A kind of effervescent tablet of traditional Chinese medicine

An effervescent tablet, traditional Chinese medicine technology, applied in the directions of drug delivery, pharmaceutical formulations, plant raw materials, etc., can solve problems such as sticking and punching, achieve good taste, relax the requirements of environmental temperature and humidity, and solve the effect of sticking and punching

Active Publication Date: 2017-12-01
BY HEALTH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The formula of the effervescent tablet of traditional Chinese medicine solves the problem of stickiness and astringency in the effervescent tablet of the raw material of traditional Chinese medicine, and relaxes the requirements for environmental temperature and humidity during production. , good effervescent effect, etc.

Method used

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  • A kind of effervescent tablet of traditional Chinese medicine
  • A kind of effervescent tablet of traditional Chinese medicine
  • A kind of effervescent tablet of traditional Chinese medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] The screening of embodiment 1 Chinese medicine effervescent tablet lubricant

[0063] The formula of traditional Chinese medicine effervescent tablet is as shown in table 1.

[0064] The formula of table 1 Chinese medicine effervescent tablet

[0065]

[0066] The raw and auxiliary materials of the above formulations 1 to 4 were subjected to a tablet compression test: the tablet was continuously compressed for 30 minutes at a temperature of 25°C and a humidity of 25% RH to observe and compare the sticking and astringent effects of different lubricants under the same conditions. Carry out effervescent effect test after tablet compression finishes, and test result is as shown in the following table:

[0067] The effect test of formula 1~prescription 4 of table 2

[0068]

[0069]

[0070] From the test results in Table 2, it can be seen that among the lubricants commonly used in the above four tablets, fumaric acid can achieve the same lubricating effect as mag...

Embodiment 2

[0071] The preparation of embodiment 2 Chinese medicine effervescent tablets

[0072] The formula of traditional Chinese medicine effervescent tablet is as shown in table 3.

[0073] The formula of table 3 traditional Chinese medicine effervescent tablet

[0074]

[0075] The preparation method is as follows: crush anhydrous sodium carbonate, granulate with other raw and auxiliary materials through absolute ethanol, dry, arrange, mix and compress into tablets to obtain effervescent tablets of traditional Chinese medicine.

Embodiment 3

[0076] The preparation of embodiment 3 Chinese medicine effervescent tablets

[0077] The formula of traditional Chinese medicine effervescent tablet is as shown in table 4.

[0078] The formula of table 4 Chinese medicine effervescent tablet

[0079]

[0080] The preparation method is as follows: crush anhydrous sodium carbonate, granulate with other raw and auxiliary materials through absolute ethanol, dry, arrange, mix and compress into tablets to obtain effervescent tablets of traditional Chinese medicine.

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PUM

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Abstract

The invention relates to the technical field of preparations, in particular to a traditional Chinese medicine effervescent tablet. The traditional Chinese medicine effervescent tablet comprises an active ingredient, an acid source, an alkali source, a lubricant and a surfactant; the lubricant is fumaric acid; and the acid source is a mixture of citric acid and tartaric acid. The Chinese medicine effervescent tablet formula provided by the present invention solves the ubiquitous problems of stickiness and astringency in Chinese medicine effervescent tablets, and relaxes the requirements for environmental temperature and humidity during production. The hardness and friability meet the tablet requirements, and at the same time It has the advantages of rapid disintegration, no effect on the clarity of the solution, and good effervescent effect.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a traditional Chinese medicine effervescent tablet. Background technique [0002] An effervescent tablet is a tablet that contains an effervescent disintegrant. The effervescent disintegrating agent is usually a mixture of organic acid, sodium carbonate, and sodium bicarbonate (baking soda); the effervescent tablet itself is dry and does not contain moisture, and the two substances in the effervescent disintegrating agent are not ionized and cannot react; but when After the effervescent tablet is placed in water, the two substances undergo an acid-base reaction, producing a large amount of carbon dioxide, which causes the tablet to disintegrate and melt rapidly. Sometimes the bubbles generated by the disintegration will cause the tablet to roll up and down in the water, accelerating its disintegration and melting . The carbon dioxide produced when the tablet...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K47/12A61K36/258A61K35/36
Inventor 彭辉蒋丽殷光玲黄远英张铭辉李伟佳张保献张卫华吴涛
Owner BY HEALTH CO LTD
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