Sihuang Zhili effervescent granule and preparation method thereof

A technology for effervescent granules and anti-diarrhea, which is applied to pharmaceutical formulas, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. Slow disintegration time, easy to generate gas and other problems, to achieve the effect of good clarity, fast effervescence and good effervescence effect

Active Publication Date: 2011-12-14
HENAN HUITONG TIANXIA BIO ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the large proportion of medicinal extracts in Chinese medicine effervescent granules, it is difficult to select the type and proportion of medicinal extracts and pharmaceutical excipients. Most of the existing Chinese medicine effervescent granules have slow disintegration time, poor stability, and poor taste Common issues such as sexual difference
At the same time, due to the acid-base reaction of the disintegrant itself and the influence of environmental moisture during the storage process, the effervescent granules are prone to produce gas, which makes the prepared product appear swollen bags, gas and other adverse conditions.

Method used

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  • Sihuang Zhili effervescent granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] 1. Sihuang Zhili Effervescent Granules are prepared according to the following raw materials and auxiliary materials in the weight ratio:

[0053] Raw materials: Coptis 200g, Phellodendron 200g, Rhubarb 100g, Scutellaria baicalensis 200g, Radix Radix 200g, Licorice 100g;

[0054] Excipients: 120g sodium bicarbonate, 100g fumaric acid, diluent: 560g glucose, 50g dextrin, flavoring agent: 20g stevia.

[0055] 2. The preparation method of Sihuang Zhili Effervescent Granules:

[0056] (1) Weigh the prescription amount of Coptis chinensis, Phellodendron cortex, rhubarb, scutellaria baicalensis, Radix Radix, and licorice, soak in water with 8 times the weight of the medicinal materials for 4 hours, heat and decoct, the first time for 2 hours, and the second time add the dregs of the medicine to 8 times the weight of the medicinal materials decoct in water for 1 hour, combine the decoction, filter, combine the filtrate, let it stand, take the supernatant and concentrate it un...

Embodiment 2

[0061] 1. Sihuang Zhili Effervescent Granules are prepared according to the following raw materials and auxiliary materials in the weight ratio:

[0062] Raw materials: Coptis 200g, Phellodendron 200g, Rhubarb 100g, Scutellaria baicalensis 200g, Radix Radix 200g, Licorice 100g;

[0063] Excipients: 108g sodium bicarbonate, 90g fumaric acid, diluent: 600g glucose, flavoring agent: 20g vanillin.

[0064] 2. Preparation method of Sihuang Zhili Effervescent Granules: Repeat the preparation method of Example 1 to obtain Sihuang Zhili Effervescent Granules of the present invention.

Embodiment 3

[0066] 1. Sihuang Zhili Effervescent Granules are prepared according to the following raw materials and auxiliary materials in the weight ratio:

[0067] Raw materials: Coptis 200g, Phellodendron 200g, Rhubarb 100g, Scutellaria baicalensis 200g, Radix Radix 200g, Licorice 100g;

[0068] Excipients: 116g sodium bicarbonate, 95g fumaric acid, diluent: 300g glucose, 200g lactose, 49g mannitol, flavoring agent: 10g sodium saccharin, 9g glycyrrhizin.

[0069] 2. Preparation method of Sihuang Zhili Effervescent Granules: Repeat the preparation method of Example 1 to obtain Sihuang Zhili Effervescent Granules of the present invention.

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Abstract

The invention discloses a sihuang anti-dysentery effervescent particle, belonging to the field of traditional Chinese pharmaceutics. The sihuang anti-dysentery effervescent particle comprises the following raw materials in parts by weight: 200 parts of coptis chinensis, 200 parts of phellodendron, 100 parts of rhubarb, 200 parts of scutellaria, 200 parts of isatis root and 100 parts of glycyrrhiza as well as adjuncts in parts by weight: 108-132 parts of sodium bicarbonate, 90-110 parts of fumaric acid, 549-671 parts of diluent and 18-22 parts of flavoring agent. The effervescent particle is prepared by adopting a method of granulation through acid and alkali separation. In the invention, for preparing the sihuang anti-dysentery effervescent particle, the sodium bicarbonate is used as an alkali agent, the fumaric acid is used as an acidizer, other adjuncts are also added, and the dosage of the adjuncts is reduced; in addition, the invention has the advantages of simple preparation technology, easy forming, difficult moisture absorption, rapid effervescence speed, good effervescence effect, good dissolubility, good physic liquor clarity without coke breezes and foreign matters and the like.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a Sihuang Zhili effervescent granule and a preparation method thereof. Background technique [0002] Sihuang Zhili Granules are granules made of Coptis chinensis, Cortex Phellodendron, Rhubarb, Scutellaria, Banlangen, and Licorice, which are extracted and processed into Sihuang Zhili Extract, and then mixed with sucrose and dextrin in a certain proportion. The efficacy of fire and dysentery is mainly used clinically for the treatment of damp-heat diarrhea and chicken colibacillosis, such as damp-heat diarrhea, pullorum, yellow diarrhea caused by E. White dysentery, watery diarrhea, etc.; diarrhea caused by Escherichia coli and Salmonella, yellow and white diarrhea, infectious gastroenteritis, epidemic diarrhea, rotavirus diarrhea and other viral diseases caused by severe jet-like watery diarrhea, etc. Because of its exact curative effect and good ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61K9/16A61K47/12A61K47/02A61P31/04A61P1/12
CPCY02A50/30
Inventor 张要齐李怀生孙雪峰朱静静
Owner HENAN HUITONG TIANXIA BIO ENG
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