The invention discloses improvement and application of an
oral cavity swab sample preservation solution. The
oral cavity swab sample preservation solution comprises 5-20mM of
Tris, 10-50mM of EDTA, 0.1-0.5M of NaCl, 0.1-.05% of SDS and 0.1-2% of
sodium hydroxymethylglycinate. The
oral cavity swab sample preservation solution also comprises
food preservatives nationally licensed to be used. The preservation temperature of the oral cavity swab sample preservation solution is about 37 DEG C, reagents used in a formula of the preservation solution are cheap and fine, and
DNA detection rate and stability are improved, so that detection cost is reduced; the formula and production steps are simple and convenient, and the used reagents are good in stability, so that long-term storage of a productcan be facilitated; and the preservation solution adopts common preservatives in foods and daily necessities for inhibiting damage of
bacteria on an oral cavity swab sample, the preservatives fully pass through related
verification, use security is high, ingredients of the prepared oral cavity swab sample preservation solution can be compatible with a subsequent
DNA extraction program, and subsequent
DNA extraction is beneficial.