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Ephedra, semen armeniacae amarae, gypsum and liquorice effervescent granules and preparation method thereof

A technology of Maxing Shigan and effervescent granules, which is applied in the directions of pharmaceutical formulations, medical preparations with inactive ingredients, and medical preparations containing active ingredients, etc. It is difficult to remove the impurities and the dissolution speed is slow, so as to achieve the effect of good clarity, reducing the amount of auxiliary materials and fast effervescence.

Inactive Publication Date: 2014-12-10
SHANDONG MINGFA ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Maxing Shigan granules produced by this single carrier have a slow dissolution rate in water and uneven distribution, and the manufacturing process of Maxing Shigan extract is very rough, and it is difficult to remove non-water-soluble impurities. The impurities contained in it can easily cause the blockage of the drinking fountain. When using it, the farming users have to melt the Maxing Shigan granules with boiling water before putting them into the water tank, and stirring continuously to make them evenly mixed before using them. Inconvenience to the majority of users

Method used

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  • Ephedra, semen armeniacae amarae, gypsum and liquorice effervescent granules and preparation method thereof
  • Ephedra, semen armeniacae amarae, gypsum and liquorice effervescent granules and preparation method thereof

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Embodiment Construction

[0019] The following are specific examples of the present invention, further describing the technical solutions of the present invention, but the protection scope of the present invention is not limited to these examples. All changes or equivalent substitutions that do not depart from the concept of the present invention are included in the protection scope of the present invention.

[0020] Screening of Extraction Technology of Maxing Shigan Extract

[0021] According to the compilation of national standards for veterinary drugs - the second volume of national standards for local standards for veterinary drugs and the experimental results, the active ingredients of ephedra, bitter almonds, gypsum and licorice were extracted by heating, decocting, filtering, and concentrating under reduced pressure to extract. The main factors affecting the extraction efficiency are the amount of water extracted, the extraction time, and the extraction temperature. The extraction rate of the e...

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Abstract

The invention discloses ephedra, semen armeniacae amarae, gypsum and liquorice effervescent granules, belonging to the field of traditional Chinese medicine preparations. The ephedra, semen armeniacae amarae, gypsum and liquorice effervescent granules are prepared from the following raw materials and auxiliary materials by weight: raw materials comprising 300g of ephedra, 90g of semen armeniacae amarae, 1500g of gypsum and 300g of liquorice; and auxiliary materials comprising 100-200g of sodium bicarbonate, 25-50g of clathrate compound, 100-200g of malic acid, 5g of adhesives, 5g of coloring agents and 500-600g of diluents. According to the invention, sodium bicarbonate serves as an alkaline agent, PEG 6000 serves as an inclusion agent, hydroxypropyl methyl cellulose serves as an adhesive, lemon yellow serves as a coloring agent, and malic acid serves as an acid agent. The preparation method comprises the following steps: including alkaline substances, and mixing the alkaline substances with acidic substances, thereby preparing the effervescent granules. The amount of the auxiliary materials can be reduced, and the effervescent granules are simple in preparation process, easy to form, difficult in moisture absorption, high in effervescent speed, good in effervescent effect, high in solubility, high in liquid medicine clarity after effervescence and high in palatability and do not contain coke breeze foreign matters.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a veterinary Maxing Shigan effervescent granule and a preparation method thereof. Background technique [0002] Maxing Shigan granules are granules made by extracting ephedra, bitter almonds, gypsum and licorice into extracts and then mixing them with sucrose in a certain proportion. The function of treating lung-heat cough is mainly used clinically for the respiratory diseases of chickens caused by various reasons. The current veterinary Maxing Shigan granules simply mix the Maxing Shigan extract with a single carrier (mostly anhydrous glucose or sucrose), and extrude through a swinging sieve to form granules. Maxing Shigan granules produced by this single carrier have a slow dissolution rate in water and uneven distribution, and the manufacturing process of Maxing Shigan extract is very rough, and it is difficult to remove non-water-soluble impu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K9/16A61K47/48A61K47/02A61K47/12A61K33/06
Inventor 刘照云关大方刘洪丽
Owner SHANDONG MINGFA ANIMAL MEDICINE
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