The invention belongs to the field of water supply pipe network leakage management systems, in particular to a water supply pipe network leakage management system and an establishment method and system application thereof. In the prior art, through DMA (District Metering Area) zone metering, the independent metering and management of a complex pipe network is realized, and common DMA zone meteringhas the problems of high hardware investment, insufficient hardware laying reasonability, extensive leakage management, shortage of leakage economic evaluation system, imperfect data releasing and sharing mechanism. The water supply pipe network leakage management system comprises a pipe network hydraulic model subsystem, an SCADA (Supervisory Control And Data Acquisition) subsystem, a DMA management subsystem, a leakage management subsystem and a water affairs GIS (Geographic Information System) management subsystem. Through the guidance of basic data, an optimal hydraulic model is established, independent metering zone division is guided through the hydraulic model, pipe network hardware laying is guided, the economic benefit of a laying scheme is accurately evaluated, leakage management is reasonably carried out, and multiple pieces of system data can be shared.