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Shuanghuanglian effervescence tablet and preparation method thereof

A technology of Shuanghuanglian and effervescent tablets, which is applied to pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc., can solve the problems of unstable samples and cumbersome preparation methods, and achieve good clarity. , easy to use, ensure the effect of drug efficacy

Inactive Publication Date: 2012-07-04
SICHUAN KELUN PHARMA RES INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such a preparation method is cumbersome, and the prepared samples are still unstable

Method used

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  • Shuanghuanglian effervescence tablet and preparation method thereof
  • Shuanghuanglian effervescence tablet and preparation method thereof
  • Shuanghuanglian effervescence tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] Shuanghuanglian Extract Powder 588g

[0080] Tartaric acid 200g

[0081] Sodium bicarbonate 270g

[0082] Precrossed Starch 120g

[0083] Carboxymethyl Starch Sodium 50g

[0084] Macrogol 6000 40g

[0085] Aspartame 15g

[0086] Silica 6g

[0087] Sweet orange oil essence 5g

[0088] Magnesium Stearate 4g

[0089] Weigh 3750g slices of Scutellaria baicalensis, add 10 times the weight of water and decoct three times, the first time for 2 hours, the second and third times for 1 hour each, combine the decoction, filter, concentrate the filtrate and add 2mol / L hydrochloric acid solution at 80°C to adjust the pH value to 1.0-1.2, keep warm for 1 hour, let stand for 12 hours, filter, add 6-8 times by weight of water to the precipitate, adjust the pH value to 7.0 with 40% sodium hydroxide solution, and then add 7 times by weight of 95% ethanol, Stir to dissolve, filter, adjust the pH value of the filtrate to 2.0 with 2mol / L hydrochloric acid solution, keep it at 60°C f...

Embodiment 2

[0092] Shuanghuanglian Extract Powder 350g

[0093] Citric acid 240g

[0094] Sodium carbonate 400g

[0095] Microcrystalline Cellulose 130g

[0096] Macrogol 4000 25g

[0097] Sucralose 20g

[0098] Strawberry essence 3g

[0099] Silica 8g

[0100] Talc powder 5g

[0101] Weigh 4875g slices of Scutellaria baicalensis, add 10 times the weight of water and decoct three times, the first time for 2 hours, the second and third times for 1 hour each, combine the decoction, filter, concentrate the filtrate and add 2mol / L hydrochloric acid solution at 80°C to adjust pH value to 1.0-1.2, keep warm for 1 hour, stand still for 12 hours, filter, add 6-8 times the weight of water to the precipitate, adjust the pH value to 7.0 with 40% sodium hydroxide solution, and then add 7 times the weight of 95% ethanol , stir to dissolve, filter, adjust the pH value of the filtrate to 2.0 with 2mol / L hydrochloric acid solution, keep it warm at 60°C for 30 minutes, let it stand for 12 hours, fi...

Embodiment 3

[0104] Shuanghuanglian Extract Powder 850

[0105] L-malic acid 160g

[0106] Potassium bicarbonate 140g

[0107] Dextrin 250g

[0108] Macrogol 6000 57g

[0109] Protein sugar 10g

[0110] Sweet orange oil essence 7g

[0111] Silica 4g

[0112] Leucine L 3g

[0113]Weigh 2625g slices of Scutellaria baicalensis, add water 10 times its weight and decoct three times, the first time for 2 hours, the second and third times for 1 hour each, combine the decoction, filter, concentrate the filtrate and add 2mol / L hydrochloric acid solution at 80°C to adjust pH value to 1.0-1.2, keep warm for 1 hour, stand still for 12 hours, filter, add 6-8 times the weight of water to the precipitate, adjust the pH value to 7.0 with 40% sodium hydroxide solution, and then add 6 times the weight of 95% ethanol , stir to dissolve, filter, adjust the pH value of the filtrate to 2.0 with 2mol / L hydrochloric acid solution, keep it warm at 60°C for 30 minutes, let it stand for 12 hours, filter, wash...

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Abstract

The invention discloses a Shuanghuanglian effervescence tablet added with a moisture-proof agent or a drying agent and a preparation method of the Shuanghuanglian effervescence tablet, wherein the raw medicine materials of the effervescence tablet comprise Shuanghuanglian extract powder, an effervescence agent, the moisture-proof agent or the drying agent, a flavoring agent and a lubricating agent. The Shuanghuanglian effervescence tablet has the advantages of reasonable proportion of a main medicine and auxiliary materials, good formation and stability, good clarity after disintegration, convenience in use and favorable mouth feel, and the compliance of the Shuanghuanglian effervescence tablet is increased and medicine effect is guaranteed.

Description

technical field [0001] The invention relates to a Shuanghuanglian effervescent tablet and a preparation method thereof, in particular to a Shuanghuanglian effervescent tablet added with a moisture-proof agent or a desiccant and a preparation method thereof. Background technique [0002] The traditional Chinese medicine Shuanghuanglian preparation is composed of honeysuckle, scutellaria baicalensis and forsythia. It is used for the treatment of fever, cough, sore throat and other symptoms caused by exogenous wind-heat. Its curative effect is very good, is very popular with numerous patients, and the market sales volume is relatively large. According to modern pharmacological research and animal experiments, Shuanghuanglian has antibacterial effects, and has certain inhibitory effects on Staphylococcus aureus, hemolytic streptococcus, pneumococcus, and Shigella. At present, its preparations include Shuanghuanglian oral liquid, Shuanghuanglian tablet, Shuanghuanglian freeze-d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61K9/46A61K47/34A61K47/36A61K47/38A61P11/04A61P11/14A61P29/00
Inventor 张永红杨勇黄燕萍梁隆王利春沈鑫
Owner SICHUAN KELUN PHARMA RES INST CO LTD
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