Preparation method of effervescent tablet

A technology of effervescent tablets and citric acid, applied in the field of effervescent tablets, can solve the problems of bulging bags, easy moisture absorption, cracks, etc., and achieve the effects of long shelf life, one-sided gloss, and fast effervescent speed.

Inactive Publication Date: 2018-12-11
江苏汉典生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of effervescent tablets usually adopts the water granulation process. The biggest disadvantage of the effervescent tablets produced by this method is that it is easy to absorb moisture or deliquesce, resulting in splits and bag swelling.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1, a kind of preparation method of effervescent tablet, comprises the following steps:

[0023] (1) Material preparation: under the condition that the workshop temperature is 18-25°C and the humidity is lower than 40% relative humidity, weigh the required amount of citric acid, pigment and sucralose sweetener, pulverize and pass through an 80-mesh sieve;

[0024] (2) Mixing: the pulverized citric acid, pigment and sucralose are mixed by step-by-step amplification. The stirring speed is 24 rev / min, and the mixing time is 5min;

[0025] (3) Granulation: Spray 70-90% ethanol solution while stirring the mixture until it reaches the bonding state of "holding into agglomerates, loosening and loosening", and use a granulator to process the mixed materials. Granules, and pass through a 12-mesh sieve;

[0026] (4) Drying: Spread the prepared granules on the baking tray, control the thickness of each tray at 1.5-2cm, bake at 48°C for 90 minutes, then turn the materials in the b...

Embodiment 2

[0032] 1, a kind of preparation method of effervescent tablet, comprises the following steps:

[0033] (1) Material preparation: under the condition that the workshop temperature is 18-25°C and the humidity is lower than 40% relative humidity, weigh the required amount of citric acid, pigment and sucralose sweetener, pulverize and pass through an 80-mesh sieve;

[0034] (2) Mixing: the pulverized citric acid, pigment and sucralose are mixed by step-by-step amplification. The stirring speed is 24 rev / min, and the mixing time is 5min;

[0035] (3) Granulation: Spray 70% 90% ethanol solution while stirring the mixture until it reaches the bonding state of "holding into agglomerates, loosening and loosening", and use a granulator to process the mixed materials. Granules, and pass through a 12-mesh sieve;

[0036] (4) Drying: Spread the prepared granules on the baking tray, control the thickness of each tray at 1.5-2cm, bake at 50°C for 80 minutes, then turn the materials in the ...

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PUM

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Abstract

The invention belongs to the technical field of effervescent tablets, and particularly relates to a preparation method of an effervescent tablet, wherein the preparation method comprises material preparing, material mixing, granulating, drying, pelletizing, uniform mixing, tabletting, and other steps. According to the present invention, the effervescent tablet prepared through the method has advantages of rapid disintegration, good stability, long storage period, relatively simple process and controllable quality.

Description

technical field [0001] The invention belongs to the technical field of effervescent tablets, and in particular relates to a preparation method of effervescent tablets. Background technique [0002] Effervescent tablet is a new type of tablet. Compared with traditional dosage forms, it has the advantages of convenient taking and carrying, rapid dissolution and absorption, quick onset of action, high bioavailability, and unique color and fragrance. Effervescent tablets are especially suitable for children and the elderly, who have difficulty swallowing ordinary tablets and are prone to lack of such vitamins; at the same time, vitamin effervescent tablets are also suitable for white-collar workers with fast-paced lives. The preparation of effervescent tablets usually adopts the water granulation process. The biggest disadvantage of the effervescent tablets produced by this method is that they are easy to absorb moisture or deliquesce, resulting in splits and bag swelling. Con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L2/40
CPCA23L2/40A23L19/01A23L33/10A23P10/28
Inventor 丁向东杜建忠严梦娟
Owner 江苏汉典生物科技股份有限公司
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