The invention provides a
fenofibrate nano freeze-dried composition and a preparation method thereof. The preparation method comprises: preparing a nano-suspension, and freeze-
drying the suspension. The preparation method provided by the present invention does not need to micronize the
raw material drug in advance, which greatly reduces the
energy consumption required for the experiment; the experimental conditions of the present invention are mild and controllable, the preparation time is short, and the
production cycle is greatly shortened; there is no need to use high-pressure homogenization or Methods such as mechanical
grinding have low requirements on equipment, low
energy consumption, and are not prone to debris
pollution; they are simple to operate, have good reproducibility, low cost, and are easy to realize
industrial scale-up production. In the nanosuspension prepared by the invention, the particle size of the
drug nanoparticles in the suspension is controlled at 150-350nm, the
dissolution and release are fast, the gastrointestinal transmembrane transport capacity of
fenofibrate is greatly improved, and the absorption of
fenofibrate is promoted. .