Acetaminophen effervescent tablets and preparation method thereof

A technology for acetaminophen and effervescent tablets, which is applied in pharmaceutical formulations, pill delivery, and inorganic non-active ingredients. It can solve problems such as poor effervescent effect and large amount of alkali source used, so as to promote dissolution and reduce toxic and side effects , enhance the effect of bioavailability

Inactive Publication Date: 2018-06-19
重庆希尔安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide a kind of acetaminophen effervescent tablet, which can solve the technical problem of using only a single alkali source in the effervescent tablet in the prior art, resulting in a large amount of alkali source used and poor effervescent effect

Method used

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  • Acetaminophen effervescent tablets and preparation method thereof
  • Acetaminophen effervescent tablets and preparation method thereof
  • Acetaminophen effervescent tablets and preparation method thereof

Examples

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preparation example Construction

[0022] The embodiment of the present invention also provides a kind of preparation method of acetaminophen effervescent tablet, is the following steps:

[0023] S1, pretreatment;

[0024] Preparation of compound disintegrant: mix carboxymethyl starch sodium and carboxymethyl cellulose sodium in proportion.

[0025] Sodium bicarbonate, bisglycinate sodium carbonate, anhydrous sodium carbonate, acetaminophen, aspartame, compound disintegrant, (internal addition) (internal addition is the granulation process) were passed through 100-150 mesh respectively Sieve, fumaric acid, compound disintegrant (external addition) (external addition is the process of total mixing) pass through 60-80 mesh sieve respectively.

[0026] Preparation of composite adhesive: an aqueous solution prepared by dissolving erythritol and sodium saccharin in water. The erythritol and sodium saccharin are dissolved so that the two have bonding properties, and then various materials can be bonded to obtain pa...

Embodiment 1

[0043] The present embodiment provides a kind of acetaminophen effervescent tablet (80,000 pieces), and it is made by multiple raw materials, and multiple raw materials are 5Kg paracetamol, 12.5Kg compound alkali source, 7Kg fumaric acid, 0.96Kg composite binder, 2.1Kg modifier and 0.13Kg composite disintegrant. Among them, 12.5Kg composite alkali source is 7Kg sodium bicarbonate, 5Kg sodium bisglycinate sodium carbonate and 0.5Kg sodium carbonate; 0.96Kg composite binder is 0.48Kg erythritol and 0.48Kg sodium saccharin; 2.1Kg modifier is 0.1 Kg lemon essence and 2Kg aspartame; 0.13Kg compound disintegrant is 0.1Kg carboxymethyl starch sodium and 0.03Kg carboxymethyl cellulose sodium.

[0044] The present embodiment provides a kind of preparation method of paracetamol effervescent tablet, comprises the following steps:

[0045] S1, pretreatment;

[0046] Preparation of compound disintegrant: mix carboxymethyl starch sodium and carboxymethyl cellulose sodium in proportion.

...

Embodiment 2

[0064] This embodiment provides an acetaminophen effervescent tablet, the composition of which is the same as that of the acetaminophen effervescent tablet provided in Example 1, the difference is that the usage amount of each raw material changes. Specifically, the various raw and auxiliary materials are 10Kg paracetamol, 20Kg compound alkali source, 15Kg fumaric acid, 1.5Kg compound binder, 3.25Kg modifier and 0.24Kg compound disintegrant. Among them, the 20Kg composite alkali source is 12Kg bicarbonate, 7Kg bisglycinate sodium carbonate and 1Kg sodium carbonate; the 1.5Kg composite binder is 0.75Kg erythritol and 0.75Kg sodium saccharin. The 0.24Kg compound disintegrant is 0.2Kg sodium carboxymethyl starch and 0.04Kg carboxymethylcellulose sodium; the 3.25Kg modifier is 0.25Kg strawberry essence and 3Kg steviol glycoside.

[0065] This example provides a method for preparing acetaminophen effervescent tablets, the composition of which is the same as that of the method for p...

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Abstract

The invention relates to the pharmaceutical field, in particular to acetaminophen effervescent tablets and a preparation method thereof. The acetaminophen effervescent tablets are mainly prepared fromvarious raw and auxiliary materials. The various raw and auxiliary materials comprise 5 to 10 parts of acetaminophen, 12.5 to 20 parts of a compound alkali source, 7 to 15 parts of an acid source, 0.96 to 1.5 parts of a compound adhesive, 2.1 to 3.25 parts of a modifier and 0.13 to 0.24 parts of a compound disintegrating agent. The acetaminophen effervescent tablets can solve the technical problems of a large use amount of an alkali source due to application of a single alkali source and a poor effervescent effect caused by long-term storage of existing effervescent tablets in the prior art.Meanwhile, the acetaminophen effervescent tablets taste good; the drug application compliance is improved; the stability is high; furthermore, the acetaminophen effervescent tablets are low in toxic and side effect, so that products are high in safety.

Description

technical field [0001] The invention relates to the field of pharmacy, in particular to a paracetamol effervescent tablet and a preparation method thereof. Background technique [0002] Acetaminophen effervescent tablets are antipyretic and analgesic over-the-counter drugs, used for fever caused by the common cold or influenza, and also used to relieve mild to moderate pain such as headache, joint pain, migraine, toothache, muscle pain, neuralgia, dysmenorrhea. Effervescent tablets generally use acid-base neutralization to generate carbon dioxide to accelerate the disintegration of the tablet and increase the rate of drug dissolution. For example, the patent application number CN201210245315.3 uses only sodium bicarbonate as an alkali source, and the disintegration speed of the obtained effervescent granules is relatively poor. For example, the application number is CN200910228467.0, and an alkali source is also used , and the addition of a large amount of alkali source. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/02A61K31/167A61P29/00
CPCA61K9/0007A61K9/2009A61K9/2018A61K9/2054A61K9/2059A61K31/167
Inventor 王凤左娟罗磊杨莉梅勇陈小雪龙涛朱锋唐攀陈波
Owner 重庆希尔安药业有限公司
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