The invention discloses a method and device for medical information sharing privacy protection based on a blockchain technology. According to the method, in aspects of privacy protection based on a blockchain technology, medical data on-chain and off-chain storage and forced privacy protection safety multiparty calculation, illegal medical data obtaining, use and tampering are avoided, and medical information sharing, big data analysis and utilization and patient privacy protection are implemented. The device comprises a data storage module, a service module provided based on the blockchain technology and a call service module provided externally, wherein a three-layer data storage frame is adopted for the data storage module; and the service module provided based on the blockchain technology mainly comprises forced privacy protection safety multiparty calculation. The method and device for medical information sharing privacy protection based on the blockchain technology are mainly applied to the fields of method and device for medical information sharing privacy protection based on a blockchain technology and medical big data analysis and the like, and technical guarantee is also provided for patient privacy protection while medical information sharing is achieved based on the blockchain technology.