (V / V) ethanol as a solvent, soak for 72 hours, slowly percolate until the filtrate is 1000ml, filter with qualitative filter paper, concentrate under reduced pressure to a specific gravity of 1.15 (60°C), after determination, concentrate The solid content of the liquid is 34.6% (weight ratio), thus the solid content is 141g, add 42.3g maltodextrin, stir evenly, adopt TWG-120 type spray dryer (Shandong Tianli Drying Equipment Factory) to carry out spray drying , Control inlet temperature 130 ℃, outlet temperature 85 ℃, get 185g spray dry powder, after measuring, its water content is 1.95%.

Embodiment 2

[0036] The preparation of embodiment 2 alkali agent

[0037] When using this effervescent tablet, the human body takes in the same amount (mole) of potassium and sodium, and anhydrous potassium carbonate and sodium bicarbonate are pre-mixed as the alkali agent in the effervescent agent. The molecular weight of potassium carbonate is 138.2, 2 valences, the molecular weight of sodium bicarbonate is 84, 1 valence, and the anhydrous potassium carbonate and sodium bicarbonate are mixed by weighing anhydrous potassium carbonate and sodium bicarbonate in a weight ratio of 1:1.2 to be a mixed alkali, and the potassium-sodium molar ratio contained in it is 1 : 1. When malic acid (molecular weight 134.1, divalent) is used as the acid agent in the effervescent agent, the equivalent mass ratio of acid to base is 0.876:1, that is, 0.876 parts of malic acid and 1 part of the above mixed base just completely react. If tartaric acid (molecular weight 150.09, divalent) is used as the acid age...

Embodiment 3-4

[0038] Examples 3-4 are preparation examples of effervescent tablets. In the preparation examples, the extract powder prepared in Example 1 is used as the extract powder of Schisandra chinensis. The raw materials of other components are commercially available pharmaceutical grade or food grade commodities. The mixed alkali is the alkali agent prepared in Example 2. The mixing operation in the effervescent tablet preparation process was carried out in the HD-50 three-dimensional mixer (Changzhou Jiafa Drying Equipment Factory), and the mixing speed was 12 revolutions per minute; Dry granulation was carried out with a French granulator; a die with a diameter of 1.0 cm was used for tablet compression, and a TDK tablet press machine produced by Shanghai Far East Medical Machinery Factory was used for tablet compression molding. The operations of mixing, granulating and tabletting are all carried out under the ambient conditions of 25°C and 40% relative humidity.

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PUM

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Abstract

The invention relates to an effervescent tablet of Chinese magnoliavine fruit and its preparation process, which comprises (by weight ratio) schisandra fruit extract powder 15-50%, effervescent agent 40-75%, lubricant 1-15%, flavoring agent 1-10%. The preparing process comprises making schisandra fruit extract powder through spray-drying, then preparing granule through dry method palletizing.

Description

technical field [0001] The invention relates to a traditional Chinese medicine effervescent tablet, in particular to an effervescent tablet containing the traditional Chinese medicine Schisandra chinensis. [0002] The invention also relates to a preparation method of the effervescent tablet. Background technique [0003] Schisandra chinensis is the dry mature fruit of Schisandra chinensis (Turcz.) Baill. The fruits are picked when they are ripe in autumn, dried in the sun or steamed, and the stems and impurities are removed. They are rich in volatile oils, organic acids, lignans and other beneficial ingredients. Fructus Schisandra has the effects of nourishing qi and tonifying kidney, calming and calming the nerves, and is used for diseases such as neurasthenia, dizziness, and insomnia. At present, Schisandra Syrup is mainly on the market. The syrup is an oral liquid preparation, the packaging volume is large, it is inconvenient to carry, and the bottom of the syrup is p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K36/79A61P25/20
Inventor 潘俊芳曾佳烽方通赵雪斌单圆圆郑洁
Owner SHANGHAI HUATUO MEDICAL SCI CO LTD
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