Compound uterus-warming and pain-relieving footbath effervescent tablets and preparation method thereof
An effervescent tablet and foot bath technology, which is applied in the directions of non-central analgesics, pharmaceutical formulations, and non-active ingredients medical preparations, etc. Effervescent effect, excellent quality effect
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Embodiment 1
[0040] Example 1 Preparation of Compound Nuan Gong Zhi Pain Foot Bath Effervescent Tablet
[0041] Proportion by weight of raw materials: 30 parts of extract powder; 40 parts of citric acid monohydrate and sodium bicarbonate (molar ratio: 1:3.5); 5 parts of PEG6000; 2 parts of magnesium stearate; 23 parts of lactose;
[0042] Described extract powder is prepared by the following method:
[0043] Preparation method: Weigh motherwort, 10g each of safflower, Mildew Spatholobus, Radix Paeoniae Alba, Artemisia argyi, and Galangal, add 1000mL of 70% ethanol solution, put it in a 2000mL conical flask with a stopper, ultrasonicate for 40min, extract the same amount of 70% ethanol for 2 Second, take the filtrate by suction filtration, reclaim ethanol with a rotary evaporator, put the concentrated extract in an evaporating dish for drying in a water bath, and obtain a dry product; grind the dry product to obtain an extract powder;
[0044] The preparation method of compound Nuangongzhito...
Embodiment 2
[0050] Example 2 Preparation of Compound Nuan Gong Zhi Pain Foot Bath Effervescent Tablets
[0051] Proportion by weight of raw materials: 40 parts of extract powder; 35 parts of citric acid monohydrate and sodium bicarbonate (molar ratio: 1:3.5); 8 parts of PEG6000; 2 parts of magnesium stearate; 15 parts of lactose;
[0052] The preparation method of the extract powder and the preparation method of the compound Nuangongzhitong foot bath effervescent tablet are the same as in Example 1.
[0053] According to the quality standard evaluation in Table 1, the quality scores of the compound Nuangongzhitong foot bath effervescent tablet of this embodiment are as follows: 20 points for anti-adhesiveness, 18 points for tablet properties, 18 points for disintegration, 18 points for effervescent effect, and 20 points for dispersibility , 20 points for floaters; 114 points in total.
Embodiment 3
[0054] Example 3 Preparation of Compound Nuan Gong Zhi Pain Foot Bath Effervescent Tablets
[0055] Proportion by weight of raw materials: 30 parts of extract powder; 45 parts of citric acid monohydrate and sodium bicarbonate (1:3 molar ratio); 5 parts of PEG6000; 1 part of magnesium stearate; 19 parts of lactose;
[0056] The preparation method of the extract powder and the preparation method of the compound Nuangongzhitong foot bath effervescent tablet are the same as in Example 1.
[0057] According to the quality standard evaluation in Table 1, the quality scores of the compound Nuangongzhitong foot bath effervescent tablet of this embodiment are as follows: 18 points for anti-adhesiveness, 18 points for tablet properties, 18 points for disintegration, 18 points for effervescent effect, and 18 points for dispersibility , 20 points for floaters; a total of 110 points.
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