The invention discloses a wallpaper with patterns having a manual three-dimensional effect. The wallpaper comprises a bottom layer, a bottom color layer formed on the bottom layer, and a pattern decorating layer formed on the bottom color layer, wherein the pattern decorating layer is formed by slurry printing, the slurry is prepared by the following substances in parts by weight: 100 parts of pvc (polyvinyl chloride) paste resin, 12 to 180 parts of titanium dioxide, 30 to 180 parts of calcium carbonate, 0.1 to 5 parts of a rheological agent, 20 to 90 parts of a plasticizer, 1 to 5 parts of a stabilizer, and 0.1 to 20 parts of a pigment. According to the invention, by using a general printing manner such as rotary screen printing, an emboss engrave effect can be made, the wallpaper has superstrong stereoscopic sensation, as three steps of coating, printing and embossing in the production technology in the prior art are simplified to be one step, the production technological processes are reduced, the production efficiency is improved, and the manufacturing cost is lowered.